In Vitro Evidence for Effects of Magnesium Supplementation on Quinolone-treated Horse and Dog Chondrocytes

Egerbacher, Monika; Wolfesberger, Birgitt; Gabler, Cornelia

doi:10.1354/vp.38-2-143

Cited by 28 publications

(36 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This agrees with the study which observed that Ciprofloxacin inhibits tendon cell proliferation and cause cell cycle arrest in rats (Tsai et al, 2008). It was reported that cell proliferation in horse and dog chondrocytes decreased in Ciprofloxacin cultivated groups (Egerbacher et al, 2001).…”

Section: Ajptsupporting

confidence: 92%

Ciprofloxacin Induced Chondrotoxicity and Tendinopathy

Adikwu

Nelson

2012

American Journal of Pharmacology and Toxicology

View full text Add to dashboard Cite

ABSRACTCiprofloxacin is one of the fluoroquinolones with a wide clinical acceptability. Rescently there are increasing reports on Ciprofloxacin induce Chondrotoxicity and Tendinopathy in Animal experiment and clinical experience which is of great clinical concern. A comprehensive survey and review of literaure on reported ciprofloxacin induced Chondrotoxicity and Tendinopathy in Humans and Animals was performed. It was observd that ciprofloxacin is a potential inducer of Chrondrotoxicity and Tendinopathy which could be potentiated by coadministration with corticosteroids.This conditions were reported to be characterised by cartilage lesion, matrix swelling, inhibition of chondrocytes proliferation, secretion of soluble proteoglycan, modification of the metabolism and integrity of extracellular proteins, decrease in epiphyseal growth plate, humerus and femur.The mechanism behind this phenomenon is said to be multifactoral. Ciprofloxacin induced Chrondrotoxicity and Tendinopathy in growing animals is attributed to oxidative stress (lipid peroxidation, Deoxyribonucleic Acid (DNA) oxidative stress). Ciprofloxacin induced cartilage damage may also be attributed to formation of Ciprofloxacin chelates and complexes which possesses the potential to induce a deficiency of functionally available divalent ions resulting in cytoskeletal changes. Animal studies showed that oxidative damage or metabolism of tissues was also found suggesting the involvement of a reactive oxygen species. Administration of magnesium, zinc chloride and vitamin E (α tocopherol) were found to prevent or reverse ciprofloxacin induced Chrondrotoxicity and Tendinopathy. Through excess formation of collagen, increase osteoblastic activity, increase bone growth, inhibition of free oxidation radicals' formation thereby preventing DNA oxidation and oxidative stress. Zinc also directly stimulates DNA synthesis either by enzyme stimulation or altering, the binding of f1 and f3 histones to DNA so as to affect RNA synthesis. Patient medical history should be considered before Ciprofloxacin recommendation. Coadministration with corticosteroid should be done with caution. Further evaluation of antioxidants effect in Ciprofloxacin induce Chonrotoxicity, Tendinopathy in humans could be of clinical importance as observed in Animal studies.

show abstract

Section: Ajptsupporting

confidence: 92%

Ciprofloxacin Induced Chondrotoxicity and Tendinopathy

Adikwu

Nelson

2012

American Journal of Pharmacology and Toxicology

View full text Add to dashboard Cite

show abstract

“…NMDA receptor antagonists have been shown to effectively alleviate pain-related behavior in animal models as well as in clinical situations [17,18]. The safety of IA magnesium sulfate was tested in an unpublished animal study conducted on rats and then in an in vitro animal study conducted by Egerbacher et al [19], and no side effects were detected.…”

Section: Discussionmentioning

confidence: 99%

A comparison of intra-articular magnesium and/or morphine with bupivacaine for postoperative analgesia after arthroscopic knee surgery

Farouk

Aly

2009

J Anesth

View full text Add to dashboard Cite

show abstract

“…These findings have also been confirmed in the chondrocytes of juvenile rats 39 . On the other hand, supplementation with magnesium can reduce the toxic effects of quinolones on chondrocytes in vitro 40 .…”

Section: Cavity Formationmentioning

confidence: 99%

Chondrotoxicity of Quinolone Antimicrobial Agents

Kato

2008

J Toxicol Pathol

View full text Add to dashboard Cite

Quinolone antimicrobial agents induce two types of histological changes in the articular cartilage of synovial joints in immature, but not mature, laboratory animals. The first is cavity formation in the middle zone of the articular cartilage in animals of all species examined so far, and this can be induced by a single or several daily doses. The second is osteochondrotic lesions in the caudal femoral condyles of rats when subchronic or chronic treatment is started at a juvenile age, but there seems to be only one reference for this effect. The development process of cavity formation is as follows. Degeneration and necrosis of chondrocytes are first observed, and the surrounding matrix becomes edematous with demasked collagen fibrils and decreased safranin O stainability. A flat cleft or cavity is then formed in the edematous cartilage, and erosion is sometimes produced by detachment of the cavity outer wall. The potency of quinolones to form chelate complexes with Mg 2+ is discussed as causal for cavity formation. This could lead to Mg 2+ deficiency in the cartilage, resulting in integrin alteration and further radical formation that can finally induce cartilage lesions. On the other hand, an early change of osteochondrosis is a thickened middle zone of the articular cartilage with a thinned deep zone. The thickened cartilage protrudes into the epiphysis and prevents age-dependent thinning of the cartilage. In advanced cases, fissures are formed in the bottom of the thickened cartilage, and extension of the fissures to the cartilage surface induces detachment of the cartilage, subchondral bone necrosis and fibrotic lesions in the marrow space. The lesions are considered to be caused by quinolone-induced inhibition of the differentiation of chondrocytes in the middle zone into those in the deep zone. For chondrotoxicity in juvenile animals, the pediatric use of quinolones is generally contraindicated, but whether or not chondrotoxicity could really occur in pediatric patients is still controversial. (J Toxicol Pathol 2008; 21: 123-131)

show abstract

In Vitro Evidence for Effects of Magnesium Supplementation on Quinolone-treated Horse and Dog Chondrocytes

Cited by 28 publications

References 25 publications

Ciprofloxacin Induced Chondrotoxicity and Tendinopathy

Ciprofloxacin Induced Chondrotoxicity and Tendinopathy

A comparison of intra-articular magnesium and/or morphine with bupivacaine for postoperative analgesia after arthroscopic knee surgery

Chondrotoxicity of Quinolone Antimicrobial Agents

Contact Info

Product

Resources

About