In vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells

Jaworski, Sławomir; Sawosz, Ewa; Grodzik, Marta; Winnicka, A.; Prasek, Marta; Wierzbicki, Mateusz; Chwalibog, A.

doi:10.2147/ijn.s39456

Cited by 64 publications

(27 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To some extent, the chemical properties of graphene are similar to those of graphite, owing to the fact that, in both cases, C-atoms are sp 2 hybridized. Jaworski et al [ 39 ] published their work on the influence of graphene platelets on the morphology, mortality, viability, membrane integrity and type of cell death. Our studies on graphite partially confirmed their results in the case of the MTT test and morphology observations of glioblastoma cells treated with graphene.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Cytotoxicity of Carbon-Based Nanoparticles, Diamond and Graphite, in Human Glioblastoma and Hepatoma Cell Lines

et al. 2015

Self Cite

View full text Add to dashboard Cite

Nanoparticles have attracted a great deal of attention as carriers for drug delivery to cancer cells. However, reports on their potential cytotoxicity raise questions of their safety and this matter needs attentive consideration. In this paper, for the first time, the cytotoxic effects of two carbon based nanoparticles, diamond and graphite, on glioblastoma and hepatoma cells were compared. First, we confirmed previous results that diamond nanoparticles are practically nontoxic. Second, graphite nanoparticles exhibited a negative impact on glioblastoma, but not on hepatoma cells. The studied carbon nanoparticles could be a potentially useful tool for therapeutics delivery to the brain tissue with minimal side effects on the hepatocytes. Furthermore, we showed the influence of the nanoparticles on the stable, fluorescently labeled tumor cell lines and concluded that the labeled cells are suitable for drug cytotoxicity tests.

show abstract

Section: Discussionmentioning

confidence: 99%

Analysis of the Cytotoxicity of Carbon-Based Nanoparticles, Diamond and Graphite, in Human Glioblastoma and Hepatoma Cell Lines

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…al. have reported the interactions of graphene platelets with human glioblastoma U87 and U118 cells [68]. After 24 hours of incubation with 100 µg/ml graphene, 42% and 52% cell mortality was observed for U87 and U118 cells, respectively.…”

Section: In Vitro Toxicitymentioning

confidence: 99%

Toxicology of graphene-based nanomaterials

Lalwani

D’Agati

Khan

et al. 2016

Advanced Drug Delivery Reviews

248

151

View full text Add to dashboard Cite

Graphene based nanomaterials possess remarkable physiochemical properties suitable for diverse applications in electronics, telecommunications, energy and healthcare. The human and environmental exposure to graphene-based nanomaterials is increasing due to advancements in the synthesis, characterization and large-scale production of graphene and the subsequent development of graphene based biomedical and consumer products. A large number of in vitro and in vivo toxicological studies have evaluated the interactions of graphene-based nanomaterials with various living systems such as microbes, mammalian cells, and animal models. A significant number of studies have examined the short- and long-term in vivo toxicity and biodistribution of graphene synthesized by variety of methods and starting materials. A key focus of these examinations is to properly associate the biological responses with chemical and morphological properties of graphene. Several studies also report the environmental and genotoxicity response of pristine and functionalized graphene. This review summarizes these in vitro and in vivo studies and critically examines the methodologies used to perform these evaluations. Our overarching goal is to provide a comprehensive overview of the complex interplay of biological responses of graphene as a function of their physio-chemical properties.

show abstract

“…Other cancer types such as Burkitt's lymphoma 33 , colon cancer 34 , 70 , 71 , 78 , 91 , prostate cancer 35 , 64 , 87 , lung cancer 43 , 56 , 63 , 76 , 80 , 87 , skin cancer 57 , 60 , brain cancer 20 , 38 , 46 - 48 , 61 , 62 , glioma 90 and glioblastoma 72 were studied under different drug treatment conjugated with graphene or graphene oxide.…”

Section: Drug and Gene Deliverymentioning

confidence: 99%

“…On the other hand, specific toxic effects of graphene on cancer cells could represent a positive point. Indeed, many reports have shown that this function of graphene could be useful in possible future therapeutic applications 20 , 21 , for example as an inhibitor of cancer cell metastasis 22 . Furthermore, different anticancer biomolecules such as siRNA, DNA and other drugs can be loaded onto the graphene surface for gene silencing and transfection, drug delivery and many other cancer therapy applications 23 .…”

Section: Introductionmentioning

confidence: 99%

Graphene as Cancer Theranostic Tool: Progress and Future Challenges

Orecchioni¹,

Cabizza²,

Bianco³

et al. 2015

Theranostics

241

138

View full text Add to dashboard Cite

Nowadays cancer remains one of the main causes of death in the world. Current diagnostic techniques need to be improved to provide earlier diagnosis and treatment. Traditional therapy approaches to cancer are limited by lack of specificity and systemic toxicity. In this scenario nanomaterials could be good allies to give more specific cancer treatment effectively reducing undesired side effects and giving at the same time accurate diagnosis and successful therapy. In this context, thanks to its unique physical and chemical properties, graphene, graphene oxide (GO) and reduced graphene (rGO) have recently attracted tremendous interest in biomedicine including cancer therapy.Herein we analyzed all studies presented in literature related to cancer fight using graphene and graphene-based conjugates. In this context, we aimed at the full picture of the state of the art providing new inputs for future strategies in the cancer theranostic by using of graphene.We found an impressive increasing interest in the material for cancer therapy and/or diagnosis. The majority of the works (73%) have been carried out on drug and gene delivery applications, following by photothermal therapy (32%), imaging (31%) and photodynamic therapy (10%). A 27% of the studies focused on theranostic applications. Part of the works here discussed contribute to the growth of the theranostic field covering the use of imaging (i.e. ultrasonography, positron electron tomography, and fluorescent imaging) combined to one or more therapeutic modalities. We found that the use of graphene in cancer theranostics is still in an early but rapidly growing stage of investigation. Any technology based on nanomaterials can significantly enhance their possibility to became the real revolution in medicine if combines diagnosis and therapy at the same time. We performed a comprehensive summary of the latest progress of graphene cancer fight and highlighted the future challenges and the innovative possible theranostic applications.

show abstract

In vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells

Cited by 64 publications

References 25 publications

Analysis of the Cytotoxicity of Carbon-Based Nanoparticles, Diamond and Graphite, in Human Glioblastoma and Hepatoma Cell Lines

Analysis of the Cytotoxicity of Carbon-Based Nanoparticles, Diamond and Graphite, in Human Glioblastoma and Hepatoma Cell Lines

Toxicology of graphene-based nanomaterials

Graphene as Cancer Theranostic Tool: Progress and Future Challenges

Contact Info

Product

Resources

About