In Vitro Evaluation of the Dermatocosmetic Emulsions Based on Lady's Bedstraw (Galium Verum) Alchoolic Extracts

Turcov, Delia; Peptu, Anisoara Catalina; Barna, Ana Simona; Zbranca, Anca; Sutcu, Daniela

doi:10.1109/ehb55594.2022.9991353

Cited by 3 publications

(4 citation statements)

References 13 publications

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“…The stability of the prepared emulsions was assessed throughout time as well as potential microbial contamination during storage or usage of dermato-cosmetic preparation [ 37 , 39 , 40 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 ].…”

Section: Resultsmentioning

confidence: 99%

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Preliminary Approaches to Cosmeceuticals Emulsions Based on N-ProlylPalmitoyl Tripeptide-56 Acetat-Bakuchiol Complex Intended to Combat Skin Oxidative Stress

Barna

Maxim

Trifan

et al. 2023

IJMS

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This study focuses on the development of a performant formulation for O/W dermato-cosmetic emulsions, which can be incorporated into novel dermato-cosmetic products or used as such. The O/W dermato-cosmetic emulsions contain an active complex based on a plant-derived monoterpene phenol, bakuchiol (BAK) and a signaling peptide named n-prolyl palmitoyl tripeptide-56 acetate (TPA). As a dispersed phase, we used a mix of vegetable oils, and as a continuous phase, Rosa damascena hydrosol was employed. Three emulsions containing different concentrations of the active complex were formulated (0.5% BAK + 0.5% TPA = E.1.1., 1% BAK + 1%TPA = E.1.2., 1% BAK + 2% TPA = E.1.3.). Stability testing was performed through sensory analysis, stability after centrifugation, conductivity and optical microscopy. A preliminary in vitro study regarding the diffusion ability of antioxidants through chicken skin was also undertaken. DPPH and ABTS assays were used to highlight the optimal concentration and combination in the formulation in terms of antioxidant properties and safety level of the active complex (BAK/TPA). Our results showed that the active complex used for preparing emulsions with BAK and TPA showed good antioxidant activity and is suitable for obtaining topical products with potential antiaging effects.

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Section: Resultsmentioning

confidence: 99%

“…The working protocol was adapted according to our previous study [ 50 ] and information from the literature [ 51 , 52 ]. A precise amount of emulsion E.1.3.…”

Section: Methodsmentioning

confidence: 99%

Preliminary Approaches to Cosmeceuticals Emulsions Based on N-ProlylPalmitoyl Tripeptide-56 Acetat-Bakuchiol Complex Intended to Combat Skin Oxidative Stress

Barna

Maxim

Trifan

et al. 2023

IJMS

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“…There are a number of clinical studies investigating the benefits of antioxidants, particularly for photoaging. The study protocols involve healthy subjects (men and women [43] or women only [44,45]), and the effect of long-term treatment with antioxidants is evaluated by studying their protective effects and the improvement in some of the oxidative stressinduced manifestations highlighted. Typically, subjects of different ages with fine or deep wrinkles, mild or moderate hyperpigmentation, dehydration and loss of skin luster, low tone and elasticity are included in such studies.…”

Section: IImentioning

confidence: 99%

“…In addition, new effective solutions to combat and mitigate the harmful effects of oxidative stress at the cellular and tissue levels are constantly being sought and studied, using effective, safe and natural methods. Dermatology has the advantage of gently incorporating therapeutic ingredients into gestures that are already present in patients' habits [50]. In this context, a number of studies have shown the importance of associating antioxidants to increase the protective activities in the cells and tissues of the body, with strong evidence for the prevention and alleviation of major diseases, whether systemic or cutaneous (Table 3).…”

Section: Bioactive Compounds As Antioxidant Ingredients In Dermatocos...mentioning

confidence: 99%

Bioactive Compounds for Combating Oxidative Stress in Dermatology

Turcov,

Zbranca-Toporas,

Suteu

2023

IJMS

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There are extensive studies that confirm the harmful and strong influence of oxidative stress on the skin. The body’s response to oxidative stress can vary depending on the type of reactive oxygen species (ROS) or reactive nitrogen species (RNS) and their metabolites, the duration of exposure to oxidative stress and the antioxidant capacity at each tissue level. Numerous skin diseases and pathologies are associated with the excessive production and accumulation of free radicals. title altered Both categories have advantages and disadvantages in terms of skin structures, tolerability, therapeutic performance, ease of application or formulation and economic efficiency. The effect of long-term treatment with antioxidants is evaluated through studies investigating their protective effect and the improvement of some phenomena caused by oxidative stress. This article summarizes the available information on the presence of compounds used in dermatology to combat oxidative stress in the skin. It aims to provide an overview of all the considerations for choosing an antioxidant agent, the topics for further research and the answers sought in order to optimize therapeutic performance.

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Preliminary Studies about Valorization of Acmella oleracea Bioactive Content in Modern Dermato-Cosmetic Applications to Combat Skin Oxidative Stress

Turcov,

Trifan,

Puitel

et al. 2024

IJMS

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The development of products with skin-protective effects has been driven by the increasing incidence of skin diseases that are exacerbated by increasing pollution, urbanization, poor living, working, fatigue, dietary habits, and general treatment. The ability of antioxidants to protect the skin from oxidative stress and its effects makes them one of the most important ingredients in today’s cosmetics. This article aims first to characterize the plant extracts obtained from Acmella oleracea (A. oleracea) and then to evaluate the preliminary criteria for a new marketed product: the stability, antioxidant activity, and in vitro behavior of certain serums based on A. oleracea plant extract and hyaluronic acid. The extracts were obtained by liquid–solid extraction methods (maceration (M), ultrasound-assisted extraction (UEA), and a combined method between these two (UEA + M) using an aqueous solution of ethyl alcohol as the extraction solvent. The determination of the amounts of compounds with antioxidant activity highlighted the fact that the extract obtained from the whole plant of A. oleracea using maceration in conditions of S/L = 1:30, 20 days, and an extraction solvent percentage of 50% led to obtaining the highest amount of polyphenols (30.42 μg GAE/g), while using the combined UAE + M method under conditions of S/L = 1:30, 6 min + 20 days, and 50% extraction solvent led to obtaining the highest amount of flavonoids (32.88 mg QE/g). The tests performed on dermato-cosmetic serums based on the plant extract and multimolecular hyaluronic acid (HA) (1 HA with HMW—1.0 mDa–1.6 mDa; HA with LMW—10 kDa–200 kDa; and HA OLIGO, MW < 10 kDa) led to the conclusion that they exhibit structural stability, good shear behavior revealing a satisfactory texture, and high physical stability during storage. These results encourage the transition to in-depth testing, both microbiological and dermatological, as a final step in the consideration of a new commercial product.

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In Vitro Evaluation of the Dermatocosmetic Emulsions Based on Lady's Bedstraw (Galium Verum) Alchoolic Extracts

Cited by 3 publications

References 13 publications

Preliminary Approaches to Cosmeceuticals Emulsions Based on N-ProlylPalmitoyl Tripeptide-56 Acetat-Bakuchiol Complex Intended to Combat Skin Oxidative Stress

Preliminary Approaches to Cosmeceuticals Emulsions Based on N-ProlylPalmitoyl Tripeptide-56 Acetat-Bakuchiol Complex Intended to Combat Skin Oxidative Stress

Bioactive Compounds for Combating Oxidative Stress in Dermatology

Preliminary Studies about Valorization of Acmella oleracea Bioactive Content in Modern Dermato-Cosmetic Applications to Combat Skin Oxidative Stress

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