In Vitro Evaluation of Teratogenic Effects by Time-Varying MR Gradient Fields on Fetal Human Fibroblasts

Rodegerdts, Enno; Grönewäller, E; Kehlbach, Rainer; Roth, Petra; Wiskirchen, Jakub; Gebert, Regina; Claussen, Claus D.; Duda, Stephan H.

doi:10.1002/1522-2586(200007)12:1<150::aid-jmri16>3.0.co;2-9

Cited by 28 publications

(10 citation statements)

References 37 publications

(17 reference statements)

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“…Other studies [49,50] report no significant genotoxic effects as measured by sister chromatid exchange frequencies in human lymphocytes exposed to time varying fields of up to 220 μT, suggesting they are unlikely to act as carcinogens. Other studies report increased DNA synthesis in human fibroblast with exposure at 4 to 15 kHz [51], while fetal cell growth and cell cycle distribution of human lung fibroblasts exposed to gradient of 10mT/m are not affected [52]. These results provided no support for a teratogenic effect of this type of MF.…”

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 79%

Biological Effects and Safety in Magnetic Resonance Imaging: A Review

Hartwig

Giovannetti

Vanello

et al. 2009

IJERPH

198

124

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Since the introduction of Magnetic Resonance Imaging (MRI) as a diagnostic technique, the number of people exposed to electromagnetic fields (EMF) has increased dramatically. In this review, based on the results of a pioneer study showing in vitro and in vivo genotoxic effects of MRI scans, we report an updated survey about the effects of non-ionizing EMF employed in MRI, relevant for patients’ and workers’ safety. While the whole data does not confirm a risk hypothesis, it suggests a need for further studies and prudent use in order to avoid unnecessary examinations, according to the precautionary principle.

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Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 79%

Biological Effects and Safety in Magnetic Resonance Imaging: A Review

Hartwig

Giovannetti

Vanello

et al. 2009

IJERPH

198

124

View full text Add to dashboard Cite

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“…To our knowledge at least 19 publications have reported about this topic since 1995. Ten of them showed a positive influence on cell cycle progression [Liboff et al, 1984;Levin and Ernst, 1995;Zhang et al, 1995;Clejan et al, 1996;Eremenko et al, 1997;Schimmelpfeng and Dertinger, 1997;Rapley et al, 1998;Cridland et al, 1999;Buemi et al, 2001;Markkanen et al, 2001], whereas nine were negative [Raylmann et al, 1996;Reipert et al, 1996;Nafziger et al, 1997;Sakurai et al, 1999;Wiskirchen et al, 1999Wiskirchen et al, , 2000Loberg et al, 2000;Rodegerts et al, 2000;Mangiacasale et al, 2001]. The difference (negative vs. positive) is most probably due to different exposure conditions and different experimental controls.…”

Section: Introductionmentioning

confidence: 99%

No influence of magnetic fields on cell cycle progression using conditions relevant for patients during MRI

Schiffer

Schreiber

Graf

et al. 2003

Bioelectromagnetics

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The purpose of this study was to examine whether exposure to magnetic fields (MFs) relevant for magnetic resonance imaging (MRI) in clinical routine influences cell cycle progression in two tumor cell lines in vitro. HL60 and EA2 cells were exposed to four types of MFs: (i) static MF of 1.5 and 7.05 T, (ii) extremely low frequency magnetic gradient fields (ELFMGFs) with +/- 10 mT/m and 100 Hz, as well as +/- 100 mT/m and 100 Hz, (iii) pulsed high frequency MF in the radiofrequency (RF) range (63.6 MHz, 5.8 microT), and (iv) a combination of (i-iii). Exposure periods ranged from 1 to 24 h. Cell cycle distribution (G(0)/G(1), S, and G(2)/M phases) was analyzed by flow cytometry. Cell cycle analysis did not reveal differences between the exposed and the control cells. As expected, positive controls with irradiated (8 Gy) HL60 and EA2 cells showed a strong G(2)/M arrest. Using conditions that are relevant for patients during MRI, no influence of MFs on cell cycle progression was observed in these cell lines. Care was taken to control secondary parameters of influence, such as vibration by the MR scanner or temperature to avoid false positive results.

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“…(182) A study performed by Rodegerdts et al, showed that there were no effects on cell proliferation when fetal human fibroblasts were exposed to varying gradient fields, even in cases of prolonged exposure of up to 24 hours, further suggesting a lack of teratogenicity related to magnetic field exposure and gradient field switching. (284) There is also little support in the current literature to suggest that peripheral nerve stimulation poses an increased risk to the fetus when transitioning from 1.5T to 3T. The effects of peripheral nerve stimulation, independent of the magnetic field strength, have a smaller effect on the region of the image towards the geometric centers of the gradient fields used, which is where the fetus is located.…”

Section: Fetal Imagingmentioning

confidence: 97%

MRI evaluation and safety in the developing brain

Tocchio

Kline‐Fath

Kanal

et al. 2015

Seminars in Perinatology

113

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Magnetic resonance imaging (MRI) evaluation of the developing brain has dramatically increased over the last decade. Faster acquisitions and the development of advanced MRI sequences such as magnetic resonance spectroscopy (MRS), diffusion tensor imaging (DTI), perfusion imaging, functional MR imaging (fMRI), and susceptibility weighted imaging (SWI), as well as the use of higher magnetic field strengths has made MRI an invaluable tool for detailed evaluation of the developing brain. This article will provide an overview of the use and challenges associated with 1.5T and 3T static magnetic fields for evaluation of the developing brain. This review will also summarize the advantages, clinical challenges and safety concerns specifically related to MRI in the fetus and newborn, including the implications of increased magnetic field strength, logistics related to transporting and monitoring of neonates during scanning, sedation considerations and a discussion of current technologies such as MRI-conditional neonatal incubators and dedicated small-foot print neonatal intensive care unit (NICU) scanners.

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In Vitro Evaluation of Teratogenic Effects by Time-Varying MR Gradient Fields on Fetal Human Fibroblasts

Cited by 28 publications

References 37 publications

Biological Effects and Safety in Magnetic Resonance Imaging: A Review

Biological Effects and Safety in Magnetic Resonance Imaging: A Review

No influence of magnetic fields on cell cycle progression using conditions relevant for patients during MRI

MRI evaluation and safety in the developing brain

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