In vitro evaluation of poly(caporlactone) grafted dextran (PGD) nanoparticles with cancer cell

Prabu, P.; Chaudhari, Atul A.; Aryal, Santosh; Dharmaraj, N.; Park, S. Y.; Kim, W. D.; Kim, H. Y.

doi:10.1007/s10856-007-3307-z

Cited by 12 publications

(9 citation statements)

References 24 publications

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“…Such surfactants are biodegradable, biocompatible, and nonimmunogenic. 139 Examples include, but not limited to, are poly(caprolactone) grafted silylated dextran, 139 141 studied niosomal formulations of timolol maleate (TM) with surface coating of TM niosomes with chitosan and carbopol. The parameters under consideration were in vitro release and IOP lowering effect.…”

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confidence: 99%

“…All the formulations were well tolerated suggesting that gentamicin niosomes may be used as a safe topical ocular drug delivery system. To treat glaucoma and to determine the IOP lowering effect, Prabu et al 139 studied feasibility of liposome and niosome as a vesicular carrier system for brimonidine tartarate and compared their efficacy with the marketed solution. Brimonidine tartarate carrier systems were in the size range of 210-245 nm, with a high drug loading of 42 wt%.…”

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confidence: 99%

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Novel Strategies for Anterior Segment Ocular Drug Delivery

Cholkar

Patel

Vadlapudi

et al. 2013

Journal of Ocular Pharmacology and Therapeutics

149

107

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Research advancements in pharmaceutical sciences have led to the development of new strategies in drug delivery to anterior segment. Designing a new delivery system that can efficiently target the diseased anterior ocular tissue, generate high drug levels, and maintain prolonged and effective concentrations with no or minimal side effects is the major focus of current research. Drug delivery by traditional method of administration via topical dosing is impeded by ocular static and dynamic barriers. Various products have been introduced into the market that prolong drug retention in the precorneal pocket and to improve bioavailability. However, there is a need of a delivery system that can provide controlled release to treat chronic ocular diseases with a reduced dosing frequency without causing any visual disturbances. This review provides an overview of anterior ocular barriers along with strategies to overcome these ocular barriers and deliver therapeutic agents to the affected anterior ocular tissue with a special emphasis on nanotechnology-based drug delivery approaches.

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confidence: 99%

mentioning

confidence: 99%

Novel Strategies for Anterior Segment Ocular Drug Delivery

Cholkar

Patel

Vadlapudi

et al. 2013

Journal of Ocular Pharmacology and Therapeutics

149

107

View full text Add to dashboard Cite

show abstract

“…An ocular irritancy test of niosomes demonstrated no sign of redness, inflammation, or increased tear production, suggesting that niosomes can be used as an enhanced and safe topical ocular drug delivery system. Prabu et al studied the feasibility of using both liposome and niosome systems as a drug delivery system for brimonidine tartrate, to improve its IOP lowering activity for the treatment of glaucoma 80. The vesicle formulations were in the size range of 210–245 nm, with a drug payload up to 42 wt%.…”

Section: Recent Developments Of Nanomaterials In Ophthalmic Formulmentioning

confidence: 99%

Nanomaterials for Ocular Drug Delivery

Liu

Jones

2012

Macromolecular Bioscience

165

125

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Efficient drug delivery to the eye remains a challenging task for pharmaceutical scientists. Due to the various anatomical barriers and the clearance mechanisms prevailing in the eye, conventional drug delivery systems, such as eye drop solutions, suffer from low bioavailability. More invasive methods, such as intravitreal injections and implants, cause adverse effects in the eye. Recently, an increasing number of scientists have turned to nanomaterial-based drug delivery systems to address the challenges faced by conventional methods. This paper highlights recent applications of various nanomaterials, such as polymeric micelles, hydrogels, liposomes, niosomes, dendrimers, and cyclodextrins as ocular drug delivery systems to enhance the bioavailability of ocular therapeutic agents.

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“…The main advantage of SEM is not only to determine the sizes of individual particles but also to elucidatethe surface morphology of the particles. The atomic force microscope (AFM) has been extensively used for nanoparticle characterization [28][29][30]. AFM has several advantages over SEM/TEM for characterizing nanoparticles.…”

Section: Particle Sizementioning

confidence: 99%

Current Analytical Methods Used in the In Vitro Evaluation of Nano-Drug Delivery Systems

Nagvekar¹,

Trickler²,

Dash³

2009

CPA

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Nano-Drug Delivery Systems have emerged as an effective means of targeting therapeutic agents such as drugs, peptides and proteins to various target sites. The unique advantages and potential targeting capability of this approach have claimed it as the drug delivery system of the future. Various analytical methodologies have been used for the evaluation of this delivery system both in vitro and in vivo. This review will attempt to describe the various in vitro methods used for this purpose, their importance and limitations. The in vitro methods include particle sizing, zeta potential, microscopy, Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry, X-ray diffraction, in vitro release characteristics, determination of drug loading, encapsulation efficiency and loading efficiency. In vitro cell culture has also been utilized in cellular uptake, transmission electron microscopy, MTT assays, flow cytometry, and cellular transport studies. In summary, this in-depth review will provide the basic understanding, as well as the pros and cons of commonly used analytical methods currently utilized to evaluate this emerging drug delivery system.

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In vitro evaluation of poly(caporlactone) grafted dextran (PGD) nanoparticles with cancer cell

Cited by 12 publications

References 24 publications

Novel Strategies for Anterior Segment Ocular Drug Delivery

Novel Strategies for Anterior Segment Ocular Drug Delivery

Nanomaterials for Ocular Drug Delivery

Current Analytical Methods Used in the In Vitro Evaluation of Nano-Drug Delivery Systems

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