Nanomedicine in Cancer 2017
DOI: 10.1201/b22358-25
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In vitro Evaluation of Novel Polymer-Coated Magnetic Nanoparticles for Controlled Drug Delivery

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Cited by 3 publications
(4 citation statements)
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“…The MDNPs were found to be cytocompatible with low toxicity in vitro using cell cultures. Good MDNP cytocompatibility with HDFs and AT1 cells observed in our studies concurs with results from previous studies with the copolymer 44 , 45 and nanoparticles prepared using the monomers (either PNIPAAm or carboxymethyl chitosan) 46 , 47 . The dose-dependent uptake seen by us is also in line with the findings of Sanoj Rejinold et al .…”
Section: Discussionsupporting
confidence: 92%
“…The MDNPs were found to be cytocompatible with low toxicity in vitro using cell cultures. Good MDNP cytocompatibility with HDFs and AT1 cells observed in our studies concurs with results from previous studies with the copolymer 44 , 45 and nanoparticles prepared using the monomers (either PNIPAAm or carboxymethyl chitosan) 46 , 47 . The dose-dependent uptake seen by us is also in line with the findings of Sanoj Rejinold et al .…”
Section: Discussionsupporting
confidence: 92%
“…The development of TFP-MNPs will not only overcome the drawbacks of the long-term toxicity of quantum dots and poor photostability of organic dyes, but also allow simultaneous diagnosis and treatment of cancers in a single setting. In the future, these nanoparticles with the use of alternating magnetic fields, could be used for producing heat for hyperthermia therapy and temperature-controlled drug release, enabling combinational treatment options [23,24]. Therefore, we think that TFP-MNPs can serve as an effective platform for future development of theranostic nanoparticles.…”
Section: Discussionmentioning
confidence: 99%
“…The iron content in the nanoparticles was evaluated using iron assays as described previously [24]. Briefly, 100 µl of the nanoparticle solution was incubated with 50% (v/v) hydrochloric acid at 37°C overnight.…”
Section: Magnetic Characterizationmentioning
confidence: 99%
“…Πολλές επιστηµονικές οµάδες στον κόσµο συνδυάζουν τις ιδιότητες των οξειδίων του σιδήρου (αιµατίτη, µαγκεµίτη και µαγνητίτη τα οποία είναι βιοσυµβατά) και µήτρες πολυµερών όπως το πολυ(γλυκολικό οξύ), η πολυ(αιθυλενογλυκόλη), η πολυ(καπρολακτόνη),η χιτοζάνη και άλλες ώστε να πετύχουν το βέλτιστο αποτέλεσµα χωρίς να βλάπτονται τα υπόλοιπα όργανα ή ιστοί του σώµατος (κυρίως στην χηµειοθεραπεία). Οι ιδιότητες του καθενός συνθέτου υλικού πολυµερούς/οξειδίου του σιδήρου εξαρτώνται από την αντίδραση του συνθέτου στο επιβαλλόµενο µαγνητικό πεδίο και η καθοδήγησή του στο όργανο ή ιστό όπου υπάρχει η βλάβη καθώς και ο τρόπος της αποδέσµευσης του φαρµάκου [36,37,38].…”
Section: μεταφορά και αποδέσµευση φαρµακευτικών ουσιώνunclassified