In Vitro Evaluation of Griseofulvin, Ketoconazole, and Itraconazole Against Various Dermatophytes in Singapore

Goh, C. J.; Tay, Yong Kwang; Ali, Kamarudin Bin; Koh, Mong Teck; Seow, Chew Swee

doi:10.1111/j.1365-4362.1994.tb01523.x

Cited by 33 publications

(24 citation statements)

References 8 publications

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“…Artis et al [3]have shown by testing griseofulvin on dermatophytes that a MIC of 3 µg/ml or greater was indicative of a lack of sensitivity to griseofulvin in vitro. Similar observations were made in 4 patients with dermatophytosis which did not respond to griseofulvin and whose isolated fungi had a MIC of 64 µg/ml or even more [16]. In the case of itraconazole treatments, only one study has shown that, for most dermatophytes, the sensitivity in vitro could be correlated to those in vivo [21].…”

Section: Discussionsupporting

confidence: 56%

“…The MIC obtained with itraconazole (40–80 µg/ml) was clearly higher than that reported by Clayton (0.03–0.50 µg/ml) [17]and Goh and Tay (<0.25 µg/ml for 81% and >64 µg/ml for 11% of the species tested) [16]. It is well known that various factors, like the type and compound of medium, the inoculum concentration, the pH and the duration of incubation, influence the results of the in vitro susceptibility tests.…”

Section: Discussionmentioning

confidence: 55%

“…The inocula were inversely deposited so that the fungi were directly in contact with the media. Dermatophytes not directly in contact with the antifungal drug are not subject to inhibition, because of the tendency of some dermatophytes to continue aerial extension with only a few hyphae [16]. …”

Section: Methodsmentioning

confidence: 99%

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Tinea capitis Dermatophytes: Susceptibility to Antifungal Drugs Tested in vitro and in vivo

et al. 1998

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Background: Tinea capitis is a worldwide-spread infection of the scalp caused by dermatophytes and is predominantly seen in children. The clinical manifestations range from mild scaling lesions to widespread alopecia or highly inflammatory suppurating lesions. Terbinafine and itraconazole seem to be promising therapies with shorter treatment durations than griseofulvin. Objective: The objective of the present study was to test the sensitivity of different species of dermatophytes towards terbinafine and itraconazole, and to compare the results with a retrospective study on 35 immunocompetent patients with tinea capitis who were treated with terbinafine (Lamisil^®). Methods: Minimal inhibitory concentrations (MIC) were measured with an agar dilution method. Results: Each tested species of dermatophyte was sensitive to terbinafine and itraconazole at different concentration ranges. The MIC for terbinafine ranged from 0.005 to 0.5 μg/ml and for itraconazole from 40 to 80 μg/ml. Microsporum canis was the dermatophyte least sensitive to terbinafine. Our retrospective study showed that the cure rate was excellent for Trichophyton violaceum and T. soudanense, variable for T. mentagrophytes and poor for M. canis and M. langeronii. Conclusions: (i) Regarding the results of susceptibility tests obtained with species involved in tinea capitis, clinical efficacy is not related to MIC measured in vitro; (ii) identification of the isolated dermatophyte from tinea capitis seems to be important for choosing the appropriate treatment.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 55%

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Tinea capitis Dermatophytes: Susceptibility to Antifungal Drugs Tested in vitro and in vivo

et al. 1998

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“…[18][19][20][21][22][23] This heightened susceptibility is refl ected by an MIC that is an order of magnitude lower than IC 95 for sterol biosynthesis. 6 Given that dermatophyte growth can be fully inhibited despite only partial inhibition of sterol synthesis, the activity of terbinafi ne is likely accounted for by other processes including the intracellular accumulation of squalene.…”

Section: Clinical Mycologymentioning

confidence: 99%

Update on terbinafine with a focus on dermatophytoses

Newland¹,

Abdel‐Rahman

2009

CCID

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Since terbinafi ne was introduced on the world market 17 years ago, it has become the leading antifungal for the treatment of superfi cial fungal infections, aided by unique pharmacologic and microbiologic profi les. This article reviews mode of action, antimycotic spectrum and disposition profi le of terbinafi ne. It examines the data, accumulated over 15 years, on the comparative effi cacy of terbinafi ne (vs griseofulvin, itraconazole, fl uconazole) in the management of the infections for which it is primarily indicated (eg, dermatophytoses) and provides a brief discussion on its use for the treatment of non-dermatophyte infections. Finally, the available data on the newest topical and systemic formulations are introduced.

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“…in tinea capitis or tinea unguium [1]. While the number of available antimycotics has increased considerably over the last years, more and more reports have been published stating recalcitrance to therapy or even resistance of a dermatophyte against the antimicrobial agents used [2][3][4]. In order to determine the capability of antimycotics to eradicate dermatophytes, the implementation of in vitro susceptibility testing may prove helpful, as is now established with Candida species.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Susceptibility Testing of Dermatophytes – Comparison of the Agar Macrodilution and Broth Microdilution Tests

et al. 1997

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Fifty dermatophyte strains, recently obtained from clinical material, belonging to 4 different species were examined for their susceptibility to 5 systemic or topical antimycotic agents using both an agar macrodilution and a broth microdilution test. Antimycotics compared were griseofulvin, itraconazole, sertaconazole, terbinafine and ciclopiroxolamine. A comparison of the minimum inhibitory concentrations (MIC) clearly showed differences between the two test methods applied. For all 5 antimycotics, MIC data were three- to seventyfold lower in the microdilution test system. These differences, depending on the test method, have to be taken into account when comparing MIC data in the literature or when relating the in vitro data to the tissue concentrations determined in vivo.

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In Vitro Evaluation of Griseofulvin, Ketoconazole, and Itraconazole Against Various Dermatophytes in Singapore

Abstract: The in vitro antifungal activity of griseofulvin, ketoconazole, and itraconazole are similar against dermatophytes in Singapore. Griseofulvin may be given as the first-line drug for treating such infections in Singapore.

Cited by 33 publications

References 8 publications

Tinea capitis Dermatophytes: Susceptibility to Antifungal Drugs Tested in vitro and in vivo

Tinea capitis Dermatophytes: Susceptibility to Antifungal Drugs Tested in vitro and in vivo

Update on terbinafine with a focus on dermatophytoses

Antimicrobial Susceptibility Testing of Dermatophytes – Comparison of the Agar Macrodilution and Broth Microdilution Tests

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