In Vitro evaluation of domperidone mouth dissolving tablets

Patra, Sradhanjali; Sahoo, Ranjan Kumar; Panda, Radharani; Himasankar, K; Barik, B. B.

doi:10.4103/0250-474x.84607

Cited by 7 publications

(4 citation statements)

References 5 publications

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“…In 5 min, the drug release increased to 94.27% (F6). According to the findings, MDTs with 40 mg of Crospovidone and 10 mg of SSG are the formulation that maximizes Tribulus terrestris release [34].…”

Section: In Vitro Drug Release Study Of Formulation (F1-f9)mentioning

confidence: 99%

Design, Development and Fabrication of Mouth-Dissolving Tablets Containing Extract of Tribulus Terrestris for the Treatment of Hypertension

et al. 2023

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Objective: The present work is aim to design, development and fabrication of mouth dissolving tablets containing extract of Tribulus terrestris for the treatment of hypertension. Methods: The extract of fruits of Tribulus terrestris was formulated as mouth dissolving tablets (MDTs) by full factorial design at 32 levels and prepared by direct compression method using super integrants like sodium starch glycolate and cross povidone. Furthermore, the tablet was evaluated for thickness, hardness, weight variation, wetting time, disintegration time, and in vitro drug release study. Results: The tablets were analyzed for a variety of characteristics, such as hardness (2.4-2.9 kg/cm2), friability (0.33-1.7%), disintegration time (20-34 s), drug content (95.32-99.09%), water uptake ratio (26-48%), wetting time (29-69 s), and in vitro drug release illustrated in 5 min (99.04-68.21%). There was no interaction between both the drug and the polymer, according to FTIR and DSC studies. Conclusion: The research revealed that Tribulus terrestris fruits extract can be designed, developed and fabricated into mouth dissolving tablet for the treatment of hypertension with improved bioavailability and expected patient compliance.

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Section: In Vitro Drug Release Study Of Formulation (F1-f9)mentioning

confidence: 99%

Design, Development and Fabrication of Mouth-Dissolving Tablets Containing Extract of Tribulus Terrestris for the Treatment of Hypertension

et al. 2023

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“…Place one tablet in each of the 6 tubes of the basket. Add a disc to each tube and run the apparatus using 0.1 N HCl (pH 1.2) maintained at 37 ± 2 °C as the immersion liquid 20,21 .…”

Section: In-vitro Disintegration Timementioning

confidence: 99%

Untitled

2020

IJPSR

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Better patient compliance can be achieved using a combination of two drugs compared to a single drug. The main objective of the present research work has been done to prepare fast dissolving tablets of Nebivolol HCl (NEB) and Valsartan (VAL) using super disintegrating agents. Solid dispersions of VAL were prepared with Mannitol to improve the solubility and release behavior in dissolution fluid. Fast Dissolving tablets of NEB and VAL were formulated by employing the direct compression method. The prepared fast dissolving tablets were evaluated for various parameters like weight variation, hardness, friability, disintegration time, drug content, wetting time, in-vitro drug release, FTIR, DSC studies and short term stability studies. It was found that ratio 1:1 (VAL: Mannitol) shown satisfactory drug release compared to other prepared solid dispersion. Pre-formulation studies of both drugs were performed. The FTIR and DSC studies revealed that there is no chemical interaction with excipients. Percentage weight variation and drug content uniformity were found to be within the approved range of all the formulations. Evaluation parameters like hardness and friability indicated good mechanical resistance of the tablets for all the formulations. The in-vitro release studies showed that 99.6% of NEB and 99.5% VAL within 90 sec. Overall, in the formulations prepared by the direct compression method, F13, which contains 6% CCS as super disintegrants release 99% of (NEB and VAL) in 2 min was found to be the best formulation. The results concluded that fast dissolving tablets of NEB and VAL showing enhanced dissolution might lead to improved bioavailability and effective therapy for hypertension.

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“…Forty one and were analysed spectrophotometrically at λ max of 486 nm. The readings were taken in triplicate [13,14] .…”

Section: Drug Releasementioning

confidence: 99%

Design, Optimization and Evaluation of Chewable Tablets of Clarithromycin using Ion Exchange Resins

Dasankoppa¹,

Sholapur²,

Swamy³

et al. 2016

pharmaceutical-sciences

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Fatima, et al.: Chewable Tablets with Ion Exchange ResinsIon exchange resins are water-insoluble, cross-linked polymers containing salt-forming groups in repeating positions on the polymer chain. Bitter cationic drugs get adsorbed on to weak cationic exchange resins of carboxylic acid functionality like Indion 204, Indion 234 and Tulsion 335 to forms non-bitter complexes. The present investigation aims at taste masking of the bitter clarithromycin using ion exchange resins, which forms complexes, inhibiting its release in saliva. The drug-resin complex loading process was optimized for the content of resin, activation, swelling time, stirring time, influence of pH and temperature for maximum drug loading and was subjected to differential scanning calorimetry to confirm the complex formation. These complexes were used to prepare chewable tablets and to evaluate the taste. Acid-activated resins comprising of Indion 204, Indion 234 and Tulsion 335 with drug:resin ratio of 1:2, stirred in solution of pH 7-8 at 70° for 6 h had a maximum drug loading and masked the bitter taste of clarithromycin. Differential scanning calorimetry of the drug-resin complex revealed that there was interaction leading to complex formation. The drug-resin complex was formulated into chewable tablet formulations (F1-F9) and evaluated. Various pre-and post-compression parameters were found to be within permissible limits. Formulations F3, F6 and F9 containing 1:2 ratios of drug-resin complex of Indion 204, Indion 234 and Tulsion 335 revealed maximum taste masking. This was further confirmed by treatment of taste evaluation scores of the volunteers by ANOVA, Dunnets multiple comparison test and Tukey's multiple comparison test. All the three optimized formulations had a significant difference of P<0.001 when compared to control F10. F6 formulation was widely accepted. Ion exchange complexation could efficiently mask the bitter taste of clarithromycin and achieve palatable taste suitable for paediatric use.

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In Vitro evaluation of domperidone mouth dissolving tablets

Cited by 7 publications

References 5 publications

Design, Development and Fabrication of Mouth-Dissolving Tablets Containing Extract of Tribulus Terrestris for the Treatment of Hypertension

Design, Development and Fabrication of Mouth-Dissolving Tablets Containing Extract of Tribulus Terrestris for the Treatment of Hypertension

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Design, Optimization and Evaluation of Chewable Tablets of Clarithromycin using Ion Exchange Resins

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