In vitro evaluation of antithrombogenicity of hybrid-type vascular vessel models based on analysis of the mechanism of blood coagulation

Kaibara, Makoto; Kawamoto, Yoshitaka; Yanagida, Satoshi; Kawakami, S.

doi:10.1016/0142-9612(95)98129-3

Cited by 15 publications

(4 citation statements)

References 23 publications

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“…The LDF value is closely related to the fluidity of blood sample in the tube [23,24]. As the sensitivity of this rheometer is very high [25], the time of onset of coagulation can be determined from the initial change in LDF, which corresponds to the initiation of clot formation [26]. The maximum value of wall shear rate induced by blood flow in the polypropylene tube was estimated to be less than 1/s [14].…”

Section: Rheological Measurement Of Coagulationmentioning

confidence: 99%

Rheological analyses of coagulation of blood from different individuals with special reference to procoagulant activity of erythrocytes

Kaibara

Iwata

Ujiié

et al. 2005

Blood Coagulation &Amp; Fibrinolysis

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In our previous papers, we reported that factor IX (FIX), when activated by erythrocyte membranes, causes coagulation. We have identified and characterized the FIX-activating enzyme located in normal human erythrocyte membranes. In this paper, to examine physiological and pathological significances of procoagulant activity of erythrocytes, coagulation of blood obtained from different individuals was analyzed by means of a rheological technique. In more than 65% of subjects including normals and patients, the initiation of coagulation seemed to be governed by erythrocytes. Coagulation of whole blood and platelet-free plasma supplemented with erythrocytes had a tendency to occur rapidly in the elderly. It was suggested that the concentration of FIX-activating enzyme on erythrocyte membranes for aged donors was somewhat higher than that for young ages. Propagation reactions on erythrocyte membranes (i.e. factor X activation leading to thrombin generation after FIX activation) was slower than that on platelet membranes. Moreover, the propagation reaction on erythrocyte membranes was greatly dependent on individuals, whereas that on platelet membranes was not so much. Our study demonstrates that the activation of FIX by erythrocytes and subsequent propagation reaction on platelet membranes may be important for initiating and controlling blood coagulation reactions.

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Section: Rheological Measurement Of Coagulationmentioning

confidence: 99%

Rheological analyses of coagulation of blood from different individuals with special reference to procoagulant activity of erythrocytes

Kaibara

Iwata

Ujiié

et al. 2005

Blood Coagulation &Amp; Fibrinolysis

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“…It is commonly agreed that human blood should be used for in vitro tests whenever possible 12, 13. Platelet activation and thrombus formation should be considered to assess accurately thrombogenicity of biomaterials 14.…”

Section: Introductionmentioning

confidence: 99%

In vitro blood compatibility of modified PDMS surfaces as superhydrophobic and superhydrophilic materials

Khorasani

Mirzadeh

2003

J of Applied Polymer Sci

119

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ABSTRACT:The surface of polydimethylsiloxane rubber (PDMS) was irradiated by a CO 2 -pulsed laser. The irradiated surfaces were grafted by hydroxyethylmethacrylate phosphatidylcholine (HEMAPC) by using the preirradiation method. The laser-treated surfaces and HEMAPC-grafted PDMS surfaces were characterized by using a variety of techniques including ATR-FTIR spectroscopy, scanning electron microscopy (SEM), and wettability, which was measured by a water-drop contact angle. Different surfaces with different wettability were prepared. These surfaces, including untreated PDMS (hydrophobic), laser-treated PDMS (superhydrophobic), and HEMAPC-grafted surfaces (superhydrophilic), were used for a platelet adhesion study. Results from in vitro testing indicated that chemical structures, such as negative-charge polar groups and wettability, are important factors in blood compatibility of these surfaces and the superhydrophilic (the most wettable) and the superhydrophobic (the most unwettable) of modified PDMS surfaces have excellent blood compatibility compared to the unmodified PDMS.

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“…Residual hemoglobin of broken erythrocytes is used as a marker of near-surface thrombogenesis in recalcified whole blood (method B). The dynamics of changes in the viscoelastic properties of blood during coagulation is detected by the methods of thromboetastography [6], viscosimetry [10], or using an oscillating rheometer [7] (method C).…”

Section: Comparative Efficiency Of Hematologic Methods For Determininmentioning

confidence: 99%

Comparative efficiency of hematologic methods for determining procoagulant activity of biomedical materials

Немец

Sevast'yanov

1999

Biomed Eng

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In vitro evaluation of antithrombogenicity of hybrid-type vascular vessel models based on analysis of the mechanism of blood coagulation

Cited by 15 publications

References 23 publications

Rheological analyses of coagulation of blood from different individuals with special reference to procoagulant activity of erythrocytes

Rheological analyses of coagulation of blood from different individuals with special reference to procoagulant activity of erythrocytes

In vitro blood compatibility of modified PDMS surfaces as superhydrophobic and superhydrophilic materials

Comparative efficiency of hematologic methods for determining procoagulant activity of biomedical materials

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