In vitro evaluation of antibacterial and antioxidant activities of the essential oil and methanol extract of endemic Zataria multiflora Boiss

Sharififar, Fariba; Moshafi, Mohammad Hassan; Mansouri, Shahla; Khodashenas, M.; Khoshnoodi, M.

doi:10.1016/j.foodcont.2006.04.002

Cited by 308 publications

(192 citation statements)

References 22 publications

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“…Humans have realized and used their beneficial effects. With the increase in population and the urban growth and reduced use of synthetic drugs, many of these of medicinal herbs have been replaced (13). The increase of antibiotic resistance is a serious problem worldwide.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial Effects of Origanum vulgare Essence Against Multidrug-Resistant Acinetobacter baumannii Isolated From Selected Hospitals of Tehran, Iran

Saghi

Bahador²,

Khaledi³

et al. 2015

Avicenna J Clin Microbiol Infect

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Background: Infection due to Acinetobacter baumannii has become a significant challenge to modern healthcare systems. The rapid emergence and global dissemination of A. baumannii as a major nosocomial pathogen is remarkable and it demonstrates its successful adaptation to the 21st century hospital environment. Recent studies have discussed about essential oil of Origanum vulgare against a range of bacteria, including various species of Staphylococcus, Pseudomonas, Bacillus and Escherichia coli. Objectives: The present study aimed to investigate the inhibitory effects O. vulgare essence against multidrug-resistant (MDR) strains of A. baumannii from selected hospitals in Tehran, Iran. Materials and Methods: This oil was obtained using the hydrodistillation method and analyzed by gas chromatography mass spectrography (GC/MS). The antimicrobial activity against MDR isolates was achieved using disc diffusion method and macro-broth dilution assay. Results: Analysis of the essential oil revealed the presence of pulegone (68.59%) piperitone (7.8%), piperitenone (7.8%), 1, 8-cineole (1.3%), and carvacrol (1.6%) as the major components. The results showed a significant activity against MDR A. baumannii with inhibition zones and minimal inhibitory concentration values in the ranges of 7-15 mm and 20-35 µL/mL respectively. Conclusions: This investigation showed that the essence oil of O. vulgare had a potent antimicrobial activity against MDR A. baumannii. Further research is required to evaluate the practical values of therapeutic applications.

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Section: Discussionmentioning

confidence: 99%

Antibacterial Effects of Origanum vulgare Essence Against Multidrug-Resistant Acinetobacter baumannii Isolated From Selected Hospitals of Tehran, Iran

Saghi

Bahador²,

Khaledi³

et al. 2015

Avicenna J Clin Microbiol Infect

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“…(Lamiaceae) has been used for relief of gastric pains and irritable bowel syndrome in traditional medicine. The essential oil of the plant has shown high antioxidant and free radical scavenging effect in vitro and in vivo (Sharififar et al, 2007). The inhibitory effects of essential oil of Z. multiflora against wide range of Grampositive and Gram-negative bacteria, fungi, and parasites have been reported (Azadbakht et al, 2003;Fazeli et al, 2007;Khosravi et al, 2008;Ravanshad & Dastgheib, 2007).…”

Section: Zataria Multifloramentioning

confidence: 99%

Medicinal plants in the treatment ofHelicobacter pyloriinfections

Safavi

Shams-Ardakani

Foroumadi

2014

Pharmaceutical Biology

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Context: Helicobacter pylori is a small, spiral, Gram-negative bacillus that plays a role in the pathogenesis of a number of diseases ranging from asymptomatic gastritis to gastric cancer. Schedule compliance, antibiotic drug resistance, and side-effects of triple or quadruple therapy have led to research for novel candidates from plants.Objective: The purpose of this paper is to review the most potent medicinal plants of recently published literature with anti-H. pylori activity. For centuries, herbals have been used by traditional healers around the world to treat various gastrointestinal tract disorders such as dyspepsia, gastritis, and peptic ulcer disease. The mechanism of action by which these botanicals exert their therapeutic properties has not been completely and clearly elucidated. Anti-H. pylori properties may be one of the possible mechanisms by which gastroprotective herbs treat gastrointestinal tract disorders. Materials and methods: Electronic databases such as PubMed, Google scholar, EBSCO, and local databases were explored for medicinal plants with anti-H. pylori properties between 1984 and 2013 using key words ''medicinal plants'' and ''Helicobacter pylori'' or ''anti-Helicobacter pylori''. Results: A total of 43 medicinal plant species belonging to 27 families including Amaryllidaceae,

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“…After incubation of dishes at 37 °C for 24 h, inhibition zone diameter as measured in mm. 8,9 Hypoglycemic Activity of Aqueous Extract 3 groups of 5 rats each were formed. Animals fasted for 14 h prior to experiment; the 1st group received distilled water, the 2nd group received glibenclamid (substance with hypoglycemic effect) at a dose of 3 mg/Kg body weight and the third group received the aqueous extract of Thymelaea microphylla at a dose of 250 mg/Kg body weight.…”

Section: Raa%=(a Sample/abht)×100mentioning

confidence: 99%

Antioxidant, Antibacterial and Hypoglycemic Activity of Extracts from Thymelaea microphylla Coss. et Dur.

Dahamna¹,

Dehimi²,

Merghem³

et al. 2015

Intl J Phyto Natu Ingrd

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The objective of this study was to evaluate different biological activities of aqueous and ethanolic extracts from Thymelaea microphylla. Antioxidant capacity was determined using two methods: 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, and the inhibition of lipid peroxidation using the β-carotene/linoleate model system. Disc diffusion method was used to evaluate the antibacterial activity on four different strains. Hypoglycemic effect of aqueous extract was tested in rats. Aqueous and ethanolic extracts showed a good antioxidant activity with IC50 of 0.1 and 0.2 mg/ml in DPPH test, and RRA% of 46.40% and 77.86% in β-carotene/linoleate assay respectively. Both extracts had no antibacterial effect on studied strains. A single administration of aqueous extract at a dose of 250 mg/kg bodyweight caused a very significant decrease in blood glucose level in rat. Keywords: Antibacterial activity, β-carotene/linoleate, DPPH, Hypoglycemic activity, Thymelaea microphylla Please cite this paper as: Dahamna S, Dehimi K, Merghem M, et al. Antioxidant, antibacterial and hypoglycemic activity of extracts from Thymelaea microphylla Coss. et Dur.

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In vitro evaluation of antibacterial and antioxidant activities of the essential oil and methanol extract of endemic Zataria multiflora Boiss

Cited by 308 publications

References 22 publications

Antibacterial Effects of Origanum vulgare Essence Against Multidrug-Resistant Acinetobacter baumannii Isolated From Selected Hospitals of Tehran, Iran

Antibacterial Effects of Origanum vulgare Essence Against Multidrug-Resistant Acinetobacter baumannii Isolated From Selected Hospitals of Tehran, Iran

Medicinal plants in the treatment ofHelicobacter pyloriinfections

Antioxidant, Antibacterial and Hypoglycemic Activity of Extracts from Thymelaea microphylla Coss. et Dur.

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