In vitro Equivalence Studies/Comparative Assessment of Generic Metronidazole Tablets Commercially Available in Lagos, Nigeria

Ilomuanya, Margaret O.; Mbaneme, Nabuogo A.; Okubanjo, Omotunde; Ofokansi, KC

doi:10.9734/bjpr/2015/18572

Cited by 4 publications

(3 citation statements)

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“…Another study resulted only 8 out of 11 metronidazole tested products resulted as very rapidly dissolving as defined by the WHO, whereas 2 of them failed f 2 acceptance criteria in pH 6.8 7 . In-vitro dissolution was used in several studies for therapeutic equivalence of metronidazole tablets, a study from Nigeria showed 8 out of 12 tested brands of metronidazole in-vitro equivalent 17 , a study published revealed all tested brands found equivalent and can be use as substitution 18 .…”

Section: Discussionmentioning

confidence: 99%

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2017

IJPSR

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ABSTRACT:Metronidazole is a class I drug in biopharmaceutics classification system (BCS) and widely used in Pakistan, various available brands in local markets along with innovator brand to serve a large population. In-vitro dissolution testing can be used as waiver for in-vivo bioequivalence studies of generic brand interchangeability for Class I drugs i.e., highly soluble and highly permeable. The objective of the study was to determine immediate release tablet dosage form of metronidazole to fulfil the requirements of 85% drug release in pH 1.2, 4.5 and 6.8 recommended by WHO. In this study physicochemical quality attributes, price comparison and dissolution studies were performed on three available brands of metronidazole 400 mg, one of them is innovator brand and the two others are test brands. The dissolution profiles were compared by using similarity factor (f 2 ) that were analyzed by UV spectrophotometer at 278 nm wavelength. The test brands were very cheap in cost as compared to innovator brand but both the test brand were failed the dissolution test in all mediums and only innovator brand showed 85% drug release within 30 minutes. The study suggested test brands are not equivalent or similar to innovator brand. In-vivo bioequivalence studies are thus needed for test brands to strengthen this invitro finding.

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Section: Discussionmentioning

confidence: 99%

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2017

IJPSR

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“…Thus, drug absorption depends on the ability of the drug to go into solution/dissolution after oral administration and to then permeate the biological membrane of the gastrointestinal tract. Therefore, the dissolution process is critical in the prediction of the in vivo behavior of the drug ( Ilomuanya et al, 2015 ). MTZ is rapidly absorbed after oral administration, with a bioavailability approximating 100 % ( Aleanizy et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Impacts of storage conditions on the dissolution performance of commercial metronidazole tablets available in Saudi Arabia

Aldosari,

Al-Mutairi,

Almurshedi

et al. 2024

Saudi Pharmaceutical Journal

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“…These bacteria are commonly found on raw foods like salads, eggs, beef, vegetables, cheese, ice cream, unpasteurized milk, fish, fresh fruits, canned foods, mushrooms etc. [6,7]. Incubation periods of the various organisms causing food poison differ.…”

Section: Introductionmentioning

confidence: 99%

Re-thinking Metronidazole: Anti-microbial Synergism of Hexane Extracts of Garcinia kola and Aframomum melegueta

Odimegwu

Asabisi

Sodeinde

et al. 2020

JAMB

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Aims: This research evaluates knowledge, attitudes, and practice with regard to food poisoning treatment. It compares the antimicrobial effects of Garcinia kola (Gk) and Aframomum melegueta (Am) seeds with Metronidazole and Gentamicin as standards. Study Design: A survey with questionnaires was carried out among community Pharmacists in Lagos, Nigeria on drug of choice for suspected food poisoning and the responses analyzed. Hexane extracts of Gk and Am seeds were used on selected microbials that cause food poisoning. Place and Duration of Study: Department of Pharmacognosy; Phytochemistry Laboratory and Department of Pharmaceutics and Pharmaceutical Technology; Pharmaceutical Microbiology Laboratory, Faculty of Pharmacy. University of Lagos. Methodology: Agar diffusion assays were carried out using and using Gk and Am with Metronidazole and Gentamicin as controls. Gas chromatography and Mass spectroscopy of the extracts was also carried out to ascertain the possible active phytocomponents. Results: Our discovery on knowledge showed that 98.6% of the interviewed Pharmacists use Metronidazole for food poisoning treatment. 41.7% of the respondents prescribe Ciprofloxacin while 66.7% prescribed Tetracycline as adjunct medications. Gk and Am exerted powerful anti-microbial effects in a dose dependent manner. Gk on S. typhi showed 1.4-1.7 cm zone of inhibition (zi) at 200mg/ml and with E. coli, 1.2 cm at same concentration. Am with S. typhi showed1.2-1.8 cm and E. coli 1.5 cm zi at same concentration too, much better than Gk. Their mixture for the synergistic experiments had 2.0-2.2 cm and E. coli, 2.4 cm zi at 200 mg/ml, the best performance of the extracts as anti-infective agents against food poisoning. 19 compounds were discovered through GC/MS in Gk and 31 in Am. They each exerted more antimicrobial effects than Metronidazole and their mixture used for synergistic experiments compared favorably with Gentamicin. Conclusion: Hexane extracts of Gk and Am are good alternatives for the treatment of food poisoning. The study encourages further drug discovery research in order to ascertain the particular bioactive compounds in the extracts responsible for their powerful antimicrobial actions. Metronidazole is not the drug of choice for food poisoning management.

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In vitro Equivalence Studies/Comparative Assessment of Generic Metronidazole Tablets Commercially Available in Lagos, Nigeria

Cited by 4 publications

References 0 publications

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Impacts of storage conditions on the dissolution performance of commercial metronidazole tablets available in Saudi Arabia

Re-thinking Metronidazole: Anti-microbial Synergism of Hexane Extracts of Garcinia kola and Aframomum melegueta

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