In vitro efficacy of phytotherapeutics suggested for prevention and therapy of urinary tract infections

Anthocyanins in Blueberries Grown in Hot Climate Exert Strong Antioxidant Activity and May Be Effective against Urinary Tract Bacteria

“…In this sense, Cochrane meta-analyses, including clinical studies, showed a lack of positive trials [ 16 , 18 ], while the Spanish Urological Association concluded that there are no significant benefits compared with placebo, except for a very small effect in certain population subgroups [ 94 ]. However, the positive results in this and other in vitro studies [ 50 , 57 , 58 ] seem to point out that the actual optimal extraction procedures, mixture formulations, dosage and bioavailability are not yet clear [ 88 ]. Moreover, anthocyanins in blueberries might target each individual uropathogenic strain in the wider spectrum of UTI pathogens differently, varying their response to treatment [ 88 ].…”

“…They decreased the cell surface hydrophobicity of S. Typhimurium, together with its auto-aggregation, cellular motility, colonisation and invasion capabilities [ 87 ]. Similarly, compounds in purified proanthocyanins from cranberry extracts inhibited the agglutination of E. coli and K. pneumoniae [ 88 ]. However, this effect was strain- specific and dose-dependent [ 53 , 88 ].…”

“…Similarly, compounds in purified proanthocyanins from cranberry extracts inhibited the agglutination of E. coli and K. pneumoniae [ 88 ]. However, this effect was strain- specific and dose-dependent [ 53 , 88 ]. Blueberry extracts affected the growth of E. coli and P. aeruginosa , and they were able to significantly inhibit their biofilm formation and bacterial adhesion [ 50 ]—both important factors in their surface colonisation and infection [ 54 ].…”

“…It appears that the concentration and type of anthocyanins reaching the urine of UTI patients might be insufficient to exert a quantifiable effect [ 88 ]. In this sense, Cochrane meta-analyses, including clinical studies, showed a lack of positive trials [ 16 , 18 ], while the Spanish Urological Association concluded that there are no significant benefits compared with placebo, except for a very small effect in certain population subgroups [ 94 ].…”

A Randomized Clinical Trial to Evaluate the Effect of Canephron N in Comparison to Ciprofloxacin in the Prevention of Postoperative Lower Urinary Tract Infections after Midurethral Sling Surgery

“…The main ingredients of the herbal, medicinal product Canephron N are pulverized rosemary leaves, century herbs, and lovage roots. In an in vitro study, the administration of rosemary extracts showed a strong bacteriostatic effect in growth assays for such strains as Escherichia coli , Klebsiella pneumoniae , Proteus mirabilis , Enterobacter cloacae , Citrobacter freundii , and Pseudomonas aeruginosa [ 18 ]. Research conducted on animal models showed that after oral administration Canephron is effective in the reduction of inflammation and hyperalgesia in experimental cystitis and hyperalgesia with induced prostatitis.…”