In vitro efficacy of isoflavonoids and terpenes against Leishmania (Leishmania) infantum and L. amazonensis

Araújo, Iasmin Aparecida Cunha; Paula, Renata Cristina de; Alves, Ceres Luciana; Faria, Karen Ferraz; Oliveira, Marco Miguel de; Mendes, Gabriela Gonçalves; Dias, Eliane Maritns Ferreira Abdias; Oliveira, Alaı́de Braga de; Silva, Sydnei Magno da

doi:10.1016/j.exppara.2022.108383

Cited by 5 publications

(3 citation statements)

References 29 publications

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“…In an in vivo murine model of cutaneous leishmaniasis using L. tropica , (−)-α-bisabolol was able to reduce lesion size and parasite burden, similar to HABTO- or ICTX-treated mice. Also, (−)-α-bisabolol was more effective than Glucantime in a murine model of visceral leishmaniasis . In an in vivo assay performed with ursolic acid for cutaneous leishmaniasis, this terpene reduced lesion size and parasite load .…”

Section: Resultssupporting

confidence: 73%

“…Also, (−)-α-bisabolol was more effective than Glucantime in a murine model of visceral leishmaniasis. 32 In an in vivo assay performed with ursolic acid for cutaneous leishmaniasis, this terpene reduced lesion size and parasite load. 25 These results were similar to when HABTO or ICTX was used to treat mice in our in vivo model of cutaneous leishmaniasis.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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Antiparasitic Activity of Two Natural Terpenes from Salvia cuspidata against Leishmania amazonensis

et al. 2023

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Leishmaniasis is a neglected disease caused by flagellated parasites of the Leishmania genus affecting more than 10 million people worldwide. Current treatments for leishmaniasis involve the administration of poorly tolerated drugs with toxic side effects in patients. There is an imperative necessity for novel compounds to treat this disease. One of the most used strategies in the search for different antiparasitic compounds is the screening of purified plant molecules. The diterpenes 12-hydroxy-11,14-diketo-6,8,12-abietatrien-19,20-olide (HABTO) and 5-epi-icetexone (ICTX) isolated from Salvia cuspidata were shown to be effective against Leishmania amazonensis in vitro and in vivo. They displayed an antiproliferative effect against L. amazonensis promastigotes. They also induce an increase in ROS levels and affect the mitochondrial activity of parasites. HABTO and ICTX in an in vivo model of cutaneous leishmaniasis decrease footpad swelling, parasite load, and splenic index. Moreover, they induce significant reduction in the O.D. of total anti-Leishmania IgG and IgG1 subtype antibody responses against L. amazonensis compared to the PBS group but maintain high levels of IgG2a. This suggests that in HABTO-or ICTX-treated mice, there is a slowdown in the progression of the disease. These terpenes could be considered as possible novel antileishmanial agents against L. amazonensis and thus treat cutaneous leishmaniasis.

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Section: Resultssupporting

confidence: 73%

Section: ■ Results and Discussionmentioning

confidence: 99%

Antiparasitic Activity of Two Natural Terpenes from Salvia cuspidata against Leishmania amazonensis

et al. 2023

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“…Daidzein and genistein are commonly known as phytoestrogens because of their oestrogenic activity in various models of animals. Tey have antidiabetic, antioxidant, and also effective against Leishmania infantum, cytotoxicity against Hep G2 cell lines, and Leishmania amazonensis [24,25]. Isofavonoids are essential for preventing cataract development in diabetic and hypertensive animal models [26].…”

Section: Flavonolsmentioning

confidence: 99%

A Comprehensive Review of the Pharmacological Importance of Dietary Flavonoids as Hepatoprotective Agents

Gajender

Mazumder

Sharma

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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The liver is a crucial organ that is involved in various kinds of metabolic activity and a very stable accessory gland for the digestive system. Long-term or persistent inflammation and oxidative stress due to any reasons have a substantial impact on the beginning and continuation of chronic diseases such as hepatocellular carcinoma, liver cirrhosis, liver fibrosis, and other hepatic conditions. There are many sources which can help the liver to be healthy and enhance its metabolic potential of the liver. Since the diet is rich origin of bioactive along with antioxidant chemicals including flavonoids and polyphenols, it can control different stages of inflammation and hepatic diseases. Numerous food sources, notably vegetables, nuts, fruits, cereals, beverages, and herbal medicinal plants, are rich in bioactive chemicals called flavonoids and their derivatives like Flavones, Anthocyanins, Iso-flavonoid, Flavanones, Flavanols, and Flavan-3-ols. Most recently occurred research on flavonoids has demonstrated that they can regulate hepatoprotective properties. This is because they are essential parts of pharmaceutical and nutraceutical products due to their hepatoprotective, antioxidative, and immune-modulating characteristics. However, the characteristics of their hepatoprotective impact remain unclear. The purpose of this comprehensive review is to survey the flavonoid structure and enriched sources for their hepatoprotective and antioxidant effects concerning liver toxicity or injury.

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A step-economical divergent approach to isoflavenes based on Suzuki–Miyaura cross coupling of a 3-boryl-2H-chromene with aryl bromides: application to total synthesis of isoflavonoid natural products

Uchida

Takikawa

Kang

2023

Bioscience, Biotechnology, and Biochemistry

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We present a step-economical divergent synthetic approach for isoflavene derivatives using the Suzuki–Miyaura cross coupling of a 3-boryl-2H-chromene and three aryl bromides. 3-boryl-2H-chromene, which is not a well-explored species, was prepared via Miyaura–Ishiyama borylation of a 3-chloro-2H-chromene obtained through a Claisen rearrangement cyclization cascade reaction. Further conversion of the cross coupling products, three isoflavene derivatives, afforded three isoflavonoid natural products with one or two additional reaction steps.

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In vitro efficacy of isoflavonoids and terpenes against Leishmania (Leishmania) infantum and L. amazonensis

Cited by 5 publications

References 29 publications

Antiparasitic Activity of Two Natural Terpenes from Salvia cuspidata against Leishmania amazonensis

Antiparasitic Activity of Two Natural Terpenes from Salvia cuspidata against Leishmania amazonensis

A Comprehensive Review of the Pharmacological Importance of Dietary Flavonoids as Hepatoprotective Agents

A step-economical divergent approach to isoflavenes based on Suzuki–Miyaura cross coupling of a 3-boryl-2H-chromene with aryl bromides: application to total synthesis of isoflavonoid natural products

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