In vitro effects of the Cimicifuga racemosa extract BNO 1055

Jarry, Hubertus; Metten, Maria; Spengler, Barbara A.; Christoffel, Volker; Wuttke, W.

doi:10.1016/s0378-5122(02)00346-8

Cited by 97 publications

(65 citation statements)

References 22 publications

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“…An additional hypothesis is that the compounds in black cohosh interact with a third estrogen receptor, ERγ, yet to be identified in humans but recently reported in teleost fish (Jarry et al, 2003). Metabolic conversion of precursor molecules, serotonin receptor blocking activity and dopaminergic compounds have also been suggested as potential mechanisms of action for black cohosh (Jarry et al, 2003). Currently, black cohosh is in a clinical trial at Columbia University and the University of Illinois at Chicago for the treatment of menopausal hot flashes, as well as assessment of cognitive function and bone metabolism.…”

Section: Black Cohoshmentioning

confidence: 99%

Phytoestrogens: a review of the present state of research

Ososki

Kennelly

2003

Phytotherapy Research

401

278

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Phytoestrogens are a diverse group of plant-derived compounds that structurally or functionally mimic mammalian estrogens and show potential benefits for human health. The number of articles published on phytoestrogens has risen dramatically in the past couple decades. Further research continues to demonstrate the biological complexity of phytoestrogens, which belong to several different chemical classes and act through diverse mechanisms. This paper discusses the classification of phytoestrogens, methods of identification, their proposed mechanisms of action and botanical sources for phytoestrogens. The effects of phytoestrogens on breast and prostate cancers, cardiovascular disease, menopausal symptoms and osteoporosis will also be examined including research on benefits and risks.

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Section: Black Cohoshmentioning

confidence: 99%

Phytoestrogens: a review of the present state of research

Ososki

Kennelly

2003

Phytotherapy Research

401

278

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“…Indeed, Black Cohosh does not bind neither to α nor β receptors [26,27], and it inhibits the proliferation of MCF-7 cells, that are the human breast cancer cell lines more responsive to the estrogenic action [28][29][30].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Cimicifuga Racemosa on Menopausal Symptoms in Women with Breast Cancer

Stracquadanio¹,

Giunta²,

D’Agati³

et al. 2017

Gynecol Obstet

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The Hormone Replacement Therapy (HRT) is the "first-line therapy" for women with moderate / severe menopausal symptoms (hot flashes, profuse sweating, insomnia, osteoporosis).However, when the symptomatology is lighter or there are contraindications to HRT (breast disease, cardiovascular disease, thrombophilic diathesis, smoke, etc), woman can benefit from some preparations such as phytoestrogens and Cimicifuga racemosa. At present there are insufficient data regarding the efficacy and safety of phytoestrogens in women with breast cancer: because this tumour disease is hormone-dependent, phytoestrogens should be considered contraindicated in patients survived to the disease.Our study assessed both the effectiveness of a new compound containing Cimicifuga racemosa, Agnus-Castus, Ginger, Hyaluronic acid and Zinc on the neurovegetative menopausal symptoms (hot flashes, profuse sweating, insomnia) and its safe use in patients with breast cancer.The results have shown that this compound is an excellent alternative to estrogen treatment of menopausal neurovegetative symptoms, even for patients with breast cancer who cannot take HRT or phytoestrogens.

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“…Black cohosh, specifically, iCR has been shown to have an impact on brain via modulating neurotransmitter receptors in vitro [20][21][22][23] and in vivo in rodents [14,24] as well as in humans [25,26]. There is pharmacodynamic evidence for bioactivity of iCR-ingredients in brain in vivo, i.e.…”

Section: Discussionmentioning

confidence: 99%

Effects of black cohosh on estrogen biosynthesis in hippocampus of non-human primates ex vivo in vitro and in human neuroblastoma cells in vitro

et al. 2016

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Background: Estrogens have neuroprotective properties. The aim of the study was to assess the impact of an isopropanolic extract of Cimicifuga racemosa (iCR), 17ß-estradiol (E2), testosterone (T) and Tibolone's 3α-OH metabolite (Org4094) on local estrogen formation in hippocampus tissue from non-human primates ex vivo in vitro and human neuroblastoma cells (SH-SY5Y) in vitro. Methods: SH-SY5Y cells were incubated in RPMI 1640 medium containing 5 % steroid-depleted fetal calf serum for 3 days, and subsequently incubated in absence or presence of iCR at 10 μg/ml (n = 5) and 1 μg/ml (n = 5), E2 at 10 −8 M (n = 5), and 10 −6 M (n = 5), or T at 10 −8 M (n = 5), and 10 −6 M (n = 5), respectively, at 37°C for either 24 h or directly in cell extracts. Hippocampus tissue from healthy female cynomolgus macaques (n = 14) was homogenized and treated with iCR, E2 and Org4049 accordingly. STS activity was evaluated by incubating homogenized brain cells and tissue with [3H]-estrone sulfate and separating the products estrone (E1) and E2 by thin layer chromatography. STS activity was expressed as total estrogen formation (E1 + E2) fmol/mg of protein/min. Statistical comparisons were made using unpaired T-Test for comparing two sets of data and ANOVA to compare many groups at once. A p value < 0.05 was considered to be significant different. Results: Basal total estrogen formation was significantly higher in proliferative SH-SY5Y cells (1350.06 ± 109 E1 + E2 fmol/mg of protein/min) compared to hippocampus tissue (37.83 ± 3.9 E1 + E2 fmol/mg of protein/min; p < 0.01). ICR exerted a bidirectional action with an immediate strong inhibitory effect being followed by a stimulation of STS activity (85 % increase). E2 had a bidirectional dose-dependent long-term effect on STS activity (−23 % reduction and 18 % increase). T and Org4094 had an immediate strong inhibitory effect on STS activity that further maintained with 24 h T treatment (30 % decrease). Conclusions: Local estrogen formation within brain cells and tissue may be modulated by black cohosh, 17ß-estradiol, testosterone, and Tibolone's 3α-OH metabolite, respectively. The clinical implication of this finding has to be elucidated.

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In vitro effects of the Cimicifuga racemosa extract BNO 1055

Cited by 97 publications

References 22 publications

Phytoestrogens: a review of the present state of research

Phytoestrogens: a review of the present state of research

Efficacy of Cimicifuga Racemosa on Menopausal Symptoms in Women with Breast Cancer

Effects of black cohosh on estrogen biosynthesis in hippocampus of non-human primates ex vivo in vitro and in human neuroblastoma cells in vitro

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