In Vitro Effects of Tartary Buckwheat-Derived Nanovesicles on Gut Microbiota

Liu, Yü; Tan, Mao-Ling; Zhu, Wenjing; Cao, Yanan; Peng, Lianxin; Yan, Zhuyun; Zhao, Gang

doi:10.1021/acs.jafc.1c07658

Cited by 26 publications

(20 citation statements)

References 57 publications

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“…The method described by Liu et al (Liu et al, 2022 ) was used to determine the SCFAs content. Briefly, the fermentation broth was centrifuged and added to the anhydrous ethanol in a 1:1 ratio, vortexed, mixed, and centrifuged.…”

Section: Methodsmentioning

confidence: 99%

Isolation and purification of Tartary buckwheat polysaccharides and their effect on gut microbiota

Xiang

Cao

Yang

et al. 2022

Food Science & Nutrition

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Tartary buckwheat (Fagopyrum tataricum) is rich in polysaccharides that can be utilized by the gut microbiota (GM) and provide several health benefits. However, the mechanisms underlying the action of these polysaccharides remain unclear to date. In this study, Tartary buckwheat polysaccharides (TBP) were purified, and five fractions were obtained. The composition of these fractions was determined using ion chromatography. Different TBP components were investigated regarding their probiotic effect on three species of Bifidobacteria and Lactobacillus rhamnosus. In addition, the effect of TBP on GM and short‐chain fatty acids (SCFAs) was evaluated. Results showed that the probiotic effect of TBP fraction was dependent on their composition. The polysaccharides present in different fractions had specific probiotic effects. TBP‐1.0, mainly composed of fucose, glucose, and d‐galactose, exhibited the strongest proliferation effect on L. rhamnosus, while TBP‐W, rich in glucose, d‐galactose, and fructose, had the best promoting effect on Bifidobacterium longum and Bifidobacterium adolescentis growth. Furthermore, TBP‐0.2, composed of d‐galacturonic acid, d‐galactose, xylose, and arabinose, exhibited its highest impact on Bifidobacterium breve growth. The composition of GM was significantly altered by adding TBP during fecal fermentation, with an increased relative abundance of Lactococcus, Phascolarctobacterium, Bacteroidetes, and Shigella. Simultaneously, the level of SCFA was also significantly increased by TBP. Our findings indicate that Tartary buckwheat can provide specific dietary polysaccharide sources to modulate and maintain GM diversity. They provide a basis for Tartary buckwheat commercial utilization for GM modulation.

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Section: Methodsmentioning

confidence: 99%

Isolation and purification of Tartary buckwheat polysaccharides and their effect on gut microbiota

Xiang

Cao

Yang

et al. 2022

Food Science & Nutrition

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“…Particularly, they can facilitate the growth of partial bacteria such as Firmicutes , Tenericutes , and Lachnospiraceae . Liu et al demonstrated that Tartary buckwheat-derived ELNs can target functional genes related with the physiological processes of Escherichia coli and Lactobacillus rhamnosus , promote the growth of E. coli and L. rhamnosus , and enhance the diversity of intestinal microorganism.…”

Section: Intestinal Barrier Improvementmentioning

confidence: 99%

“…Particularly, they can facilitate the growth of partial bacteria such as Firmicutes, Tenericutes, and Lachnospiraceae. Liu et al 74 demonstrated that Tartary buckwheat-derived ELNs can target functional genes related with the physiological processes of Escherichia coli and Lactobacillus rhamnosus, promote the growth of E. coli and L. rhamnosus, and enhance the diversity of intestinal microorganism. In addition, a similar study carried out by Teng et al 25 reported that miRNAs inside of ginger-derived ELNs were selectively taken up by bacteria of Lactobacillus rhamnosus and further regulated the expression of related bacterial genes included in the improvement of colitis in DSS-induced mouse models.…”

Section: ■ Intestinal Barrier Improvementmentioning

confidence: 99%

Advances in Bioactivity of MicroRNAs of Plant-Derived Exosome-Like Nanoparticles and Milk-Derived Extracellular Vesicles

Yao

Yue

et al. 2022

J. Agric. Food Chem.

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MicroRNA (miRNA) is a class of small noncoding RNA involved in physiological and pathological processes via the regulation of gene expression. Naked miRNAs are unstable and liable to degradation by RNases. Exosome-like nanoparticles (ELNs) secreted by plants and extracellular vesicles (EVs) found in milk are abundant in miRNAs, which can be carried by ELNs and EVs to target cells to exert their bioactivities. In this review, we describe the current understanding of miRNAs in plant ELNs and milk EVs, summarize their important roles in regulation of inflammation, intestinal barrier, tumors, and infantile immunological functions, and also discuss the adverse effect of EV miRNAs on human health. Additionally, we prospect recent challenges centered around ELN and EV miRNAs for interventional applications and provide insights of grain-derived ELNs and miRNAs interventional use in human health. Overall, plant ELNs and milk EVs can transfer miRNAs to mitigate the pathological status of recipient cells by mediating the expression of target genes but may also exert some side effects. More studies are required to elucidate the in-depth understanding of potential interventional effects of ELN and EV miRNAs on human health.

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“…Metal-free PDNPs are environmental friendly, toxic chemical free, cheap, and energy serving ( Kharissova et al, 2019 ; Surendran et al, 2021 ). The potential to derive metal-free NPs with medicinal properties from plants has gained more attention worldwide ( Zhang et al, 2016 ; Saravanan et al, 2021 ; Surendran et al, 2021 ; Liu et al, 2022 ; Nemidkanam and Chaichanawongsaroj, 2022 ). Liu et al (2022) reported the therapeutic ability of metal-free PDNPs on gut microbiota while Xiao et al (2018) highlighted the therapeutic efficacy of metal-free NPs synthesized from 11 edible fruits and vegetables.…”

Section: Alternative Therapeutic Approaches and Strategies For Multid...mentioning

confidence: 99%

“…The potential to derive metal-free NPs with medicinal properties from plants has gained more attention worldwide ( Zhang et al, 2016 ; Saravanan et al, 2021 ; Surendran et al, 2021 ; Liu et al, 2022 ; Nemidkanam and Chaichanawongsaroj, 2022 ). Liu et al (2022) reported the therapeutic ability of metal-free PDNPs on gut microbiota while Xiao et al (2018) highlighted the therapeutic efficacy of metal-free NPs synthesized from 11 edible fruits and vegetables. Saravanan et al (2021) reported the antibacterial efficacy of metal-free NPs derived from Curcuma longa plant against E. coli, S. aurous, K. pneumoniae, and S. epidermidis .…”

Section: Alternative Therapeutic Approaches and Strategies For Multid...mentioning

confidence: 99%

Plant-derived nanoparticles as alternative therapy against Diarrheal pathogens in the era of antimicrobial resistance: A review

et al. 2022

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Diarrhea is a condition in which feces is discharged from the bowels frequently and in a liquid form. It is one of the frequent causes of morbidity and mortality in developing countries. The impact of Diarrhea is worsened by the increasing incidence of antimicrobial resistance among the causative agents, and this is now categorized as a global healthcare challenge. Antimicrobial resistance among Diarrheal pathogens also contributes to extended infection durations, and huge economic loss even in countries with advanced public health policies. The ever-increasing incidence of antimicrobial resistance including the contraindications arising from the administration of antibiotics in some Diarrheal cases highlights a crucial need for the development of novel non-antibiotic alternative agents for therapeutic and biocontrol applications. One such intervention includes the application of plant-derived nanoparticles (PDNPs) with novel antimicrobial properties. Given their small size and large surface area to volume ratio, PDNPs can attack target bacterial cell walls to generate reactive oxygen species that may simultaneously disrupt bacteria cell components such as DNA and proteins leading to cell damage or death. This potential can make it very difficult for pathogenic organisms to develop resistance against these antibacterial agents. In this review, we provide a critical overview on the antimicrobial resistance crisis among Diarrheagenic bacteria. We also discuss the evidence from the existing literature to support the potential associated with the use of PDNPs as alternative therapeutic agents for multidrug resistant and antibiotics administer contraindicated bacteria that are associated with Diarrhea.

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In Vitro Effects of Tartary Buckwheat-Derived Nanovesicles on Gut Microbiota

Cited by 26 publications

References 57 publications

Isolation and purification of Tartary buckwheat polysaccharides and their effect on gut microbiota

Isolation and purification of Tartary buckwheat polysaccharides and their effect on gut microbiota

Advances in Bioactivity of MicroRNAs of Plant-Derived Exosome-Like Nanoparticles and Milk-Derived Extracellular Vesicles

Plant-derived nanoparticles as alternative therapy against Diarrheal pathogens in the era of antimicrobial resistance: A review

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