In vitro Effects of Salicylic Acid on Plasma Paraoxonase 1 Activity

Mouhamed, Dhouha Haj

doi:10.4172/2157-7609.1000148

Cited by 3 publications

(4 citation statements)

References 16 publications

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“…ABCA1 is a membrane transporter abundant in macrophages and plays a crucial role in cholesterol homeostasis, thereby protecting against atherosclerosis [ 36 ]. Salicylic acid (SA) treatment has been reported to prevent complications of atherosclerotic cardiovascular disease such as myocardial infarction and occlusive stroke [ 37 ]. These effects of SA are attributed to its platelet-inhibitory function and stimulation of Paraoxonase 1, an enzyme that protects the serum lipids from oxidation and can reduce macrophage foam cell formation and attenuates atherosclerosis development [ 38 ].…”

Section: Cardioprotective Activitymentioning

confidence: 99%

Therapeutic Potential of Dietary Phenolic Acids

Saibabu

Fatima

Khan

et al. 2015

Advances in Pharmacological Sciences

123

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Although modern lifestyle has eased the quality of human life, this lifestyle's related patterns have imparted negative effects on health to acquire multiple diseases. Many synthetic drugs are invented during the last millennium but most if not all of them possess several side effects and proved to be costly. Convincing evidences have established the premise that the phytotherapeutic potential of natural compounds and need of search for novel drugs from natural sources are of high priority. Phenolic acids (PAs) are a class of secondary metabolites spread throughout the plant kingdom and generally involved in plethora of cellular processes involved in plant growth and reproduction and also produced as defense mechanism to sustain various environmental stresses. Extensive research on PAs strongly suggests that consumption of these compounds hold promise to offer protection against various ailments in humans. This paper focuses on the naturally derived PAs and summarizes the action mechanisms of these compounds during disease conditions. Based on the available information in the literature, it is suggested that use of PAs as drugs is very promising; however more research and clinical trials are necessary before these bioactive molecules can be made for treatment. Finally this review provides greater awareness of the promise that natural PAs hold for use in the disease prevention and therapy.

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Section: Cardioprotective Activitymentioning

confidence: 99%

Therapeutic Potential of Dietary Phenolic Acids

Saibabu

Fatima

Khan

et al. 2015

Advances in Pharmacological Sciences

123

View full text Add to dashboard Cite

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“…ASA intake was found to be associated with positive effects like increased ROS scavenging, encompassed lipoprotein oxidation and improved function of endothelium, which at least partially can be attributed to enhanced PON1 protective function [180]. These findings were confirmed in another study, where PON1 activity was induced by ASA, providing additional protection to prevent cardiovascular diseases and atherosclerosis [181]. Studies on cell cultures indicate that the effect of ASA on PON1 can originate from the induction of PON1 and apoA1 gene expression, probably mediated by AhR gene expression [182].…”

Section: Cardiovascular Drugsmentioning

confidence: 71%

Modulatory Effect of Lifestyle-Related, Environmental and Genetic Factors on Paraoxonase-1 Activity: A Review

Kunachowicz

Ściskalska

Kępińska

2023

IJERPH

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Paraoxonase-1 (PON1) is a calcium-dependent, HDL-bound serum hydrolase active toward a wide variety of substrates. PON1 displays three types of activities, among which lactonase, paraoxonase, arylesterase and phosphotriesterase can be distinguished. Not only is this enzyme a major organophosphate compound detoxifier, but it is also an important constituent of the cellular antioxidant system and has anti-inflammatory and antiatherogenic functions. The concentration and activity of PON1 is highly variable among individuals, and these differences can be both of genetic origin and be a subject of epigenetic regulation. Owing to the fact that, in recent decades, the exposure of humans to an increasing number of different xenobiotics has been continuously rising, the issues concerning the role and activity of PON1 shall be reconsidered with particular attention to growing pharmaceuticals intake, dietary habits and environmental awareness. In the following manuscript, the current state of knowledge concerning the influence of certain modifiable and unmodifiable factors, including smoking, alcohol intake, gender, age and genotype variation on PON1 activity, along with pathways through which these could interfere with the enzyme’s protective functions, is presented and discussed. Since exposure to certain xenobiotics plays a key role in PON1 activity, the influence of organophosphates, heavy metals and several pharmaceutical agents is also specified.

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“…PAs have been widely studied for their protective effects against cardiovascular disorders such as atherosclerosis, ischemia, stroke and hypertension. Cardiopulmonary disorders are among the foremost causes of deaths in both economically developed and developing states [ 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 ]. It was found that CAPE derivatives of caffeic acid at 3 and 15 mg/kg had shown cardio-protective activity against I/R injury in rabbits.…”

Section: Pharmacological Activities Of Pasmentioning

confidence: 99%

“…It was found that SA tended to prevent complications related to cardiovascular diseases such as myocardial infarction and stroke [ 81 ]. The mechanism is to obstruct the platelet-inhibitory role and activate an enzyme called Paraoxonase 1 that in return defends the oxidation of serum lipids and reduces macrophage formation and treats atherosclerosis [ 82 ].…”

Section: Pharmacological Activities Of Pasmentioning

confidence: 99%

Anticancer, Cardio-Protective and Anti-Inflammatory Potential of Natural-Sources-Derived Phenolic Acids

et al. 2022

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Phenolic acids (PAs) are one of the utmost prevalent classes of plant-derived bioactive chemicals. They have a specific taste and odor, and are found in numerous medicinal and food plants, such as Cynomorium coccineum L., Prunus domestica (L.), and Vitis vinifera L. Their biosynthesis, physical and chemical characteristics and structure–activity relationship are well understood. These phytochemicals and their derivatives exert several bioactivities including but not limited to anticancer, cardioprotective, anti-inflammatory, immune-regulatory and anti-obesity properties. They are strong antioxidants because of hydroxyl groups which play pivotal role in their anticancer, anti-inflammatory and cardioprotective potential. They may play significant role in improving human health owing to anticarcinogenic, anti-arthritis, antihypertensive, anti-stroke, and anti-atherosclerosis activities, as several PAs have demonstrated biological activities against these disease during in vitro and in vivo studies. These PAs exhibited anticancer action by promoting apoptosis, targeting angiogenesis, and reducing abnormal cell growth, while anti-inflammatory activity was attributed to reducing proinflammatory cytokines. Pas exhibited anti-atherosclerotic activity via inhibition of platelets. Moreover, they also reduced cardiovascular complications such as myocardial infarction and stroke by activating Paraoxonase 1. The present review focuses on the plant sources, structure activity relationship, anticancer, anti-inflammatory and cardioprotective actions of PAs that is attributed to modulation of oxidative stress and signal transduction pathways, along with highlighting their mechanism of actions in disease conditions. Further, preclinical and clinical studies must be carried out to evaluate the mechanism of action and drug targets of PAs to understand their therapeutic actions and disease therapy in humans, respectively.

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In vitro Effects of Salicylic Acid on Plasma Paraoxonase 1 Activity

Cited by 3 publications

References 16 publications

Therapeutic Potential of Dietary Phenolic Acids

Therapeutic Potential of Dietary Phenolic Acids

Modulatory Effect of Lifestyle-Related, Environmental and Genetic Factors on Paraoxonase-1 Activity: A Review

Anticancer, Cardio-Protective and Anti-Inflammatory Potential of Natural-Sources-Derived Phenolic Acids

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