IN VITRO EFFECTS OF POLYPHENOLS EXTRACTED FROM THE AROEIRA PLANT (SCHINUS TEREBINTHIFOLIUS RADDI) ON THE GROWTH OF PROSTATE CANCER CELLS (LNCaP, PC-3 AND DU145)

Queires, Luis Carlos Soares; Crépin, Michel; Vacherot, Francis; Taille, A. De La; Rodrigues, Luiz Erlon

doi:10.17267/2317-3386bjmhh.v1i1.114

Cited by 8 publications

(8 citation statements)

References 29 publications

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“…Polyphenols purified from the Brazilian aroeira plant (Schinus terebinthifolius, Raddi), which contain IQ, induced apoptotic and autophagic cell death of an an drogeninsensitive DU145 human prostatic carcinoma cell line [73] .…”

Section: Prostatic Cancermentioning

confidence: 99%

“…A reasonable hypothesis for the IQ antitumor mechanism would be the involvement of signaling pathways mediat ing its modulation of Wnt signaling [74] , which would reaffirm data presented by other studies [67,77] . The Wnt pathway in turn, is related to the p53 pathway (via apoptosis), and published literature has demonstrated its mediation of the apoptosisinducing action of IQ [73] . The induction of apoptosis may be related to caspases, inhibition of ERK phosphorylation, and promotion of JuNK phosphorylation [74] .…”

Section: Antitumor Mechanisms Of Iqmentioning

confidence: 99%

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Review of anticancer mechanisms of isoquercitin

Orfali¹,

Duarte²,

Bonadio³

et al. 2016

WJCO

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This review was based on a literature search of PubMed and Scielo databases using the keywords "quercetin, rutin, isoquercitrin, isoquercitin (IQ), quercetin-3-glucoside, bioavailability, flavonols and favonoids, and cancer" and combinations of all the words. We collected relevant scientific publications from 1990 to 2015 about the absorption, bioavailability, chemoprevention activity, and treatment effects as well as the underlying anticancer mechanisms of isoquercitin. Flavonoids are a group of polyphenolic compounds widely distributed throughout the plant kingdom. The subclass of flavonols receives special attention owing to their health benefits. The main components of this class are quercetin, rutin, and IQ, which is a flavonoid and although mostly found as a glycoside, is an aglycone (lacks a glycoside side chain). This compound presents similar therapeutic profiles to quercetin but with superior bioavailability, resulting in increased efficacy compared to the aglycone form. IQ has therapeutic applications owing to its wide range of pharmacological effects including antioxidant, antiproliferative, anti-inflammatory, anti-hypertensive, and anti-diabetic. The protective effects of IQ in cancer may be due to actions on lipid peroxidation. In addition, the antitumor effect of IQ and its underlying mechanism are related to interactions with Wnt signaling pathway, mixed-lineage protein kinase 3, mitogen-activated protein kinase, apoptotic pathways, as well proinflammatory protein signaling. This review contributed to clarifying the mechanisms of absorption, metabolism, and actions of IQ and isoquercitrin in cancer.

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Section: Prostatic Cancermentioning

confidence: 99%

Section: Antitumor Mechanisms Of Iqmentioning

confidence: 99%

Review of anticancer mechanisms of isoquercitin

Orfali¹,

Duarte²,

Bonadio³

et al. 2016

WJCO

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show abstract

“…3-6 Several scientific studies have brought out the biological importance of this plant, such as its antioxidant, antimicrobial, antiallergic, anticancer, and insecticidal properties. 7-10…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, Anti-inflammatory and Cytotoxic Activity of Schinus terebinthifolia Fruit and Isolation of a New Immunomodulatory Polyphenolic Compound

Alqathama

Abdelhady

Al-Omar

et al. 2022

Pharmacognosy Magazine

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Background: The fruit of Schinus terebinthifolia Raddi is used in ethnomedicine for the treatment of different ailments. Materials and Methods: We studied the phytochemical profile of S. terebinthifolia fruit and evaluated its properties, including its antioxidant, anti-inflammatory, analgesic, cytotoxic and antimicrobial activity. Results: Phytochemical investigation of S. terebinthifolia fruit showed an estimated total phenolic content of 67 mg of gallic acid equivalent (GAE)/g, with respect to gallic acid, while the flavonoid content was 26 mg of quercetin equivalent (QE)/g, in terms of quercetin. Bioassay fractionation of methanolic extract of the fruit resulted in the isolation of a new molecule for the first time from this natural source: 4′,methoxy-6-vinyl-7- O-rhamnosyl-dihydromyricetin or 4′,methoxy-6-vinyl-7- O-rhamnosyl-ampelopsin (Compound 8). Seven other phenolic compounds were isolated, such as (1) gallic acid; (2) afzelin; (3) quercetin 3- O- β-D-glucopyranoside; (4) genistein 7- O- α-l-rhamnopyranoside; (5) ellagic acid; (6) kaempferol and (7) quercetin. The new compound was ascertained using UV, NMR and MS spectra and acid hydrolysis analysis. Significant antioxidant, cytotoxic, anti-inflammatory, analgesic and antimicrobial properties were observed in the alcohol extract, as well as proliferation inhibition in MCF-7 human cancer cell lines. Its activity in elevating glutathione levels in diabetic rats could be due to its anti-inflammatory and immunomodulatory properties. Conclusion: The new compound shows immunomodulatory effects that can be utilized to augment host responses, which is important in both cancer and infectious diseases and thus worth further pharmacological investigation.

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“…This plant has used in traditional medicine as antipyretic, analgesic and in the treatment of urogenital diseases . Several studies have shown that S. terebinthifolius produce pharmacologically important substances, such as anticancer (Bendaoud et al, 2010;Matsuo et al, 2011), antimicrobial (Silva et al, 2010;Pereira et al, 2011), antioxidant (Bendaoud et al, 2010), healing purposes (Estevão et al, 2013) and antiproliferative (Queires et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of Phoma sp. URM 7221: An endophyte from Schinus terebinthifolius Raddi (Anacardiaceae)

Silva¹,

Silvino²,

Bezerra³

et al. 2017

Afr. J. Microbiol. Res.

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The discovery of new metabolites potentially bioactive against pathogenic microorganisms, mainly multidrug resistant, has aroused interest in endophytic fungi. The plant-associated microorganisms have been an important source for development of new compounds of biotechnological interest. This study aimed to investigate the antibacterial capacity of the endophytic fungus, Phoma sp. URM 7221 isolated from the medicinal plant Schinus terebinthifolius against human-pathogenic bacteria. An endophyte was isolated from S. terebinthifolius leaves. Phoma herbarum URM7221 was characterized morphologically and on the basis of ITS rDNA sequence. Primary antimicrobial activity was evaluated using the agar diffusion method and fermentation in liquid medium. Six different solvents were used to extract the active metabolites from fungal biomass and metabolic liquid. An antimicrobial activity test from the extract was carried out using a disk diffusion method with the endophytic extract containing the best antibacterial activity. Two tests were performed: Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Partially purified secondary metabolite extracts were analysed by thin layer chromatography (TLC). Liquid metabolically bioactive compounds extracted with petroleum ether revealed a MIC of 25 and 500 μg.mL −1 against S. aureus and MRSA, respectively. Ether and methanol extracts were assessed by chemical analyses and contained phenolic compounds, triterpenes, steroids, reducing sugars, mono-and sesquiterpenes. The thin layer chromatography assay showed the activity of different antimicrobial compounds produced by Phoma sp. URM7221. This endophyte (URM7221) could be efficiently used for production of bioactive metabolites against pathogenic microorganisms, with significant biotechnological potential.

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IN VITRO EFFECTS OF POLYPHENOLS EXTRACTED FROM THE AROEIRA PLANT (SCHINUS TEREBINTHIFOLIUS RADDI) ON THE GROWTH OF PROSTATE CANCER CELLS (LNCaP, PC-3 AND DU145)

Cited by 8 publications

References 29 publications

Review of anticancer mechanisms of isoquercitin

Review of anticancer mechanisms of isoquercitin

Antioxidant, Anti-inflammatory and Cytotoxic Activity of Schinus terebinthifolia Fruit and Isolation of a New Immunomodulatory Polyphenolic Compound

Antimicrobial activity of Phoma sp. URM 7221: An endophyte from Schinus terebinthifolius Raddi (Anacardiaceae)

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