In vitro effects of peroxisome proliferator–activated receptor-γ ligands on gene expression in lipopolysaccharide-induced endometrial and endometriotic stromal cells

Sharma, Indu; Dhawan, Veena; Saha, S.; Dhaliwal, Lakhbir Kaur

doi:10.1016/j.fertnstert.2010.09.008

Cited by 12 publications

(7 citation statements)

References 24 publications

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“…It has been suggested that there is a direct interaction between PGs and PPARs, because PPAR response element was identified in the PTGS2 gene promoter [59] and the activation of PPARs affected PTGS2 expression in various cell or tissue types including human [60] and bovine endometrial cells [48,61], WISH cells line and primary amnion cells [62]. The administration of different PPARb agonists to the PTGS2 deficient mice restored reduced implantation rates what indicates a direct interaction between these pathways [63].…”

Section: Interactions Between Ppars and Prostaglandins (Pgs)mentioning

confidence: 99%

Peroxisome proliferator-activated receptors in the regulation of female reproductive functions

Bogacka

Kurzyńska

Bogacki

et al. 2015

Folia Histochem Cytobiol.

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Peroxisome proliferator-activated receptors (PPARs) belong to a ligand-dependent nuclear receptor family. In the past decade, numerous studies have revealed the presence and significance of PPARs in the reproductive system. PPARs are expressed at different levels of hypothalamic-pituitary-gonadal (HPG) axis. They are also present in the uterus as well as in the placenta and embryonic tissues of different species. PPARs significance has been reported during the estrous/menstrual cycle and pregnancy with the gamma isoform studied most frequently. Several studies indicate that PPARs regulate proliferation of ovarian cells, tissue remodeling and steroidogenesis. In the endometrium, PPARs are engaged in the regulation of prostaglandins, steroids and cytokines synthesis. The role of PPARs in the trophoblast differentiation, maturation and invasion as well as in the embryo development has also been demonstrated. In this review, we summarize current findings concerning the role of PPARs in the regulation of reproductive functions at different levels of the HPG axis during various physiological statuses of females. In addition, the role of PPARs in the modulation of uterine functions as well as the placenta and embryo development has also been discussed.

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Section: Interactions Between Ppars and Prostaglandins (Pgs)mentioning

confidence: 99%

Peroxisome proliferator-activated receptors in the regulation of female reproductive functions

Bogacka

Kurzyńska

Bogacki

et al. 2015

Folia Histochem Cytobiol.

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“…Glitazone can target Il-6 to decrease the activity of the STAT3 pathway [73,74]. Moreover, TZDs can diminish the expression of numerous inflammatory factors, and TZDs could be used as treatment for pain management in endometriosis [44,75,76].…”

Section: Inflammationmentioning

confidence: 99%

“…Several animal studies have shown that the use of PPARγ agonists lead to the prevention of the development of endometriotic-like lesions [21,[41][42][43]45,77] (Table 1). TZDs downregulate the proliferation of endothelial cells and lead to the reduction of vasculature lesions by inhibiting VEGF expression [44,76,116,117]. The stimulation of PPARγ expression is associated with the reduction of AT1R proteins in endometriotic lesions leading to a decrease in the density of CD31-positive micro-vessels and to the reduction of immune cells [78].…”

Section: Angiogenesismentioning

confidence: 99%

PPARγ Agonists: Emergent Therapy in Endometriosis

Vallée

Blanche

et al. 2021

Pharmaceuticals

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Endometriosis is one of the major gynecological diseases of reproductive-age women. This disease is characterized by the presence of glands and stroma outside the uterine cavity. Several studies have shown the major role of inflammation, angiogenesis, adhesion and invasion, and apoptosis in endometriotic lesions. Nevertheless, the mechanisms underlying endometriotic mechanisms still remain unclear and therapies are not currently efficient. The introduction of new agents can be effective by improving the condition of patients. PPARγ ligands can directly modulate these pathways in endometriosis. However, data in humans remain low. Thus, the purpose of this review is to summarize the potential actions of PPARγ agonists in endometriosis by acting on inflammation, angiogenesis, invasion, adhesion, and apoptosis.

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“…Тиазолидиндионите са клас антидиабетни лекарства, които инхибират експресията на различни възпалителни молекули при хронични възпалителни заболявания и могат да бъдат използвани за лечение на болка, свързана с ендометриоза (93,94). Лечението с розиглитазон инхибира растежа на ендометриозните лезии, клетъчната пролиферация и васкуларизацията и усилва апоптозата при експериментална ендометриоза в сравнение с контролите (95).…”

Section: другиunclassified

Endometriosis - Review Of Current Therapeutic Aproaches For Disease Control

Spasova

Karamisheva

Staneva

et al. 2019

ahp

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UMBALSM "Pirogov" РЕЗЮМЕ Ендометриозата е хронично естроген-зависимо заболяване, което се характеризира с развитие на ендометриална тъкан извън маточната кухина. В световен мащаб засяга около 10% от жените. Заболяването може да причини дисменорея, хронична тазова болка, диспареуния и инфертилитет. Медикаментозното лечение играе ключова роля в контрола на заболяването. В повечето случаи е наложително лекарствената терапия да бъде комбинирана с хирургична, за да бъде постигнато пълно излекуване. Подходът при избор на подходящо медикаментозно лечение трябва да бъде индивидуализиран, като бъде съобразен с тежестта на ендометриозата, ефикасността на лекарството, страничните му ефекти, желанието на пациентката, възрастта ѝ и репродуктивните ѝ планове. Голяма част от използваните днес лекарства за лечение на ендометриоза целят потискане на овариалната функция. Най-често прилаганите и показващи най-добри резултати са комбинираните орални контрацептиви, аналозите на гонадотропин-освобождаващия хормон и прогестините. Освен тези утвърдени терапии, съвременното лечение включва и нови хормонално и нехормонално-базирани терапевтични подходи, които модулират различни патогенетични механизми. В този обзор ще бъдат разгледани настоящите терапевтични опции-както класическите, така и по-новите, все още неодобрени медикаменти за лечение на ендометриоза.

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In vitro effects of peroxisome proliferator–activated receptor-γ ligands on gene expression in lipopolysaccharide-induced endometrial and endometriotic stromal cells

Cited by 12 publications

References 24 publications

Peroxisome proliferator-activated receptors in the regulation of female reproductive functions

Peroxisome proliferator-activated receptors in the regulation of female reproductive functions

PPARγ Agonists: Emergent Therapy in Endometriosis

Endometriosis - Review Of Current Therapeutic Aproaches For Disease Control

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