1984
DOI: 10.1128/iai.46.2.552-558.1984
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In vitro effects of natural killer cells against Paracoccidioides brasiliensis yeast phase

Abstract: Recently, data have been reported suggesting natural killer (NK) cells may function in natural resistance against a fungus, Cryptococcus neoformans. The primary objective of this study was to examine the reactivity of murine splenic cells against another fungus, Paracoccidioides brasiliensis. Levels of NK activity in effector cell pools were varied by: (i) removing nylon wool-adherent cells, (ii) fractionating splenic cells on Percoll discontinuous gradients, (iii) using old and young effector cell donor mice,… Show more

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Cited by 64 publications
(24 citation statements)
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References 28 publications
(29 reference statements)
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“…There is evidence for at least four different mechanisms by which NK cells can augment resistance to infection. These include direct killing in vitro of paracocci (14), Cryptococcus species (12), Toxoplasma species (11), Trypanosoma cruzi (10), Salmonella species (8,27), and Eschenichia coli (8) or direct killing in conjunction with antibody by an antibody-dependent cell-mediated cytotoxicity for Salmonella species, meningococci, and Shigella species (23,25,27). NK cells can apparently also lyse mammalian cells harboring bacteria, as has been described for Legionella and Shigella species (3,18,25).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…There is evidence for at least four different mechanisms by which NK cells can augment resistance to infection. These include direct killing in vitro of paracocci (14), Cryptococcus species (12), Toxoplasma species (11), Trypanosoma cruzi (10), Salmonella species (8,27), and Eschenichia coli (8) or direct killing in conjunction with antibody by an antibody-dependent cell-mediated cytotoxicity for Salmonella species, meningococci, and Shigella species (23,25,27). NK cells can apparently also lyse mammalian cells harboring bacteria, as has been described for Legionella and Shigella species (3,18,25).…”
Section: Discussionmentioning
confidence: 99%
“…There are a number of reports in the literature which suggest a role for natural killer (NK) cells in host defense against bacteria (3,8,23,25,38), fungi (12,14,26), and parasites (10,11). We have considered the hypothesis that the vaccine-induced protection against a virulent Salmonella strain at 3 days postvaccination may be mediated by NK cells.…”
mentioning
confidence: 99%
“…Murine and human NK cells can bind and inhibit growth of fungi such as Cyptococcus neoformans, Paracoccidioides brasiliensis, and Coccidioides immitzi (1044)(1045)(1046). There is some evidence that NK cells play a role in controlling cryptococcal infection.…”
Section: B Nk Cells In Bacterial and Parasitic Infectionmentioning
confidence: 99%
“…Mammalian NK cells have also been shown to bind to and lyse malarial sporozoites [6,7], Toxoplasma [8][9][10], Leishmania [11,12] and trypanosomes [13,14]. Various yeast and fungi [15][16][17][18][19][20][21] interact with NK cells to alter their function either indirectly (lysate blocking of cytotoxicity), or directly by cell contact. The Toxoplasma gondii model [22][23][24] is particularly relevant for studies which indicate a role of NK cells in anti-parasite immunity.…”
Section: Introductionmentioning
confidence: 99%