1986
DOI: 10.1210/jcem-63-3-725
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In Vitro Effects of Human Prolactin and Oxytocin on Sulfatase Activity in Isolated Human Decidual Cells∗

Abstract: Homogeneous preparations of decidual cells were obtained from term decidual tissue adherent to fetal membranes by using a slightly modified version of a technique developed for the isolation of decidual cells from first and second trimester decidua. The effects of human PRL (hPRL) and oxytocin on the kinetics of the hydrolysis of estrone sulfate were determined in decidual cells prepared from tissue obtained before and after the onset of labor. In addition, sulfatase activity in decidual cells isolated from te… Show more

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Cited by 10 publications
(2 citation statements)
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“…Decidual cells were isolated from third-trimester placentas as described by Braverman and Gurpide 22 . Fetal membranes were obtained from non-laboring women undergoing repeat, term, Cesarean deliveries following uncomplicated pregnancies.…”
Section: Tissues and Cell Isolationmentioning
confidence: 99%
“…Decidual cells were isolated from third-trimester placentas as described by Braverman and Gurpide 22 . Fetal membranes were obtained from non-laboring women undergoing repeat, term, Cesarean deliveries following uncomplicated pregnancies.…”
Section: Tissues and Cell Isolationmentioning
confidence: 99%
“…Because the K m value of sulfatase is much greater than that of 3/3-HSD and aromatase, it has been suggested by Gibb and Lavoie (253) that at low steroid concentrations the sulfatase would become ratelimiting in the synthesis of estrogen from DHAS, while only at micromolar concentrations of DHAS would aromatase become rate-limiting. Although the regulation of sulfatase is unknown, PRL and oxytocin stimulated enzyme activity in decidual cells isolated before the onset of human labor (254). Mitchell etal.…”
Section: Enzymes For Estrogen Biosynthesismentioning
confidence: 99%