In Vitro Effects of Colchicine on Human Erythrocyte Membranes: An ESR Study

β-Phenylethylamines and the isoquinoline alkaloids

“…Elimination of the oxide bridge from 209 yielded 210a, which was hydrolysed and acetylated to colchicine 210b. 395 The pharmacological properties and physiological effects of colchicine, [396][397][398][399][400][401][402][403][404] of 2-O-demethylcolchicine, 401 of 3-O-demethylcolchicine, 401 of isocolchicine, 398 of colchiceine 398 and of colchamine 405 have been studied. In a new synthesis of the erythrinane system the imide 212 has been cyclised in one process, by trifluoroacetic anhydride and triethylamine, followed by boron trifluoride, to 213 as a single isomer in 83% yield.…”