In vitro effects of cholecystokinin fragments on human gallbladders

Schneider, Holger; Sänger, P; Hanisch, E.

doi:10.1016/s0168-8278(97)80115-8

Cited by 38 publications

(4 citation statements)

References 22 publications

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“…Several genes have been associated with gallstone disease 61. Identified so far have been: the apolipoproteins E ( APOE ) and B ( APOB ),62 cholesterol ester transporting protein ( CETP ), cholesterol 7 α-hydroxylase,63 cholecystokinin receptor A ( CCKAR ),64 the LDL receptor ( LDLR )65 and the CETP 66. Genome-wide association analysis has revealed that variants for the hepatic cholesterol secretion ( ABCG8 19H and ABCB4 ) represent a susceptibility factor for human gallstones 67,68.…”

Section: Gallstone Diseasementioning

confidence: 99%

Epidemiology of Gallbladder Disease: Cholelithiasis and Cancer

Stinton¹,

Shaffer²

2012

Gut Liver

983

783

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Diseases of the gallbladder are common and costly. The best epidemiological screening method to accurately determine point prevalence of gallstone disease is ultrasonography. Many risk factors for cholesterol gallstone formation are not modifiable such as ethnic background, increasing age, female gender and family history or genetics. Conversely, the modifiable risks for cholesterol gallstones are obesity, rapid weight loss and a sedentary lifestyle. The rising epidemic of obesity and the metabolic syndrome predicts an escalation of cholesterol gallstone frequency. Risk factors for biliary sludge include pregnancy, drugs like ceftiaxone, octreotide and thiazide diuretics, and total parenteral nutrition or fasting. Diseases like cirrhosis, chronic hemolysis and ileal Crohn's disease are risk factors for black pigment stones. Gallstone disease in childhood, once considered rare, has become increasingly recognized with similar risk factors as those in adults, particularly obesity. Gallbladder cancer is uncommon in developed countries. In the U.S., it accounts for only ~ 5,000 cases per year. Elsewhere, high incidence rates occur in North and South American Indians. Other than ethnicity and female gender, additional risk factors for gallbladder cancer include cholelithiasis, advancing age, chronic inflammatory conditions affecting the gallbladder, congenital biliary abnormalities, and diagnostic confusion over gallbladder polyps.

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Section: Gallstone Diseasementioning

confidence: 99%

Epidemiology of Gallbladder Disease: Cholelithiasis and Cancer

Stinton¹,

Shaffer²

2012

Gut Liver

983

783

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“…This patient also had cholelithiasis raising the possibility that the association between cholelithiasis and obesity may be related to CCK receptor dysfunction 58,59…”

Section: Malfunctioning Of Cholecystokinin Receptor Is Associated Witmentioning

confidence: 97%

Vagal Control of Satiety and Hormonal Regulation of Appetite

Owyang¹,

Heldsinger²

2011

J Neurogastroenterol Motil

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The paradigm for the control of feeding behavior has changed significantly. In this review, we present evidence that the separation of function in which cholecystokinin (CCK) controls short-term food intake and leptin regulate long-term eating behavior and body weight become less clear. In addition to the hypothalamus, the vagus nerve is critically involved in the control of feeding by transmitting signals arising from the upper gut to the nucleus of the solitary tract. Among the peripheral mediators, CCK is the key peptide involved in generating the satiety signal via the vagus. Leptin receptors have also been identified in the vagus nerve. Studies in the rodents clearly indicate that leptin and CCK interact synergistically to induce short-term inhibition of food intake and long-term reduction of body weight. The synergistic interaction between vagal CCK-A receptor and leptin is mediated by the phosphorylation of signal transducer and activator of transcription3 (STAT3), which in turn, activates closure of K+ channels, leading to membrane depolarization and neuronal firing. This involves the interaction between CCK/SRC/phosphoinositide 3-kinase cascades and leptin/Janus kinase-2/phosphoinositide 3-kinase/STAT3 signaling pathways. It is conceivable that malfunctioning of these signaling molecules may result in eating disorders.

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“…Several genes have been associated with the development of human gallstone disease [57]. Candidate genes tested in human cohorts include for example the apolipoproteins E (APOE) [58] and B (APOB) [59,60], cholesterol 7 α-hydroxylase [61,62], cholecystokinin receptor A (CCKAR) [63], the low density lipoprotein receptor related protein-associated protein (LRPAP1) [64] and the cholesterol ester transporting protein (CETP) [65]. Finally, genome-wide association analyses and functional studies have identified the p. D19H variant of the hepatic cholesterol hemitransporter (ABCG8) associated with susceptibility for human gallstones [55,66,67].…”

Section: Potential Susceptibility Genes For Gallbladder Cancermentioning

confidence: 99%

Modifiable Factors and Genetic Predisposition Associated with Gallbladder Cancer. A Concise Review

Liebe

Milkiewicz

Krawczyk

et al. 2015

JGLD

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Gallbladder cancer (GbCa) is the most frequent malignancy of the biliary tract. It is also the 6th most common gastrointestinal tumor. It is associated with very high lethality, mainly due to the lack of symptoms up to a very late and thus incurable state. As many as 80% of patients are diagnosed at very late stages of disease, which allow only palliative therapy. As a result, most of the patients with GbCa will die within 6 months of the diagnosis, hence the average 5-year survival does not exceed 5%. Currently, surgical resection represents the only curative option in GbCa, but this approach is feasible only at an early stage of the disease. Other oncologic therapies are of limited use. The incidence of GbCa is remarkably increased in certain populations such as Native North Americans, South Indian females and, in Europe, in the Polish population. It is not clear to date if these enhanced risk populations are the result of common environmental exposure or of shared genetic risk factors. In this review we provide an overview of the state-of-art in GbCa research with the focus on the current knowledge concerning genetic and environmental triggers of this tumor.

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In vitro effects of cholecystokinin fragments on human gallbladders

Cited by 38 publications

References 22 publications

Epidemiology of Gallbladder Disease: Cholelithiasis and Cancer

Epidemiology of Gallbladder Disease: Cholelithiasis and Cancer

Vagal Control of Satiety and Hormonal Regulation of Appetite

Modifiable Factors and Genetic Predisposition Associated with Gallbladder Cancer. A Concise Review

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