In vitro effects of a flavonoid-rich extract on LDL oxidation

Viana, Marta; Barbas, Coral; Bonet, Bartolomé; Bonet, M V; Castro, Mario; Fraile, M. V.; Herrera, Emílio

doi:10.1016/0021-9150(95)05763-3

Cited by 108 publications

(57 citation statements)

References 29 publications

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“…As a result, flavonoids and ascorbate were both found to restore a-toc radical or to delay the consump tion of a-toc (Tables 2 and 3). Our results on the inter action between a-toc and flavonoids are supported by a report from Viana et al (28), using flavonoid-rich ex tracts. The cooperative effects of flavonoids and ascor bate have been recognized by Mathiesen et al (29) and Skaper et al (30), who described that ascorbate-pro tected flavonoids from oxidation.…”

Section: Discussionsupporting

confidence: 81%

Antioxidant Ability of Various Flavonoids against DPPH Radicals and LDL Oxidation.

Hirano

Sasamoto

Matsumoto

et al. 2001

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

240

121

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SummaryFlavonoids, a group of polyphenolic compounds, exist naturally and serve as antioxidants in vegetables, fruits, and so on. The inhibition of low density lipoprotein (LDL) oxidation may be an effective way to prevent or delay the progression of atherosclerosis. In the present study, we analyzed the radical scavenging capacity of 10 flavonoids (catechin,, myricetin, quercetiji, apigenin, kaempferol, and luteolin) toward 1,1-Biphenyl-2 picryl-hydrazyl [DPPH]. After 20min of incubation, EGCg was the most effective DPPH radi cal scavenger, luteolin being the least active of this flavonoid group. The mutual antioxidant effect of flavonoids with a-tocopherol (a-toc) on LDL oxidizability was investigated by using the lipophilic azo radical initiator 2 ,2'-azobis(4-methoxy-2,4-dimethylvaleronitrile) . An inhibitory effect of flavonoids on LDL oxidation was observed in the order of luteolin>ECg>EC>quercetin>catechin>EGCg>EGC>myricetin>kaempferol> apigenin. The shortened lag time induced by higher doses of a-toc (6mg/100mL) was re stored by flavonoids. These results suggest that 1) radical trapping effects of flavonoids differ according to their structure, and 2) flavonoids act as hydrogen donors to a-toc radical; fur thermore, by interaction with a-toc, they have a greater potential to delay the oxidation of LDL.

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Section: Discussionsupporting

confidence: 81%

Antioxidant Ability of Various Flavonoids against DPPH Radicals and LDL Oxidation.

Hirano

Sasamoto

Matsumoto

et al. 2001

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

240

121

View full text Add to dashboard Cite

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“…Some studies have shown that antioxidants such as tocopherol inhibit the development of atherosclerotic lesions in rabbits fed atherogenic diets (24). It has also been hypothesized that some antioxidants can prevent atherosclerosis by protecting LDL from oxidation (25) and an example is shown that their consumption is associated with a hypocholesterolemic effect (26). Yoshizumi et al (2001) also demonstrated that natural polyphenolic compound quercetin inhibited vascular smooth muscle cell hypertrophy via the inhibition of mitogen-activated protein kinases (27).…”

Section: Discussionmentioning

confidence: 99%

Antioxidative and Hypolipidemic Effects of Barley Leaf Essence in a Rabbit Model of Atherosclerosis

Tseng

et al. 2002

Japanese Journal of Pharmacology

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ABSTRACT-The antioxidative and hypolipidemic effects of barley leaf essence (BL) were investigated in a rabbit model of atherosclerosis. Twenty-four New Zealand White male rabbits were assigned randomly into four dietary groups. The normal group was fed regular rabbit chow and the control group was fed a chow containing 0.5% cholesterol and 10% corn oil. The BL group and the probucol group were fed the same diet as the control group plus 1% (w /w) BL or 1% (w /w) probucol, respectively. The plasma levels of total cholesterol, triacylglycerol, lucigenin-chemiluminescence (CL) and luminol-CL were increased in the control group compared to the normal group; and they were decreased in the BL group and the probucol group compared to the control group. The value of T50 of red blood cell hemolysis and the lag phase of lowdensity lipoprotein oxidation increased in the BL group and in the probucol group compared to the controls. Ninety percent of the intimal surface of the thoracic aorta was covered with atherosclerotic lesions in the control group, but only 60% of the surface was covered in the BL group. This 30% inhibition of hyperlipidemic atherosclerosis by BL was associated with a decrease in plasma lipids and an increase in antioxidative abilities (as measured by T50, lag phase and CL). These results suggest that the antioxidant and hypolipidemic effects of BL could be useful in the prevention of cardiovascular disease in which atherosclerosis is important.

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“…[1][2][3] The protective effect of flavonoids, in particular the subgroup of flavonols, has been attributed to antioxidative activity. [4][5][6] Quercetin, for example, has been shown to inhibit oxidative modification of lowdensity lipoproteins and the development of fatty streaks in animals. 7,8 About half of the flavonol intake in Western populations is derived from black tea.…”

Section: Discussionmentioning

confidence: 99%

Tea Flavonoids May Protect Against Atherosclerosis

Geleijnse¹,

Launer²,

Hofman³

et al. 1999

Arch Intern Med

212

103

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Background: Epidemiological studies have indicated a protective role of dietary flavonoids in cardiovascular disease, but evidence is still conflicting. Tea is the major dietary source for flavonoids in Western populations. We studied the association of tea intake with aortic atherosclerosis in a general population. Methods:The present analysis formed part of the Rotterdam Study, a prospective study of men and women 55 years and older. Dietary intakes were assessed at baseline by a trained dietician who used a semiquantitative food frequency questionnaire. Calcified plaques in the abdominal aorta were radiographically detected after 2 to 3 years of follow-up. Aortic atherosclerosis was classified as "mild," "moderate," or "severe," according to the length of the calcified area (Ͻ1 cm, 1-5 cm, and Ͼ5 cm, respectively). The association of tea intake with severity of aortic atherosclerosis was studied in 3454 subjects who were free of cardiovascular disease at baseline. Data were analyzed by logistic regression, adjusting for age, sex, body mass index (calculated as weight in kilograms divided by the square of height in meters), smoking, education, and intake of alcohol, coffee, vitamin antioxidants, total fat, and total energy.Results: Multivariable analyses showed a significant, inverse association of tea intake with severe aortic atherosclerosis. Odds ratios decreased from 0.54 (95% confidence interval [CI], 0.32-0.92) for drinking 125 to 250 mL (1-2 cups) of tea to 0.31 (CI, 0.16-0.59) for drinking more than 500 mL/d (4 cups per day). The associations were stronger in women than in men. The association of tea intake with mild and moderate atherosclerosis was not statistically significant. Conclusion:This study indicates a protective effect of tea drinking against ischemic heart disease.

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In vitro effects of a flavonoid-rich extract on LDL oxidation

Cited by 108 publications

References 29 publications

Antioxidant Ability of Various Flavonoids against DPPH Radicals and LDL Oxidation.

Antioxidant Ability of Various Flavonoids against DPPH Radicals and LDL Oxidation.

Antioxidative and Hypolipidemic Effects of Barley Leaf Essence in a Rabbit Model of Atherosclerosis

Tea Flavonoids May Protect Against Atherosclerosis

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