1968
DOI: 10.1016/s0009-9120(68)80091-8
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In vitro effect of sodium phenobarbital and diethylnicotinamide (coramine) on the protein binding of bilirubin

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1969
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Cited by 11 publications
(3 citation statements)
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“…The pharmacological properties of phenobarbital and nicethamide, the two substances chosen for induction, have been known for a long time. Antagonistic action of phenobarbital against nicethamide and vice versa was offset on a recipropal basis in the intended way by the dosage used for Group V. There is no evidence that either nicethamide (4, 5 , 17) or phenobarbital (4, 17) will free bilirubin linked to albumin. Prophylactic routine use of the enzyme inductor combination phenobarbital/nicethamide in the manner used in Group V, is therefore recommended as a preferred method to prevent the development of hyperbilirubinemia in premature infants.…”
Section: Discussionmentioning
confidence: 97%
“…The pharmacological properties of phenobarbital and nicethamide, the two substances chosen for induction, have been known for a long time. Antagonistic action of phenobarbital against nicethamide and vice versa was offset on a recipropal basis in the intended way by the dosage used for Group V. There is no evidence that either nicethamide (4, 5 , 17) or phenobarbital (4, 17) will free bilirubin linked to albumin. Prophylactic routine use of the enzyme inductor combination phenobarbital/nicethamide in the manner used in Group V, is therefore recommended as a preferred method to prevent the development of hyperbilirubinemia in premature infants.…”
Section: Discussionmentioning
confidence: 97%
“…Caffeine complexation was shown to reduce the rate of transport in vitro of salicylic acid, ethyl p-hydroxybenzoate, dehydroacetic acid, and aspirin (Bates et al 1970). Caffeine sodium benzoate also decreased in vitro the percent of bilirubin that was protein-bound (Khanna et al 1969). Caffeine was ineffective against the depressant actions of alcohol on motor coordination, but decreased simple auditory and visual reaction times which could in itself lead to a false sense of fitness (Franks et al 1975).…”
Section: Pharmacological Actionsmentioning
confidence: 94%
“…It may be that measurement of the 'free' bilirubin level will eventually prove a better index of the likelihood of brain damage in infants with hyperbilirubinaemia (Odell, Storey, and Rosenberg, 1970). It is already known that phenobarbitone does not act to lower serum bilirubin levels by displacing indirect bilirubin from its binding sites in the blood (Khanna, Harpur, and Stern, 1969).…”
mentioning
confidence: 99%