In vitro effect of hydrocortisone on the attachment and ingestion phases of immunoglobulin G- and complement component 3b-mediated phagocytosis by human neutrophils

Hed, J.

doi:10.1128/iai.38.3.811-816.1982

Cited by 24 publications

(5 citation statements)

References 30 publications

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“…on neutrophil fuction is still uncertain. Plasma cortisol concentration has been previously correlated with a reduction in neutrophil function following prolonged exercise [13] and has also been shown to suppress neutrophil function in vitro [11,30]. However, these studies used concentrations of cortisol~50 times greater than levels reported in human plasma following a prolonged bout of exhaustive exercise.…”

Section: Discussionmentioning

confidence: 99%

Carbohydrate Beverage Ingestion and Neutrophil Degranulation Responses Following Cycling to Fatigue at 75 % V˙O₂ max

Bishop¹,

Blannin²,

Walsh³

et al. 2001

Int J Sports Med

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Carbohydrate (CHO) beverage ingestion appears to influence neutrophil functional responses to prolonged exercise of a fixed duration. The aim of this randomised study was to examine the effect of CHO (5% w/v) beverage ingestion on lipopolysaccharide (LPS)-stimulated neutrophil degranulation responses in nine recreationally active males who cycled at 75% VO2 max until fatigue. On two separate occasions, subjects ingested either placebo (PLA) or CHO beverages before and at 15 min intervals during the exercise. Subjects exercised for 31% longer on the CHO trial compared with the PLA trial (P < 0.05). At fatigue plasma glucose concentration was significantly lower on the PLA trial compared with the CHO trial (P < 0.05). Plasma cortisol concentrations had increased similarly on both trials at this time. A marked neutrophilia was evident at fatigue and throughout the 4 h recovery period, the magnitude of which was similar on both trials. At fatigue LPS-stimulated elastase release per neutrophil had fallen similarly on both trials compared with pre-exercise values (47% and 50% on the PLA and CHO trials, respectively). In conclusion, our results suggest that CHO beverage ingestion has negligible influence on the hormonal, circulating neutrophil and LPS-stimulated neutrophil degranulation responses when exercise is performed to fatigue.

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Section: Discussionmentioning

confidence: 99%

Carbohydrate Beverage Ingestion and Neutrophil Degranulation Responses Following Cycling to Fatigue at 75 % V˙O₂ max

Bishop¹,

Blannin²,

Walsh³

et al. 2001

Int J Sports Med

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“…Strenuous exercise suppresses the function of these phagocytic cells (Raidal et al 2000a,b;Jensen-Waern et al 1999;Wong et al 1990). The observed post exercise suppression of the innate immune system may be mediated through the actions of stress hormones such as cortisol (Forslid and Hed 1982) or a decrease in the plasma concentration of glutamine, an amino acid required for optimal functioning of some leucocytes Newsholme 1983, 1985). Plasma glutamine concentration has been shown to fall following prolonged exercise in man (Robson et al 1999;Rohde et al 1996).…”

Section: Introductionmentioning

confidence: 99%

Prolonged suppression of the innate immune system in the horse following an 80 km endurance race

Robson

Alston

Myburgh

2003

Equine Veterinary Journal

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Summary Reasons for performing study: An increased susceptibility to bacterial and viral infections of the respiratory tract, which results in a loss of performance, has been reported in racehorses. Much research has focused on the influence of high‐intensity exercise of a short duration on immune system function in horses, but scant attention has been given to prolonged endurance exercise as an immune modulator. Objectives: The objective of this study was to evaluate the effect of an 80 km endurance race on the monocyte and neutrophil oxidative burst, serum Cortisol, glutamine and plasma glucose concentrations in 8 endurance‐trained horses (mean ± s.d. age 9.4 ± 2.2 years). Methods: Blood samples were drawn from the horses prior to and following an 80 km ride. Results: Mean time for completion of the 80 km race was 306 ± 40 mins. Immediately post race mean serum Cortisol concentration, blood monocyte and neutrophil counts were higher and blood lymphocyte counts and plasma glucose concentration were lower compared with prerace values (P<0.05). Neutrophil and monocyte oxidative burst activity decreased following the race and had not regained prerace values after 3 days of rest (P<0.05). Conclusions: The present study indicates that long duration exercise in horses has a negative impact on the function of the innate immune system that lasts several days post race. Precise mechanisms instigating the fall in innate immune system function are unclear and multifactorial, but may be attributed, at least in part, to a high serum Cortisol response during very prolonged exercise. Potential clinical relevance: A prolonged bout of exercise results in a long‐term suppression of the innate immune system function in horses which may, in part, account for the observed increase of infectious episodes in horses during training.

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“…On the other hand, post-exertional supression of neutrophil function is related to, among other factors, an increase in blood cortisol concentration (Kraemer et al 2020). In vitro experiments demonstrated that high doses of hydrocortisol decrease the mobilization of complement receptor expression (CR1 and CR3) resulting in reduced phagocytosis and oxidative burst activity (Forslid and Hed 1982). As a consequence, increased blood cortisol concentration, post--excertional neutrophilia is connected to a release of immature cells with limited phagocytic functions from the bone marrow (Robson et al 2003).…”

Section: Discussionmentioning

confidence: 99%

Polish Journal of Veterinary Sciences

Krumrych

Daněk

Markiewicz

et al. 2021

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The aim of this study was to analyze the chemiluminescence (CL) of peripheral blood in clinically healthy horses of different sexes and ages. The tests were carried out on 119 half--breed horses, representing various forms of use (66 recreational horses and 53 sport horses). The test material was peripheral blood, which was collected under resting conditions, i.e. before physical activity related to the use of these animals. In the blood samples, spontaneous and stimulated CL with zymosan and phorbol myristate acetate were determined. It has been found that regular training effort increases the blood's pro-oxidative potential, which was demonstrated by significantly higher (p<0.05) CL values in sport horses compared to recreational animals. Analysis of the results did not show any statistically significant correlation between sex or age of the horses with chemiluminescence values in peripheral blood. The result of the research suggests the need to optimize the results of blood CL measurements, taking into account the number of neutrophils and the concentration of hemoglobin in the blood of tested animals. Analysis of non-optimized blood CL results may lead to premature conclusions.

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In vitro effect of hydrocortisone on the attachment and ingestion phases of immunoglobulin G- and complement component 3b-mediated phagocytosis by human neutrophils

Cited by 24 publications

References 30 publications

Carbohydrate Beverage Ingestion and Neutrophil Degranulation Responses Following Cycling to Fatigue at 75 % V˙O₂ max

Carbohydrate Beverage Ingestion and Neutrophil Degranulation Responses Following Cycling to Fatigue at 75 % V˙O₂ max

Prolonged suppression of the innate immune system in the horse following an 80 km endurance race

Polish Journal of Veterinary Sciences

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In vitro effect of hydrocortisone on the attachment and ingestion phases of immunoglobulin G- and complement component 3b-mediated phagocytosis by human neutrophils

Cited by 24 publications

References 30 publications

Carbohydrate Beverage Ingestion and Neutrophil Degranulation Responses Following Cycling to Fatigue at 75 % V˙O2 max

Carbohydrate Beverage Ingestion and Neutrophil Degranulation Responses Following Cycling to Fatigue at 75 % V˙O2 max

Prolonged suppression of the innate immune system in the horse following an 80 km endurance race

Polish Journal of Veterinary Sciences

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Resources

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Carbohydrate Beverage Ingestion and Neutrophil Degranulation Responses Following Cycling to Fatigue at 75 % V˙O₂ max

Carbohydrate Beverage Ingestion and Neutrophil Degranulation Responses Following Cycling to Fatigue at 75 % V˙O₂ max