In Vitro Effect of Ankaferd Blood Stopper®, a Plant Extract Against Mycobacterium tuberculosis Isolates

Deveci, Aydın; Çoban, Ahmet Yılmaz; Çaycı, Yeliz Tanrıverdi; Acicbe, Ozlem; Fışgın, Nuriye Taşdelen; Akgunes, Alper; Özatlı, Düzgün; Uzun, Meltem; Durupinar, Belma

doi:10.5578/mb.4264

Cited by 16 publications

(14 citation statements)

References 9 publications

(11 reference statements)

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“…Oral/endoscopic ABS administration has already been performed in GI hemorrhages [9,12,13,14,15,16,17,18,19,20,21,22,23]. Moreover, ABS is active against multiresistant bacteria, such as methicillin-resistant Staphylococcus aureus, Enterococcus spp., generic E. coli, Klebsiella spp., Acinetobacter spp., and Pseudomonas spp., as well as fungi such as Aspergillu s spp., Mucor spp., and Candida albicans [4,5,6,7,8]. Our findings in this study further support previous research findings that ABS has antibacterial effects.…”

Section: Discussionsupporting

confidence: 92%

“…Furthermore, as indicated by Akkoç et al, the antibacterial activity of ABS can proceed in extreme environmental conditions such as the potential use of the preparation for the therapy of infectious diseases and preservation of different types of foods from foodborne pathogens or food-spoilage bacteria [5,48]. Our present results support the idea that the antiinfective properties of ABS should be tested in in vivo experiments [4,5,6,7,8]. …”

Section: Discussionsupporting

confidence: 85%

“…Previous studies indicated that ABS might be used as a supportive agent together with antituberculous drugs during debridement of osteomyelitis and lymphadenitis lesions caused by multidrug-resistant Mycobacterium tuberculosis [4]. Oral/endoscopic ABS administration has already been performed in GI hemorrhages [9,12,13,14,15,16,17,18,19,20,21,22,23].…”

Section: Discussionmentioning

confidence: 99%

“…ABS-induced pharmacological modulation of essential erythroid proteins (ankyrin, spectrin, actin) can cause vital erythroid aggregation by acting on fibrinogen gamma [3]. ABS also has pleiotropic effects, particularly in tissue healing, and has significant antiinfective properties [4,5,6,7,8]. The use of ABS in gastrointestinal (GI) system hemorrhages to control bleeding and/or infected GI wounds is also evident [9].…”

Section: Introductionmentioning

confidence: 99%

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Antibacterial Activities of Ankaferd Hemostat (ABS) on Shiga Toxin-Producing Escherichia coli and Other Pathogens Significant in Foodborne Diseases

Koluman¹,

Akar²,

Haznedaroğlu³

2017

Tjh

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Objective:Ankaferd hemostat (Ankaferd Blood Stopper®, ABS)-induced pharmacological modulation of essential erythroid proteins can cause vital erythroid aggregation via acting on fibrinogen gamma. Topical endoscopic ABS application is effective in the controlling of gastrointestinal (GI) system hemorrhages and/or infected GI wounds. Escherichia coli O157:H7, the predominant serotype of enterohemorrhagic E. coli, is a cause of both outbreaks and sporadic cases of hemorrhagic colitis. The aim of this study is to examine the effects of ABS on 6 different Shiga toxigenic E. coli serotypes including O26, O103, O104, O111, O145, and O157 and on other pathogens significant in foodborne diseases, such as Salmonella Typhimurium, Campylobacter jejuni, and Listeria monocytogenes, were also assessed.Materials and Methods:All strains were applied with different amounts of ABS and antimicrobial effect was screened. S. Typhimurium groups were screened for survival using the fluorescence in situ hybridization technique.Results:The relative efficacy of ABS solutions to achieve significant logarithmic reduction in foodborne pathogens E. coli O157:H7 and non-O157 serogroups and other emerging foodborne pathogens is demonstrated in this study. ABS has antibacterial effects.Conclusion:Our present study indicated for the first time that ABS may act against E. coli O157:H7, which is a cause of thrombotic thrombocytopenic purpura, hemolytic-uremic syndrome, and hemorrhagic colitis. The interrelationships between colitis, infection, and hemostasis within the context of ABS application should be further investigated in future studies.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antibacterial Activities of Ankaferd Hemostat (ABS) on Shiga Toxin-Producing Escherichia coli and Other Pathogens Significant in Foodborne Diseases

Koluman¹,

Akar²,

Haznedaroğlu³

2017

Tjh

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“…3 The pleiotropic effects of ABS on vascular endothelium, blood cells, angiogenesis, cellular proliferation, vascular dynamics, and cellular mediators have been investigated. 4–8 The use of ABS in the gastrointestinal (GI) system hemorrhages to control bleeding and/or infected GI wounds is also evident. 9 Controlled clinical trials indicated the safety and efficacy of ABS for the control of clinical bleedings in an extensive variety of settings.…”

Section: Introductionmentioning

confidence: 99%

Growth inhibitory activity of Ankaferd hemostat on primary melanoma cells and cell lines

et al. 2017

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Objective:Ankaferd hemostat is the first topical hemostatic agent about the red blood cell–fibrinogen relations tested in the clinical trials. Ankaferd hemostat consists of standardized plant extracts including Alpinia officinarum, Glycyrrhiza glabra, Thymus vulgaris, Urtica dioica, and Vitis vinifera. The aim of this study was to determine the effect of Ankaferd hemostat on viability of melanoma cell lines.Methods:Dissimilar melanoma cell lines and primary cells were used in this study. These cells were treated with different concentrations of Ankaferd hemostat to assess the impact of different dosages of the drug. All cells treated with different concentrations were incubated for different time intervals. After the data had been obtained, one-tailed T-test was used to determine whether the Ankaferd hemostat would have any significant inhibitory impact on cell growth.Results:We demonstrated in this study that cells treated with Ankaferd hemostat showed a significant decrease in cell viability compared to control groups. The cells showed different resistances against Ankaferd hemostat which depended on the dosage applied and the time treated cells had been incubated. We also demonstrated an inverse relationship between the concentration of the drug and the incubation time on one hand and the viability of the cells on the other hand, that is, increasing the concentration of the drug and the incubation time had a negative impact on cell viability.Conclusion:The findings in our study contribute to our knowledge about the anticancer impact of Ankaferd hemostat on different melanoma cells.

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Alpinia officinarum

Lim¹

2016

Edible Medicinal and Non-Medicinal Plants

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In Vitro Effect of Ankaferd Blood Stopper®, a Plant Extract Against Mycobacterium tuberculosis Isolates

Cited by 16 publications

References 9 publications

Antibacterial Activities of Ankaferd Hemostat (ABS) on Shiga Toxin-Producing Escherichia coli and Other Pathogens Significant in Foodborne Diseases

Antibacterial Activities of Ankaferd Hemostat (ABS) on Shiga Toxin-Producing Escherichia coli and Other Pathogens Significant in Foodborne Diseases

Growth inhibitory activity of Ankaferd hemostat on primary melanoma cells and cell lines

Alpinia officinarum

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