In vitro drug-drug interactions in rat liver between oxycodone and commonly co-consumed drugs
Weilong Gu,
Rachel Tyndale
Abstract:Background and Purpose: The co-use of opioids and other drugs is
prevalent, both in a clinical setting and during opioid misuse. We
investigated whether drug-drug interactions occur between oxycodone and
xylazine, diazepam, etizolam, and methamphetamine using rat liver
microsomes. Experimental Approach: Michaelis–Menten parameters (Km,
Vmax), and intrinsic clearance (CLint) of oxymorphone and noroxycodone
formation were determined. Inhibition Kis for xylazine, diazepam, and
etizolam were assessed. Inhibition o… Show more
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