In Vitro Dose Response to Different GPIIb/IIIa-Antagonists: Inter-Laboratory Comparison of Various Platelet Function Tests

Harder, Sebastian; Klinkhardt, Ute; Graff, Jochen; Westrup, Dagmar; Kirchmaier, C. M.; Glusa, Erika; Mascelli, Mary Ann; Marciniak, Stanley J.; Just, Armin; Lösche, Wolfgang; Breddin, H. K.

doi:10.1016/s0049-3848(01)00223-7

Cited by 29 publications

(22 citation statements)

References 31 publications

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“…Platelet function measured by the PFA-100 is dependent on the level of von Willebrand Factor in plasma [12][13][14][15] and is responsive to inhibition of cyclo-oxygenase and various platelet receptors [16,17].…”

Section: Study Populationmentioning

confidence: 99%

Plasma salicylate level and aspirin resistance in survivors of myocardial infarction

Ahmed

Meek

Davies

2009

J Thromb Thrombolysis

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To investigate the effect of aspirin on the platelets of survivors of myocardial infarction we correlated plasma salicylate level with platelet reactivity in ten patients and ten normal controls. The patients and controls were tested at the end of 2 week periods on 75, 150 and 300 mg aspirin daily by mouth. Platelet reactivity was measured, under high shear stress conditions, using cartridges containing adrenaline and adenosine diphosphate in a PFA-100 platelet function analyser. The time taken by the developing platelet aggregate to close an aperture in the collagen membrane of the cartridge, the closure time, was taken as an index of platelet reactivity. There was no difference in baseline haematocrit, platelet count or plasma vWF antigen level between the groups. There was a dose-dependent increase in closure time of the adrenaline containing cartridge in the controls (P < 0.001), but not in the patients (P = 0.08), compatible with a reduced anti-platelet effect of aspirin in the patients. Furthermore, plasma salicylate level was higher in the patient group (P < 0.05).

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Section: Study Populationmentioning

confidence: 99%

Plasma salicylate level and aspirin resistance in survivors of myocardial infarction

Ahmed

Meek

Davies

2009

J Thromb Thrombolysis

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“…The selected concentrations of GPIIb/IIIa inhibitors we used were based on previous reports [20][21][22][23][24][25] and on our prestudy experiments (data not shown). For the determination of the CADP-CT, lepirudin anticoagulated whole blood (980 L) was incubated with acetylsalicylic acid (10 L; final concentration: 50 mg/L) and either eptifibatide (10 L; final concentration: 200, 400, 800, and 1600 ng/mL), abciximab (10 L; final concentration: 1000, 1500, and 3000 ng/mL), or tirofiban (10 L; final concentration: 20, 40, and 80 ng/mL) for 3 minutes at room temperature.…”

Section: Aspirin and Gpiib/iiia Inhibitors: In Vitro Incubation Expermentioning

confidence: 99%

Desmopressin antagonizes the in vitro platelet dysfunction induced by GPIIb/IIIa inhibitors and aspirin

Reiter

Mayr

Blazicek

et al. 2003

Blood

130

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“…However, antithrombotic agents, such as aspirin, recently developed drugs like the thienopyridins (ticlopidine, clopidogrel) and antagonists (abciximab, eptifibatide) of the glycoprotein IIb/IIIa (Harder et al, 2001) and thromboxane A 2 synthetase, have side effects including gastrointestinal symptoms and hemorrhage (Johansen, 2006).…”

Section: Introductionmentioning

confidence: 99%

Blockade of glycoprotein IIb/IIIa mediates the antithrombotic activity of butanol fraction of Actinostemma lobatum Maxim

Kim

Lee

et al. 2008

Journal of Ethnopharmacology

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In Vitro Dose Response to Different GPIIb/IIIa-Antagonists: Inter-Laboratory Comparison of Various Platelet Function Tests

Cited by 29 publications

References 31 publications

Plasma salicylate level and aspirin resistance in survivors of myocardial infarction

Plasma salicylate level and aspirin resistance in survivors of myocardial infarction

Desmopressin antagonizes the in vitro platelet dysfunction induced by GPIIb/IIIa inhibitors and aspirin

Blockade of glycoprotein IIb/IIIa mediates the antithrombotic activity of butanol fraction of Actinostemma lobatum Maxim

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