In vitro DNA Packaging of PRD1: A Common Mechanism for Internal-membrane Viruses

Strömsten, Nelli J.; Bamford, Dennis H.; Bamford, Jaana K. H.

doi:10.1016/j.jmb.2005.03.002

Cited by 75 publications

(90 citation statements)

References 90 publications

(79 reference statements)

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“…In alphaspaerolipoviruses and the related proviruses HalaPauP1 and HaloLacP1, the ATPase gene is separated by six genes from the sequentially arranged MCP genes and transcribed in the opposite direction. The ATPases of members of the Sphaerolipoviridae in addition to the classical Walker A and B motifs carry a signature motif common to all icosahedral dsDNA viruses with an internal membrane [18,53] and initially identified in the packaging ATPase P9 of PRD1 (Online Resource 2, Fig. 3) [53], providing additional phylogenetic link between the Sphaerolipoviridae and the PRD1/adenovirus lineage.…”

Section: Phylogenetic Relationships Within the Sphaerolipoviridaementioning

confidence: 99%

Gammasphaerolipovirus, a newly proposed bacteriophage genus, unifies viruses of halophilic archaea and thermophilic bacteria within the novel family Sphaerolipoviridae

et al. 2014

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A new family of viruses named Sphaerolipoviridae has been proposed recently. It comprises icosahedral, tailless haloarchaeal viruses with an internal lipid membrane located between the protein capsid and the dsDNA genome. The proposed family Sphaerolipoviridae was divided into two genera: Alphasphaerolipovirus, including Haloarcula hispanica viruses SH1, PH1 and HHIV-2, and Betasphaerolipovirus, including Natrinema virus SNJ1. Here, we propose to expand the family Sphaerolipoviridae to include a group of bacteriophages infecting extreme thermophilic Thermus thermophilus and sharing a number of structural and genomic properties with archaeal sphaerolipoviruses. This new group comprises two members, lytic phage P23-77 and temperate phage IN93, as well as putative members P23-72 and P23-65H. In addition, several related proviruses have been discovered as integrated elements in bacterial genomes of the families Thermus and Meiothermus. Morphology of the virus particles and the overall capsid architecture of these bacteriophages resembles that of archaeal members of the Sphaerolipoviridae, including an unusual capsid arrangement in a T = 28 dextro lattice. Alpha-and betasphaerolipoviruses share with P23-77-like bacteriophages a conserved block of core genes that encode a putative genome-packaging ATPase and the two major capsid proteins (MCPs). The recently determined X-ray structure of the small and large MCPs of P23-77 revealed a single beta-barrel (jelly-roll) fold that is superimposable with the cryo-EM density maps of the SH1 capsomers. Given the common features of these viruses, we propose to include the so far unclassified P23-77-like bacteriophages into a new genus, ''Gammasphaerolipovirus'', within the family Sphaerolipoviridae.

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Section: Phylogenetic Relationships Within the Sphaerolipoviridaementioning

confidence: 99%

Gammasphaerolipovirus, a newly proposed bacteriophage genus, unifies viruses of halophilic archaea and thermophilic bacteria within the novel family Sphaerolipoviridae

et al. 2014

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“…A recent structural analysis revealed that the MCP and the penton protein of PM2 have the same general topology as the corresponding proteins of tectivirus PRD1 (2). In addi-tion, the two viruses encode homologous genome-packaging ATPases (262).…”

Section: Corticoviridaementioning

confidence: 99%

“…Interestingly, the major capsid proteins of tectivirus PRD1, corticovirus PM2, and archaeal STIV were found to possess the same structural fold (1, 2, 17, 131, 145). In addition, the three viruses encode homologous genome-packaging enzymes (262).…”

Section: Vol 75 2011 Genomics Of Prokaryotic Viruses 623mentioning

confidence: 99%

Genomics of Bacterial and Archaeal Viruses: Dynamics within the Prokaryotic Virosphere

Krupovìč

Prangishvili

Hendrix

et al. 2011

Microbiol Mol Biol Rev

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216

176

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SUMMARY Prokaryotes, bacteria and archaea, are the most abundant cellular organisms among those sharing the planet Earth with human beings (among others). However, numerous ecological studies have revealed that it is actually prokaryotic viruses that predominate on our planet and outnumber their hosts by at least an order of magnitude. An understanding of how this viral domain is organized and what are the mechanisms governing its evolution is therefore of great interest and importance. The vast majority of characterized prokaryotic viruses belong to the order Caudovirales, double-stranded DNA (dsDNA) bacteriophages with tails. Consequently, these viruses have been studied (and reviewed) extensively from both genomic and functional perspectives. However, albeit numerous, tailed phages represent only a minor fraction of the prokaryotic virus diversity. Therefore, the knowledge which has been generated for this viral system does not offer a comprehensive view of the prokaryotic virosphere. In this review, we discuss all families of bacterial and archaeal viruses that contain more than one characterized member and for which evolutionary conclusions can be attempted by use of comparative genomic analysis. We focus on the molecular mechanisms of their genome evolution as well as on the relationships between different viral groups and plasmids. It becomes clear that evolutionary mechanisms shaping the genomes of prokaryotic viruses vary between different families and depend on the type of the nucleic acid, characteristics of the virion structure, as well as the mode of the life cycle. We also point out that horizontal gene transfer is not equally prevalent in different virus families and is not uniformly unrestricted for diverse viral functions.

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“…A reliable model was generated for the putative ATPase B204 (see Fig. S2 and Tables S2 and S3 in the supplemental material) as a P-loop ATPase that would belong to a dsDNA virusspecific clade that has been predicted from sequence analysis (23,36,62). It is predicted to have a fold similar to that of the Pseudomonas aeruginosa FstK DNA translocase (39).…”

Section: Stiv2 Isolation and Persistence Of Infectionmentioning

confidence: 99%

Familial Relationships in Hyperthermo- and Acidophilic Archaeal Viruses

Happonen

Redder

Peng

et al. 2010

J Virol

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Archaea often live in extreme, harsh environments such as acidic hot springs and hypersaline waters. To date, only two icosahedrally symmetric, membrane-containing archaeal viruses, SH1 and Sulfolobus turreted icosahedral virus (STIV), have been described in detail. We report the sequence and three-dimensional structure of a third such virus isolated from a hyperthermoacidophilic crenarchaeon, Sulfolobus strain G4ST-2. Characterization of this new isolate revealed it to be similar to STIV on the levels of genome and structural organization. The genome organization indicates that these two viruses have diverged from a common ancestor. Interestingly, the prominent surface turrets of the two viruses are strikingly different. By sequencing and mass spectrometry, we mapped several large insertions and deletions in the known structural proteins that could account for these differences and showed that both viruses can infect the same host. A combination of genomic and proteomic analyses revealed important new insights into the structural organization of these viruses and added to our limited knowledge of archaeal virus life cycles and host-cell interactions.

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In vitro DNA Packaging of PRD1: A Common Mechanism for Internal-membrane Viruses

Cited by 75 publications

References 90 publications

Gammasphaerolipovirus, a newly proposed bacteriophage genus, unifies viruses of halophilic archaea and thermophilic bacteria within the novel family Sphaerolipoviridae

Gammasphaerolipovirus, a newly proposed bacteriophage genus, unifies viruses of halophilic archaea and thermophilic bacteria within the novel family Sphaerolipoviridae

Genomics of Bacterial and Archaeal Viruses: Dynamics within the Prokaryotic Virosphere

Familial Relationships in Hyperthermo- and Acidophilic Archaeal Viruses

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