In vitro Dissolution Testing of Rifampicin Powder Formulations For Prediction of Plasma Concentration–Time Profiles After Inhaled Delivery

Advances in Pulmonary Drug Delivery Systems and Inhalation Formulations

“…Understanding the dissolution performance of dry powder is essential in the development of inhaled powder formulation as it affects the pharmacokinetic (PK) profile, yet there is no universally accepted method for assessing dissolution of inhaled products. Das et al [8] present the use of an in vitro dissolution study together with modelling to predict plasma concentration-time profiles of inhaled dry powder formulations. This approach can be employed to assist the design of inhaled formulation to achieve the desirable PK profile.…”