In-vitro-Diagnostik und molekulare Grundlagen von IgE-vermittelten Nahrungsmittelallergien

Kleine‐Tebbe, Jörg; Ballmer‐Weber, Barbara; Beyer, Kirsten; Erdmann, Stephan; Fuchs, Thomas; Henzgen, Margot; Huttegger, Isidor; Jappe, Uta; Jäger, Lothar; Lepp, Ute; Niggemann, B.; Raithel, Martin; Reese, Imke; Saloga, Joachim; Szépfalusi, Zsolt; Vieths, Stefan; Worm, Margitta; Zuberbier, Torsten

doi:10.5414/alp32177

Cited by 16 publications

(27 citation statements)

References 94 publications

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“…Kreuzreaktive Allergene (Bet-v-1-Homologe) finden sich in einer Reihe von Allergenen von Pollen, Kern-und Steinobst, Nüssen sowie in Gemüse und Hülsenfrüchten (Tabelle 2). Bei einer entsprechenden Anamnese für eine birkenpollenassoziierte Nahrungsmittelallergie sollte daher das sIgE gegen rBet v 1 bestimmt werden [2,3]. Der Therapieerfolg einer SIT gegen Birkenpollen kann in Abhängigkeit von dem vorhandenen Sensibilisierungsmuster sehr unterschiedlich ausfallen.…”

Section: Inhalationsallergieunclassified

“…Als kreuzreagierende Kohlenhydrat-Determinanten (cross reacting carbohydrade determinants/CCD) werden kohlenhydrathaltige Epitope der Glykoproteine bezeichnet [1,2,4,7]. Es werden zwei Typen von CCD unterschieden, nämlich vom MUXTyp und vom ␣-Galaktose-Typ (Tabelle 3).…”

Section: Kreuzreagierende Kohlenhydrat-determinanten (Ccd)unclassified

“…Hierbei werden bereits heute kommerziell verfüg-bare Diagnostika durch Fettdruck gekennzeichnet. Wichtig scheint bereits einleitend zu betonen, dass nicht alles, was heutzutage diagnostisch möglich ist, auch sinnvollerweise in der Routinediagnostik eingesetzt werden sollte [2,3].…”

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In‐vitro‐Allergiediagnostik aktuell

Treudler¹

2012

J Deutsche Derma Gesell

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Section: Inhalationsallergieunclassified

Section: Kreuzreagierende Kohlenhydrat-determinanten (Ccd)unclassified

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In‐vitro‐Allergiediagnostik aktuell

Treudler¹

2012

J Deutsche Derma Gesell

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“…Clinical allergology profits from the rapid advance in precise molecular biological methods. Molecular characteristics of individual components in allergen extracts and their targeted use in diagnostics allows for detection of specific IgE antibodies (sIgE) and thus for component‐resolved diagnostics (CRD; Table 1) [1–3]. The following internet data banks provide an overview of the allergens identified to date: http://www.allergome.org, http://www.allergen.org, http://www.meduniwien.ac.at/allergens/allfam.…”

Section: Introductionmentioning

confidence: 99%

Update on in vitro allergy diagnostics

Treudler

2012

J Deutsche Derma Gesell

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Component-resolved diagnostics (CRD) have become of growing importance in clinical investigation of IgE-mediated allergies. This review updates the current use of CRD in respiratory allergies (e. g. to pollen, animal dander, mites, latex), as well as in allergies to hymenoptera venom or in food allergies to plants (e. g. Bet v 1 homologues, lipid transfer proteins, storage proteins) or to animal-derived food allergens (e. g. milk, meat, fish). CRD may help to elucidate the clinical relevance of an allergic sensitization. In some cases, CRD may also be useful in predicting either severity of clinical reactions or the therapeutic effect of specific immunotherapy.

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“…There are different approaches for diagnosing allergies, including the skin prick test, the radio immunoassay, the enzyme-linked immunosorbent assay (ELISA) and unconventional testing such as electrodermal testing. 4 A negative multiallergen screen reduces the probability that IgE-mediated allergic disease is the cause of the patient's clinical problems. The quantification of food-specific IgE is a valuable tool that can aid in the diagnosis of symptomatic food allergy and might decrease the need for double-blind, placebo-controlled food challenges.…”

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confidence: 99%

The Effects of Various Flow Velocities on the Sensitivity of an Enzyme-Linked Immunosorbent Assay in a Fluidic Allergy Diagnostic Device

Drescher¹,

Dangers²,

Rübenhagen³

et al. 2014

Point of Care: The Journal of Near-Patient Testing &Amp; Technology

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A novel point-of-care allergy diagnostic device was used to investigate the influence of flow velocities on the sensitivity of an enzyme-linked immunosorbent assay (ELISA). Various flow rates were applied in a test setup, and the reaction sensitivity of the ELISA as well as fluidic properties within the point-of-care device such as pressure, delivery volume, and air bubble formation was analyzed. The results show that a velocity dependency seems to exist and that there is a peak in the sensitivity of the ELISA between 0.03 and 0.06 m/s in this configuration. These results can be used in future ELISAs to further improve its effectiveness and efficiency. FIGURE 3. Exemplary measurements of the flow rate at a manual feed.FIGURE 4. Exemplary measurements of the pressure at a manual feed.

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In-vitro-Diagnostik und molekulare Grundlagen von IgE-vermittelten Nahrungsmittelallergien

Cited by 16 publications

References 94 publications

In‐vitro‐Allergiediagnostik aktuell

In‐vitro‐Allergiediagnostik aktuell

Update on in vitro allergy diagnostics

The Effects of Various Flow Velocities on the Sensitivity of an Enzyme-Linked Immunosorbent Assay in a Fluidic Allergy Diagnostic Device

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