In vitro diagnosis of resistance of the cattle tick Rhipicephalus (Boophilus) microplus to fipronil in Argentina

Torrents, Jorgelina; Morel, Nicolás; Rößner, Michael; Martinez, Norberto Claudio; Toffaletti, Jose Rodolfo; Nava, Stefano

doi:10.1007/s10493-020-00554-7

Cited by 12 publications

(3 citation statements)

References 25 publications

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“…Therefore, it is exposed to acaricide longer and has become resistant worldwide to almost all classes of chemicals. These ticks are reported as resistant to acaricide drugs [80][81][82][83][84][85][86][87][88][89][90][91] and multidrug resistant strains have been reported, also [92,93].…”

Section: Ticksmentioning

confidence: 99%

Entomopathogenic Fungi and Bacteria in a Veterinary Perspective

Ebani

Mancianti

2021

Biology

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The present study aimed to review the papers dealing with the biological activity of fungi and bacteria against some mites and ticks of veterinary interest. In particular, the attention was turned to the research regarding acarid species, Dermanyssus gallinae and Psoroptes sp., which are the cause of severe threat in farm animals and, regarding ticks, also pets. Their impact on animal and human health has been stressed, examining the weaknesses and strengths of conventional treatments. Bacillus thuringiensis, Beauveria bassiana and Metarhizium anisopliae are the most widely employed agents. Their activities have been reviewed, considering the feasibility of an in-field application and the effectiveness of the administration alone or combined with conventional and alternative drugs is reported.

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Section: Ticksmentioning

confidence: 99%

Entomopathogenic Fungi and Bacteria in a Veterinary Perspective

Ebani

Mancianti

2021

Biology

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“…For many decades the use of acaricide drugs for the control of ticks on animal hosts has been extensively applied worldwide [ 13 ], with some classes of drugs (e.g., organophosphates, pyrethroids, amidines, and macrocyclic lactones) widely used. The excessive and/or incorrect use of these compounds, through metabolic detoxification or changes in the sensitivity of the target site of drug action [ 14 ], generates the appearance of acaricide resistance in certain tick species and populations [ 15 ]. Because of ticks’ major economic impact on livestock production, resistance to acaricide drugs has been considered one of the most significant threats to veterinary medicine in the last decade [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of Parasitoid Wasps, Ixodiphagus spp. (Hymenoptera: Encyrtidae), in Tick Control

et al. 2023

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Species of Ixodiphagus (Hymenoptera: Encyrtidae) are parasitoid wasps whose immature forms develop inside ixodid and argasid ticks (Acari: Ixodida). Following oviposition by adult female wasps into the idiosoma of ticks, larvae hatch and start feeding on their internal contents, eventually emerging as adult wasps from the body of the dead ticks. Species of Ixodiphagus have been reported as parasitoids of 21 species of ticks distributed across 7 genera. There are at least ten species described in the genus, with Ixodiphagus hookeri being the most studied as an agent for biological control of ticks. Although attempts of tick control by means of this parasitoid largely failed, in a small-scale study 150,000 specimens of I. hookeri were released over a 1-year period in a pasture where a small cattle population was kept, resulting in an overall reduction in the number of Amblyomma variegatum ticks per animal. This review discusses current scientific information about Ixodiphagus spp., focusing on the role of this parasitoid in the control of ticks. The interactions between these wasps and the ticks’ population are also discussed, focusing on the many biological and logistical challenges, with limitations of this control method for reducing tick populations under natural conditions.

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“…Resistance has become more difficult since the emergence of multi-resistant populations in 2009 [7]. It has been observed over time that, as resistance to a certain drug group develops, the drug group is substituted by another compound, to achieve greater efficacy in treatments [8,9]. This not only leads to resistance problems but also to contamination of the environment, risk of direct contamination of operators, and the risk of residues in food of livestock origin [10].…”

Section: Introductionmentioning

confidence: 99%

Phenotypic and Target-Directed Screening Yields New Acaricidal Alternatives for the Control of Ticks

et al. 2022

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Rhipicephalus microplus, the “common cattle tick”, is the most important ectoparasite in livestock worldwide due to the economic and health losses it produces. This tick is a vector for pathogens of several tick-borne diseases. In Latin American countries, damages reach approximately USD 500 million annually due to tick infections, as well as tick-borne diseases. Currently, resistant populations for every chemical group of acaricides have been reported, posing a serious problem for tick control. This study aims to find new alternatives for controlling resistant ticks with compounds derived from small synthetic organic molecules and natural origins. Using BME26 embryonic cells, we performed phenotypic screening of 44 natural extracts from 10 Mexican plants used in traditional medicine, and 33 compounds selected from our chemical collection. We found 10 extracts and 13 compounds that inhibited cell growth by 50% at 50 µg/mL and 100 µM, respectively; the dose-response profile of two of them was characterized, and these compounds were assayed in vitro against different life stages of Rhipicephalus microplus. We also performed a target-directed screening of the activity of triosephosphate isomerase, using 86 compounds selected from our chemical collection. In this collection, we found the most potent and selective inhibitor of tick triosephosphate isomerase reported until now. Two other compounds had a potent acaricidal effect in vitro using adults and larvae when compared with other acaricides such as ivermectin and Amitraz. Those compounds were also selective to the ticks compared with the cytotoxicity in mammalian cells like macrophages or bovine spermatozoids. They also had a good toxicological profile, resulting in promising acaricidal compounds for tick control in cattle raising.

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In vitro diagnosis of resistance of the cattle tick Rhipicephalus (Boophilus) microplus to fipronil in Argentina

Cited by 12 publications

References 25 publications

Entomopathogenic Fungi and Bacteria in a Veterinary Perspective

Entomopathogenic Fungi and Bacteria in a Veterinary Perspective

The Role of Parasitoid Wasps, Ixodiphagus spp. (Hymenoptera: Encyrtidae), in Tick Control

Phenotypic and Target-Directed Screening Yields New Acaricidal Alternatives for the Control of Ticks

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