In vitro degradation profiles and in vivo biomaterial–tissue interactions of microwell array delivery devices

Hadavi, Elahe; Vries, Rick de; Smink, Alexandra M.; Haan, Bart de; Leijten, Jeroen; Schwab, Leendert W.; Karperien, Marcel; Vos, Paul de; Dijkstra, Pieter J.; Apeldoorn, Aart van

doi:10.1002/jbm.b.34686

Cited by 6 publications

(2 citation statements)

References 43 publications

(60 reference statements)

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“…Either in cattle or sheep CE cysts, the presence of a granulomatous reaction is indicative of a foreign body response, which has been widely studied in the biomaterials field [ 25 – 27 ], where after an acute inflammatory reaction, there is chronic inflammation, followed by either granulomatous tissue or the development of a fibrous capsule [ 27 ]. Here we report that in non-fertile CE cysts, this fibrous capsule changes its location; in cattle it is found surrounding the chronic inflammation tissue, whereas in sheep is found directly surrounding the laminated layer.…”

Section: Discussionmentioning

confidence: 99%

Response patterns in adventitial layer of Echinococcus granulosus sensu stricto cysts from naturally infected cattle and sheep

Hidalgo

Stoore

Baquedano

et al. 2021

Vet Res

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Cystic echinococcosis is a zoonotic disease caused by the metacestode of Echinococcus granulosus sensu lato. The disease is characterized by the development of cystic structures inside viscera of the intermediate host, mainly liver and lungs. These cysts are formed by three layers: germinal, laminated, and adventitial layer, the latter being the local host immune response. Metacestodes that develop protoscoleces, the infective stage to the definitive host, are termed fertile, whereas cysts that do not produce protoscoleces are termed non-fertile. Sheep usually harbor fertile cysts while cattle usually harbor non-fertile cysts. Adventitial layers with fibrotic resolution are associated to fertile cysts, whereas a granulomatous reaction is associated with non-fertile cysts. The aim of this study was to analyze cellular distribution in the adventitial layer of fertile and non-fertile E. granulosus sensu stricto cysts found in liver and lungs of cattle and sheep. A total of 418 cysts were analyzed, 203 from cattle (8 fertile and 195 non-fertile) and 215 from sheep (64 fertile and 151 non-fertile). Fertile cysts from cattle showed mixed patterns of response, with fibrotic resolution and presence of granulomatous response in direct contact with the laminated layer, while sheep fertile cysts always displayed fibrotic resolution next to the laminated layer. Cattle non-fertile cysts display a granulomatous reaction in direct contact with the laminated layer, whereas sheep non-fertile cysts display a granulomatous reaction, but in direct contact with the fibrotic resolution. This shows that cattle and sheep cystic echinococcosis cysts have distinct local immune response patterns, which are associated to metacestode fertility.

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Section: Discussionmentioning

confidence: 99%

Response patterns in adventitial layer of Echinococcus granulosus sensu stricto cysts from naturally infected cattle and sheep

Hidalgo

Stoore

Baquedano

et al. 2021

Vet Res

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“…So, replacing all or some of the natural L -amino acids with D -amino acids, and then comparing their differences in degradability, would gain important insights in factors affecting degradability of polymers. Polymer materials were either degraded as grounded powder in phosphate buffered solution (PBS) that simulates human body environment or as membrane in aqueous soil suspension that simulates soil degradation [ 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Homochirality of Dipeptide to Polymers’ Degradation

Yang

et al. 2020

Polymers

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As natural polymer materials, proteins are readily biodegradable, interestingly, the synthetic polyamides (PAs) that are based on the same amide bonds (also called peptide bonds in proteins) are barely degradable. Whether did the chirality and configuration of the amino acids play an important role. By using different configuration of amino acids, 4 types of polyamide-imides (PAIs) containing dipeptides of LL, DL, LD, and DD configurations, respectively, were synthesized. It was found that the PAIs based on natural LL configuration of dipeptide structure are much more readily biodegradable than those based on non-natural LD, DL, and DD configuration of dipeptides. It was confirmed that the natural L-configuration of amino acids play a critical role in degradability of proteins. And it also suggested that different type and amount of peptide fragments can be introduced in polymer to create series of polymer materials that can be biodegraded at controllable speed.

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Scaffolds for Encapsulation of Stem Cell-Derived β Cells

de Vries,

van Apeldoorn

2023

Pluripotent Stem Cell Therapy for Diabetes

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In vitro degradation profiles and in vivo biomaterial–tissue interactions of microwell array delivery devices

Cited by 6 publications

References 43 publications

Response patterns in adventitial layer of Echinococcus granulosus sensu stricto cysts from naturally infected cattle and sheep

Response patterns in adventitial layer of Echinococcus granulosus sensu stricto cysts from naturally infected cattle and sheep

Effect of Homochirality of Dipeptide to Polymers’ Degradation

Scaffolds for Encapsulation of Stem Cell-Derived β Cells

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