In vitro degradation of three-dimensional chitosan/apatite composite rods prepared via in situ precipitation

Pu, Ximing; Yao, Qingqing; Yang, Yun Jung; Sun, Zhen-Zhen; Zhang, Qiqing

doi:10.1016/j.ijbiomac.2012.07.008

Cited by 13 publications

(5 citation statements)

References 35 publications

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“…A high oxidation ratio caused a rapid decline in the pH value. Fourteen days later, the pH value of the degradation liquid decreased from the initial value of 7.40 to 7.18, 7.13, and 7.10, which indicates that changes in the pH values were correlated with the changing degradation rates of the material [18]. After degradation, slightly acidic small-molecule substances were obtained, which indicates a decline in the pH value.…”

Section: The Change Of Ph Value Of the Degradation Liquidmentioning

confidence: 94%

Research on the degradation performance of the lotus nanofibers-alginate porous materials

Gong

Han

Zhang

et al. 2015

Polymer Degradation and Stability

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Section: The Change Of Ph Value Of the Degradation Liquidmentioning

confidence: 94%

Research on the degradation performance of the lotus nanofibers-alginate porous materials

Gong

Han

Zhang

et al. 2015

Polymer Degradation and Stability

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“…Gu and co-workers fabricated a chitosan-poly(ε-caprolactone-co-2-oxepane-1,5-dione) blend which demonstrated a slower degradation rate compared to native chitosan [102]. Compact rods consisting of chitosan and apatite were prepared by Pu et al [103]. Th ese rods were found to promote cell proliferation and maintain their integrity for much longer compared to native chitosan rods [103].…”

Section: Wound Healing/tissue Regenerationmentioning

confidence: 99%

“…Compact rods consisting of chitosan and apatite were prepared by Pu et al [103]. Th ese rods were found to promote cell proliferation and maintain their integrity for much longer compared to native chitosan rods [103]. Kwon et al utilized a chitosan hydrogel in the presence of valproic acid as a 3-D substrate for the attachment, proliferation and diff erentiation of rat muscle-derived stem cells [104].…”

Section: Wound Healing/tissue Regenerationmentioning

confidence: 99%

Chitosan as an Advanced Healthcare Material

Jardine

Sayed

2014

Advanced Biomaterials and Biodevices

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Chitin and chitosan are renewable biopolymers with inherently favourable properties allowing diverse chemical modifi cation that generates novel materials ideal for biomedical applications. Chitin itself has very poor aqueous solubility and hence found limited utility. For this reason the use of chitosan, in particular, modifi ed chitosan, has increased exponentially in biomedical applications in recent years. Th e review of chitosan as a health care material includes wound healing or tissue regeneration, drug delivery and antimicrobial studies. Specialist applications are vast and due to the shortened publication process, biomedical applications of chitosan may warrant more frequent reviews.In this review, highlights of recent research on the synthesis and analysis of chitin and chitosan based nanomaterials and nanofi bres will be covered. A detailed review of the synthetic transformation of chitosan that further added value by enabling diverse application has been discussed. Th e value of copolymerization and graft ing of biodegradable synthetic polymers with chitosan in order to improve stability and control of the functional biomaterial has been a major driver in the biotechnological innovation.

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“…The use of chitosan [poly-(β-1/4)-2-amino-2-deoxy-Dglucopyranose] has been described in several preclinical studies and tested in tissue bioengineering of bone (Zhao et al, 2002;Kim et al, 2004;Yoshida et al, 2004;Teng et al, 2008;Yuan et al, 2008;Liu et al, 2009;Xianmiao et al, 2009;Li et al, 2010;Mota et al, 2012;Pu et al, 2012;Zhang et al, 2012;Azevedo et al, 2014;Fan et al, 2014;Rodriguez-Vázquez et al, 2015;Vega-Ruiz et al, 2017) neural tissue (Simoes et al, 2011;Meyer et al, 2016;Ghasemi Hamidabadi et al, 2017;Nawrotek et al, 2017;Zhao et al, 2017) and soft tissue (Gobin et al, 2006;Paulo et al, 2009;Tchemtchoua et al, 2011;Udpa et al, 2013;Zou et al, 2017). Chitosan is a copolymer derived from the alkaline deacetylation of chitin and made of N-acetyl-D-glucosamine and D-glucosamine bonds and β bonds in which glucosamine is the main repeating unit in its structure (Rodriguez-Vázquez et al, 2015).…”

mentioning

confidence: 99%

“…Due to challenges frequently encountered in the repair of the sellar floor specifically the bony part, we intended to address this problem with a chitosan scaffold. This material has shown to provide useful characteristics facilitating bone regeneration (Zhao et al, 2002;Kim et al, 2004;Yoshida et al, 2004;Teng et al, 2008;Yuan et al, 2008;Liu et al, 2009;Xianmiao et al, 2009;Li et al, 2010;Mota et al, 2012;Pu et al, 2012;Zhang et al, 2012;Azevedo et al, 2014;Fan et al, 2014;Rodriguez-Vázquez et al, 2015;Vega-Ruiz et al, 2017), and scaffolding properties characterized by infiltration of fibroblasts, with subsequent deposits of organized collagen fibers, without evidence of infection or abnormal healing (Sandoval-Sánchez et al, 2012).…”

mentioning

confidence: 99%

Bilaminar Chitosan Scaffold for Sellar Floor Repair in Transsphenoidal Surgery

Ramos-Zúñiga

López-González

Segura-Durán

2020

Front. Bioeng. Biotechnol.

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Background: Endoscopic endonasal transsphenoidal surgery (EETS) is a standard technique used to approach sellar tumors. It is relatively safe, minimally invasive and carries a low risk of complications. However, one of the common complications reported with this technique is CSF leakage which causes morbidity, an increase in recovery time and hospital costs. This complication usually occurs from violation of the diaphragma sellae and a defect in the structures of the sellar floor or incomplete repair. In this article we report the first case with the use of a novel bilaminar chitosan scaffold which can be potentially used in the repair of the sellar floor, primarily aiming to the bony part of this structure. Case Presentation: After a personalized design employing a tissue engineering strategy, we reconstructed the sellar floor in a 65-year-old woman who had undergone EETS for a pituitary adenoma with progressive bilateral visual loss. To repair the bony defect of the sellar floor, we used a novel bilaminar chitosan scaffold. The patient had an unremarkable postoperative course with no evidence of CSF leak. The polymer was well tolerated without toxicity, infection or complications. After 2 years of follow up the patient remains neurologically intact, and in good endocrinological status. Conclusion: This is the first report of the use of this biomaterial and its biocompatibility in a clinical setting for the repair of the sellar floor during EETS. Our experience with chitosan bilaminar scaffold and in several preclinical studies in the literature have demonstrated good biocompatibility and effective bioengineered bone regeneration due to its excellent osteoconductive properties, this study pretends to be one landmark for further clinical research and larger case series with the use of this personalized tissue engineering materials in order to see they real efficacy to increase the surgeon armamentarium.

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In vitro degradation of three-dimensional chitosan/apatite composite rods prepared via in situ precipitation

Cited by 13 publications

References 35 publications

Research on the degradation performance of the lotus nanofibers-alginate porous materials

Research on the degradation performance of the lotus nanofibers-alginate porous materials

Chitosan as an Advanced Healthcare Material

Bilaminar Chitosan Scaffold for Sellar Floor Repair in Transsphenoidal Surgery

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