In vitro degradation of porous PLLA/pearl powder composite scaffolds

Liu, Y.S.; Huang, Qian; Kienzle, Arne; Müller, Wernér E.G.; Feng, Qingling

doi:10.1016/j.msec.2014.02.007

Cited by 51 publications

(36 citation statements)

References 34 publications

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“…Gong et al [19] carried out in vitro degradation study of porous PLLA scaffolds over 39 weeks, and the scaffolds degraded at a slow rate due to its highly porous structure in terms of weight water uptake and structure change. As reported by Liu et al [20] , PLLA porous scaffolds exhibited a reduction in mass and molecular weight during an in vitro degradation time of 200 days. Rodrigues et al [21] studied degradation process of porous PLA scaffold immersed in phosphate-buffered-saline solution, and revealed that there was no significant change in molecular weight over 8 weeks.…”

Section: Degradation Behavioursupporting

confidence: 59%

Research into biodegradable polymeric stents: a review of experimental and modelling work

Qiu¹,

Zhao²

2018

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Bioresorbable stents (BRSs) are regarded as the next-generation medical devices to treat blocked or diseased arteries.The use of BRSs aims to reduce the risk of late stent thrombosis and long-term tissue inflammation associated with permanent metallic stents. BRSs are designed to relieve symptoms immediately and also provide mechanical support for an appropriate time period before they are fully absorbed by human body. To promote clinical adoption of BRSs or even to substitute metallic stents, the mechanical performance of BRSs needs to be thoroughly investigated and quantitatively characterised, especially over the full period of degradation. This paper offers a review of current research status of polymeric BRSs, covering both experimental and modelling work. Review of experimental studies highlighted the effects of stent designs and materials on the behaviour of polymeric BRSs. Computational work was able to simulate crimping, expansion and degradation of polymeric BRSs and the results were useful for performance assessment. In summary, the development of polymeric BRSs is still at an early stage, and further research is urgently required for a better understanding and control of their mechanical performance.

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Section: Degradation Behavioursupporting

confidence: 59%

Research into biodegradable polymeric stents: a review of experimental and modelling work

Qiu¹,

Zhao²

2018

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“…Liu et al 36 reported that degradation is closely related to water absorption and/or pore distribution. The results of the water absorption test and weight loss amount, indicating degradation, were correlated.…”

Section: Water Absorption and In Vitro Degradation Properties Of Pcl/mentioning

confidence: 99%

Enhanced biocompatibility and osteogenic potential of mesoporous magnesium silicate/polycaprolactone/wheat protein composite scaffolds

Kang

Wei

Shin

et al. 2018

IJN

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Background Successful bone tissue engineering using scaffolds is primarily dependent on the properties of the scaffold, including biocompatibility, highly interconnected porosity, and mechanical integrity. Methods In this study, we propose new composite scaffolds consisting of mesoporous magnesium silicate (m_MS), polycaprolactone (PCL), and wheat protein (WP) manufactured by a rapid prototyping technique to provide a micro/macro porous structure. Experimental groups were set based on the component ratio: (1) WP0% (m_MS:PCL:WP =30:70:0 weight per weight; w/w); (2) WP15% (m_MS:PCL:WP =30:55:15 w/w); (3) WP30% (m_MS:PCL:WP =30:40:30 w/w). Results Evaluation of the properties of fabricated scaffolds indicated that increasing the amount of WP improved the surface hydrophilicity and biodegradability of m_MS/PCL/WP composites, while reducing the mechanical strength. Moreover, experiments were performed to confirm the biocompatibility and osteogenic differentiation of human mesenchymal stem cells (MSCs) according to the component ratio of the scaffold. The results confirmed that the content of WP affects proliferation and osteogenic differentiation of MSCs. Based on the last day of the experiment, ie, the 14th day, the proliferation based on the amount of DNA was the best in the WP30% group, but all of the markers measured by PCR were the most expressed in the WP15% group. Conclusion These results suggest that the m_MS/PCL/WP composite is a promising candidate for use as a scaffold in cell-based bone regeneration.

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“…To achieve an effective design for proposed devices, it is important to suppress the initial PGA decomposition. For examples, a crystallinity control of degradable materials by heat treatments or incorporation of basic materials is an effective method for improving the degradation characteristics [24][25][26][27][28] . Recently, an additive manufacturing has been received considerable attentions in several elds, because it has a lot of exibility in the structural design.…”

Section: Mechanical Properties Of Compositesmentioning

confidence: 99%

“…A decomposition rate of degradable plastics such as PLA and PGA can be supressed by using high-molecular-weight ones and incorporation of basic materials 10,[24][25][26][27][28]31) . If calcium phosphates or calcium carbonates are employed as the basic materials, the bone ingrowth could be promoted by the calcium release.…”

Section: Histological Analysismentioning

confidence: 99%

Preparation and In Vivo Study of Porous Titanium–Polyglycolide Composite

et al. 2016

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Porous materials show low Young s moduli and excellent bonding to living bone. However, the strength of such materials is often insufcient in the initial stage of implantation. Thus, the objective of this study was to increase the strength of porous titanium by lling the pores with polyglycolide (PGA), a biodegradable plastic. PGA powder was prepared via the thermal decomposition of sodium chloroacetate at 433 K. The PGA was then introduced into the pores of porous Ti (porosity: 60%) using two methods: (i) centrifugal packing and heating and (ii) heat injection. In the latter method, almost all pores were lled by PGA; the lling fraction was measured to be 65-85% regardless of the injection temperature. When the pores in the porous Ti were lled with PGA, the compressive strength increased drastically from 40 to 100 MPa. The increased strength is comparable to that of cortical bone. In addition, the strength increased with increasing injection temperature. In an animal test, unfavourable autopsy ndings, such as suppuration, bleeding, and hyperplasia of the connective tissue, could not be con rmed in rats and no bone was observed in the pores of the Ti-PGA composite. Decomposition of PGA lowered the surrounding pH, it was found to inhibit bone formation in the pores of the porous Ti. It is important to control the decomposition rate of PGA.

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In vitro degradation of porous PLLA/pearl powder composite scaffolds

Cited by 51 publications

References 34 publications

Research into biodegradable polymeric stents: a review of experimental and modelling work

Research into biodegradable polymeric stents: a review of experimental and modelling work

Enhanced biocompatibility and osteogenic potential of mesoporous magnesium silicate/polycaprolactone/wheat protein composite scaffolds

Preparation and In Vivo Study of Porous Titanium–Polyglycolide Composite

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