In vitro degradation, hemolysis and MC3T3-E1 cell adhesion of biodegradable Mg–Zn alloy

Zhang, Shaoxiang; Li, Jianan; Song, Yang; Zhao, Changli; Zhang, Xiaonong; Xie, Changsheng; Zhang, Yan; Tao, Hairong; He, Yaohua; Jiang, Yao; Bian, Yujun

doi:10.1016/j.msec.2009.03.001

Cited by 271 publications

(126 citation statements)

References 22 publications

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“…The improvement of corrosion resistance of the composites can be understood by the positive effect of produced Zn and Mg-Zn intermetallic compounds. As demonstrated in previous works [19][20][21][22], Zn is able to significantly improve the corrosion resistance of Mg matrix. On the other hand, the above results suggested that the remaining ZnO and newly produced MgO had negative effects on the corrosion resistance of these composites.…”

Section: Composition and Microstructure Of Compositessupporting

confidence: 61%

“…The work indicated that in situ reaction products including MgO, Zn, and intermetallic compounds significantly reinforced mechanical performance of the fabricated composites. Previous research has shown that Zn is an effective additive that improves the mechanical properties as well as the corrosion resistance of Mg-based biomaterials [19][20][21][22]. In addition, Zn is also biocompatible and biodegradable with a daily moderate amount of allowance [23,24].…”

Section: Introductionmentioning

confidence: 99%

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In Vitro Corrosion Properties of Mg Matrix In Situ Composites Fabricated by Spark Plasma Sintering

Cao

Pham

Narita

et al. 2017

Metals

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Mg matrix in situ composites were fabricated from Mg and ZnO powder by a spark plasma sintering method. The composition and microstructure of the sintered samples were characterized. Corrosion properties of fabricated composites were evaluated by immersion and by electrochemical tests using Hanks' solution. The results showed that the formation of in situ products improved significantly the corrosion resistance of the fabricated composites compared with pure Mg; Mg-10 wt % ZnO composites especially exhibited the lowest corrosion rate. In addition, an energy-dispersive X-ray (EDX) analysis showed that calcium phosphate formed as a corrosion product on the surface of Mg-10 wt % ZnO composites, while Mg(OH)2 appeared as a corrosion product on the surface of Mg-20 wt % ZnO composite. The findings suggested Mg-10 wt % ZnO composite as a potential candidate for temporary implant application.

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Section: Composition and Microstructure Of Compositessupporting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

In Vitro Corrosion Properties of Mg Matrix In Situ Composites Fabricated by Spark Plasma Sintering

Cao

Pham

Narita

et al. 2017

Metals

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“…Boehlert et al investigated the mechanical performance of as-cast Mg-Zn alloys by controlling the Zn content, finding that the tensile strength was enhanced from 62 MPa to 114 MPa [12]. Zhang et al [13] studied the degradation behavior of extruded Mg-Zn alloys, suggesting that Zn could effectively reduce the degradation rate of Mg in simulated body fluid (SBF).…”

Section: Introductionmentioning

confidence: 99%

Influence of Alloying Treatment and Rapid Solidification on the Degradation Behavior and Mechanical Properties of Mg

Chen

Wang

et al. 2016

Metals

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Magnesium (Mg) has drawn increasing attention as a tissue engineering material. However, there have been very few studies of laser-melted Mg-Zn alloys. In this study, four binary Mg-xZn (x = 2, 4, 6 and 8 wt. %) alloys were fabricated by laser melting. The influence of zinc (Zn) content and technique on the degradation behavior and mechanical properties of Mg were discussed. Results revealed that Mg-xZn alloys consisted of an α-Mg matrix and MgZn phases, which dispersed at the grain boundaries. In addition, the MgZn phase increased with the increase in Zn content. The laser-melted alloy had fine homogenous grains, with an average grain size of approximately 15 µm. Grain growth was effectively inhibited due to the precipitation of the MgZn phase and rapid solidification. Grain refinement consequently slowed down the degradation rate, with Zn content increasing to 6 wt. %. However, a further increase of Zn content accelerated the degradation rate due to the galvanic couple effect between α-Mg and MgZn. Moreover, the mechanical properties were improved due to the grain refinement and reinforcement of the MgZn phase.

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“…Previous studies have confirmed that magnesium alloys have good biocompatibility, may promote osteocyte growth and may induce production of osteoblasts and osteocytes (11)(12)(13)(14)(15). Owing to suitable mechanical property and good biocompatibility, high specific strength and specific stiffness, degradable magnesium alloys can be utilized in many aspects such as bone repair material, coronary artery stent and porous repair material.…”

Section: Introductionmentioning

confidence: 99%

In vivo degradation behavior and biocompatibility of Mg-Nd-Zn-Zr alloy at early stage

Wang

Zhu²,

He³

et al. 2011

Int J Mol Med

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Abstract. The neotype magnesium alloy, Mg-Nd-Zn-Zr (NZK) alloy, was implanted into the rabbit femur to investigate its in vivo degradation behavior and biocompatibility. Seventy-two New Zealand white rabbits were randomly divided into the NZK alloy group, titanium alloy group and sham-operated group. Then NZK alloy rods were embedded in the rabbit femur in the NZK alloy group, titanium alloy rods were embedded in the titanium alloy group, and only bone tunnel was established in the sham-operated group. Prior to surgery and at 1, 7, 14, 28 and 56 days after operation, the serum alanine transaminase, creatinine, creatine kinase and magnesium ion concentration were examined in each group. An X-ray of the implanted region was taken at 7, 14, 28 and 56 days after implantation. The pathological changes in heart, liver, kidney and bone from the implant region were examined at 28 and 56 days postoperatively. The degradation behavior of the NZK alloy was observed using scanning electron microscope with an energy dispersive spectroscopy system. There were no significant differences in serum alanine transaminase, creatinine, creatine kinase and magnesium ion concentrations among each group at the same time point (P>0.05). The histology of heart, liver, kidney and bone from implant region was altered. The results demonstrate that the NZK alloy implanted into the rabbit femur could be absorbed gradually, and that the NZK alloy has excellent biocompatibility in vivo. IntroductionTraditionally, materials used for internal fixation in orthopedics are metals such as titanium alloy and stainless steel. The elastic modulus of these metals are greater than that of human bone, thus they can cause a stress shielding effect which can decrease bone strength and delay bone healing. Moreover, these implants may undergo corrosion or abrasion and will release toxic ions or particles into the human body, which result in chronic inflammatory and bone dissolution (1). In addition, the metal materials used for bone fracture fixation are permanent and require removal by an additional surgical procedure, which results in unnecessary morbidity (1-5). Therefore, the development of resorbable metal materials to solve these problems has become the focus of research (6-8).Magnesium alloys, which are easily corroded in solutions, especially in the presence of chloride ions, and have good biocompatibility have become promising degradable biomaterials, attracting much attention in recent years (1,2,9,10). Previous studies have confirmed that magnesium alloys have good biocompatibility, may promote osteocyte growth and may induce production of osteoblasts and osteocytes (11)(12)(13)(14)(15). Owing to suitable mechanical property and good biocompatibility, high specific strength and specific stiffness, degradable magnesium alloys can be utilized in many aspects such as bone repair material, coronary artery stent and porous repair material. However, fast corrosion rates and the appearance of a gas bubble in the physiological environment impose severe limit...

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In vitro degradation, hemolysis and MC3T3-E1 cell adhesion of biodegradable Mg–Zn alloy

Cited by 271 publications

References 22 publications

In Vitro Corrosion Properties of Mg Matrix In Situ Composites Fabricated by Spark Plasma Sintering

In Vitro Corrosion Properties of Mg Matrix In Situ Composites Fabricated by Spark Plasma Sintering

Influence of Alloying Treatment and Rapid Solidification on the Degradation Behavior and Mechanical Properties of Mg

In vivo degradation behavior and biocompatibility of Mg-Nd-Zn-Zr alloy at early stage

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