In vitro degradation and multi-antibacterial mechanisms of β-cyclodextrin@curcumin embodied Mg(OH)2/MAO coating on AZ31 magnesium alloy

Xue, Kui; Tan, Pei-Hong; Zhao, Ze-Hui; Cui, Lan-Yue; Kannan, M. Bobby; Li, Shuoqi; Liu, Cheng-Bao; Zou, Yuhong; Zhang, Fen; Chen, Zhuoyuan; Zeng, Rong‐Chang

doi:10.1016/j.jmst.2022.04.053

Cited by 38 publications

(18 citation statements)

References 51 publications

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“…Firstly, the thermal conductivity of pure Mg is higher than that of MAO [ 32 ], which benefited the transfer of heat from the surface of the substrate to the solution. Secondly, the increased temperature of the solution further promoted the corrosion of pure Mg and produced heat [ 36 , 66 ]. As shown in Figure 7 d, the temperature of the MAO/PMTMS@(Hemin-CaP) coating exhibited a stable on-off behavior.…”

Section: Resultsmentioning

confidence: 99%

“…Under NIR irradiation, its antibacterial efficiency against S. aureus and E. coli was 92.3% and 92.0%, respectively. In fact, the MAO coating also had a certain antibacterial ability, which can be attributed to its increased pH value [ 36 ]. The increased temperature of the MAO coating after exposure to NIR light also led to an improved antibacterial efficiency.…”

Section: Resultsmentioning

confidence: 99%

“…Photoactivated sterilization has received more attention in recent years due to its advantages of rapid and effective bacteriostasis and broad-spectrum antibacterial activity [ 28 ]. To date, a variety of photo-responsive materials, such as inorganic nanoparticles [ 29 , 30 ], layered double hydroxides [ 31 , 32 ], cyanine-based agents [ 33 , 34 ], porphyrin-based agents [ 35 ] and diketone-based agents [ 36 ] have been attempted to fabricate antibacterial coatings on the surface of bone implants to deal with IAIs. Thereinto, porphyrins and porphyrin derivatives have considerable potential in biomedical applications because of their distinctive light-harvesting properties and photophysical properties [ 37 ].…”

Section: Introductionmentioning

confidence: 99%

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In Vitro Degradation and Photoactivated Antibacterial Activity of a Hemin-CaP Microsphere-Loaded Coating on Pure Magnesium

Long

Song

Tian

et al. 2022

JFB

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Photoactivated sterilization has received more attention in dealing with implant-associated infections due to its advantages of rapid and effective bacteriostasis and broad-spectrum antibacterial activity. Herein, a micro-arc oxidation (MAO)/polymethyltrimethoxysilane (PMTMS)@hemin-induced calcium-bearing phosphate microsphere (Hemin-CaP) coating was prepared on pure magnesium (Mg) via MAO processing and dipping treatments. The morphology and composition of the coating were characterized via scanning electron microscopy, Fourier transform infrared spectrometer, X-ray diffractometer and X-ray photoelectron spectrometer. Corrosion behavior was evaluated through electrochemical and hydrogen evolution tests. The release of Fe3+ ions at different immersion times was measured with an atomic absorption spectrophotometer. Antibacterial performance and cytotoxicity were assessed using the spread plate method, MTT assay and live/dead staining experiment. The results showed that the corrosion current density of the MAO/PMTMS@(Hemin-CaP) coating (4.41 × 10−8 A·cm−2) was decreased by two orders of magnitude compared to that of pure Mg (3.12 × 10−6 A·cm−2). Photoactivated antibacterial efficiencies of the Hemin-CaP microspheres and MAO/PMTMS@(Hemin-CaP) coating reached about 99% and 92%, respectively, which we attributed to the photothermal and photodynamic properties of hemin with a porphyrin ring. Moreover, based on the release of Fe3+ ions, the MC3T3-E1 pre-osteoblasts’ viability reached up to 125% after a 72 h culture, indicating a positive effect of the coating in promoting cell growth. Thus, this novel composite coating holds a promising application as bone implants.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In Vitro Degradation and Photoactivated Antibacterial Activity of a Hemin-CaP Microsphere-Loaded Coating on Pure Magnesium

Long

Song

Tian

et al. 2022

JFB

Self Cite

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“…The natural components from plants are considerable antimicrobial agents may that can substitute the current antibiotics, which are facing increasingly evolving resistance by microorganisms (Figure 5) (143)(144)(145)(146)(147)(148)(149)(150)(151)(152)(153)(154)(155). In an in vitro study, curcumin inhibited the growth of antibiotic-resistant Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae isolated from burn wound infections and showed synergism with meropenem (156). On gastrointestinal bacteria of human and bovine origin, Cur inhibited Firmicutes [Clostridioides difficile and Acetoanaerobium (Clostridium) sticklandii] but did not affect Bacteroidetes (Bacteroides fragilis and Prevotella bryantii) (157).…”

Section: Anti-microbial Impacts Of Curcuminmentioning

confidence: 99%

Impacts of turmeric and its principal bioactive curcumin on human health: Pharmaceutical, medicinal, and food applications: A comprehensive review

et al. 2023

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The yellow polyphenolic pigment known as curcumin, originating from the rhizome of the turmeric plant Curcuma longa L., has been utilized for ages in ancient medicine, as well as in cooking and food coloring. Recently, the biological activities of turmeric and curcumin have been thoroughly investigated. The studies mainly focused on their antioxidant, antitumor, anti-inflammatory, neuroprotective, hepatoprotective, and cardioprotective impacts. This review seeks to provide an in-depth, detailed discussion of curcumin usage within the food processing industries and its effect on health support and disease prevention. Curcumin’s bioavailability, bio-efficacy, and bio-safety characteristics, as well as its side effects and quality standards, are also discussed. Finally, curcumin’s multifaceted uses, food appeal enhancement, agro-industrial techniques counteracting its instability and low bioavailability, nanotechnology and focused drug delivery systems to increase its bioavailability, and prospective clinical use tactics are all discussed.

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“…The formation of thin films on metal surfaces is the most effective way to mitigate corrosion through surface modification technology, forming chemical inhibition systems or physical barriers. − Coatings with excellent protection, good adhesion, and self-healing properties to metal substrates are often the basis of many research studies. , In addition, the intelligent encapsulation system of different inhibitors can effectively assess the requirements in various environments.…”

Section: Introductionmentioning

confidence: 99%

Corrosion Resistance of the GO/ZIF-8 Hybrid Loading Benzotriazole as a Multifunctional Composite Filler-Modified MgAlY Layered Double Hydroxide Coating

Chen

Dai

et al. 2022

Langmuir

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A composite coating with good load-carrying and controlled release capabilities for the corrosion inhibitor benzotriazole (BTA) was prepared while providing active and passive corrosion protection for magnesium alloy systems. In this paper, the organic corrosion inhibitor BTA was loaded into the ZIF-8/GO hybrid (GZB), and then, the GZB composite was coated with hexadecyltrimethoxysilane (HDTMS). Then, the GZB composites carried by HDTMS were made to adhere a ternary MgAlY layered double hydroxide (LDH) coating based on microarc oxidation (MAO) coating by electrophoresis (Si-MgAlY LDH coating). The successful loading of BTA by GZB composites was verified by X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM). Meanwhile, the Si-MgAlY LDH coating was characterized by X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy. The potentiodynamic polarization curves show that the corrosion current density of the Si-MgAlY LDH coating reaches (2.08 ± 0.49) × 10–9 A/cm2, which means that the Si-MgAlY LDH coating greatly improves the corrosion resistance of magnesium alloy AZ31. The Si-MgAlY LDH coating can also achieve self-healing function in harsh environments, which is attributed to the synergistic effect of passive and active protection. The composite coating is of great significance to expand the potential applications of magnesium alloys.

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In vitro degradation and multi-antibacterial mechanisms of β-cyclodextrin@curcumin embodied Mg(OH)2/MAO coating on AZ31 magnesium alloy

Cited by 38 publications

References 51 publications

In Vitro Degradation and Photoactivated Antibacterial Activity of a Hemin-CaP Microsphere-Loaded Coating on Pure Magnesium

In Vitro Degradation and Photoactivated Antibacterial Activity of a Hemin-CaP Microsphere-Loaded Coating on Pure Magnesium

Impacts of turmeric and its principal bioactive curcumin on human health: Pharmaceutical, medicinal, and food applications: A comprehensive review

Corrosion Resistance of the GO/ZIF-8 Hybrid Loading Benzotriazole as a Multifunctional Composite Filler-Modified MgAlY Layered Double Hydroxide Coating

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