In vitro cytotoxicity study of dual drug loaded chitosan/palladium nanocomposite towards HT-29 cancer cells

Dhanavel, S.; Nivethaa, E. A. K.; Narayanan, Vijaykrishnan; Stephen, A.

doi:10.1016/j.msec.2017.03.058

Cited by 54 publications

(27 citation statements)

References 56 publications

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“…Cancerous diseases are the third reason of death worldwide. Among all cases, the most common cause of death in both sexes is lung cancer, when colorectal cancer is the third cause of death among other types of cancers [1,2]. Among different groups of drugs used in chemotherapy, acridine derivatives, which are tricyclic heterocyclic compounds, have been extensively explored as potential therapeutic 1i, 1b, 1c, 1e, 1f.…”

Section: Discussionmentioning

confidence: 99%

“…Chemotherapy has many side effects such as pain, vomiting, diarrhoea, stomatitis, vascular and neuronal damage. Moreover, anticancer drugs possess poor bioavailability, fast renal clearance and can induce resistance [2][3][4]. Among drugs using to treat colon cancer, 5-fluorouracil (5-FU) is the basic one.…”

Section: Introductionmentioning

confidence: 99%

“…Among drugs using to treat colon cancer, 5-fluorouracil (5-FU) is the basic one. It inhibits DNA replication and further blocks the growth of cancer cells [2,5]. Etoposide is an anticancer drug which is the topoisomerase II inhibitor [6,7].…”

Section: Introductionmentioning

confidence: 99%

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Novel tetrahydroacridine derivatives with iodobenzoic moieties induce G0/G1 cell cycle arrest and apoptosis in A549 non-small lung cancer and HT-29 colorectal cancer cells

et al. 2019

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A series of nine tetrahydroacridine derivatives with iodobenzoic moiety were synthesized and evaluated for their cytotoxic activity against cancer cell lines-A549 (human lung adenocarcinoma), HT-29 (human colorectal adenocarcinoma) and somatic cell line-EA.hy926 (human umbilical vein cell line). All compounds displayed high cytotoxicity activity against A549 (IC 50 59.12-14.87 µM) and HT-29 (IC 50 17.32-5.90 µM) cell lines, higher than control agents-etoposide and 5-fluorouracil. Structure-activity relationship showed that the position of iodine in the substituent in the para position and longer linker most strongly enhanced the cytotoxic effect. Among derivatives, 1i turned out to be the most cytotoxic and displayed IC 50 values of 14.87 µM against A549 and 5.90 µM against HT-29 cell lines. In hyaluronidase inhibition assay, all compounds presented anti-inflammatory activity, however, slightly lower than reference compound. ADMET prediction showed that almost all compounds had good pharmacokinetic profiles. 1b, 1c and 1f compounds turned out to act against chemoresistance in cisplatin-resistant 253J B-V cells. Compounds intercalated into DNA and inhibited cell cycle in G0/G1 phase-the strongest inhibition was observed for 1i in A549 and 1c in HT-29. Among compounds, the highest apoptotic effect in both cell lines was observed after treatment with 1i. Compounds caused DNA damage and H2AX phosphorylation, which was detected in A549 and HT-29 cells. All research confirmed anticancer properties of novel tetrahydroacridine derivatives and explained a few pathways of their mechanism of cytotoxic action.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Novel tetrahydroacridine derivatives with iodobenzoic moieties induce G0/G1 cell cycle arrest and apoptosis in A549 non-small lung cancer and HT-29 colorectal cancer cells

et al. 2019

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“…At the same time, in order to obtain a pH response, h‐UCNP can be coated with pH responsive functional group to form with core‐ shell structure. As natural biopolymers, chitosan (CS) with biocompatibility and biodegradability is a suitable candidate for biomedical applications . Furthermore, chitosan has been reported to be used to enhance degradability, load drug, and improve pH‐responsive drug release efficiency.…”

Section: Introductionmentioning

confidence: 99%

“…As natural biopolymers, chitosan (CS) with biocompatibility and biodegradability is a suitable candidate for biomedical applications. [21,22] Furthermore, chitosan has been reported to be used to enhance degradability, load drug, and improve pH-responsive drug release efficiency. Therefore, the construction of a novel nanocarrier integrated with h-UCNP and CS can load two anticancer drugs at one time.…”

Section: Introductionmentioning

confidence: 99%

Construction of a Dual Drug Carrier on the Basis of Hollow Structured Upconversion Nanoparticles for pH‐Responsive Drug Delivery and UCL/MRI Dual Mode Imaging

Liu

Feng

et al. 2019

Part & Part Syst Charact

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A series of Gd3+ doping hollow upconversion nanoparticles NaYF4:Yb,Gd,Tm (h‐UNCP) are prepared successfully. The hollow NaYF4:Yb,Gd,Tm possess excellent upconversion luminescence (UCL) and large longitudinal relativity (r1 = 128.3 mm−1 s−1), which can be potentially used for UCL/magnetic resonance imaging (MRI) dual mode imaging. On the basis of the optimal h‐UCNP, doxorubicin hydrochloride (DOX) and methotrexate (MTX) are used as drug models to prepare a dual drug carrier. After the encapsulation of DOX on the h‐UCNP, chitosan (CS) is further wrapped and then used to load MTX to obtain a dual drug carrier h‐UCNPs/DOX/CS/MTX. The pH responsive release of DOX and MTX is discussed. The MTX release climbs from 33% to 100% by regulating the pH from 5.8 to 7.4. The DOX release is different at different pH conditions. The synergistic effect of DOX and MTX on the cancer cells is confirmed by cell viability. The h‐UCNPs/DOX/CS/MTX are tracked by cells UCL imaging and vivo MRI imaging. The excellent performance of UCL imaging and positive MRI images demonstrates that h‐UCNPs/DOX/CS/MTX can be used for UCL/MRI dual mode imaging. All the results show the potential application of h‐UCNPs/DOX/CS/MTX in pH responsive release and UCL/MRI dual imaging.

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A novel drug delivery system of mixed micelles based on poly(ethylene glycol)‐poly(lactide) and poly(ethylene glycol)‐poly(ɛ‐caprolactone) for gambogenic acid

Lin

Zhu

Yan

et al. 2019

The Kaohsiung J of Med Scie

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In this study, a novel mixed polymeric micelles formed from biocompatible polymers, poly(ethylene glycol)‐poly(lactide) (mPEG‐PLA) and poly(ethylene glycol)‐poly(ɛ‐caprolactone) (mPEG‐PCL), used as a novel nanocarrier to encapsulate gambogenic acid (GNA). GNA‐loaded mixed polymeric micelles (GNA‐MMs) was prepared by cosolvent evaporation method. The mean average size of GNA‐MMs was (83.23 ± 1.06) nm (n = 3) and entrapment efficiency (EE%) of GNA‐MMs was (90.18 ± 2.59) % (n = 3) as well as (12.36 ± 0.64) % (n = 3) for drug loading (DL%). Transmission electron microscopy revealed that the GNA‐MMs were spherical with “core‐shell” structures. Compared with free GNA solution, in vitro release of GNA from GNA‐MMs showed a two‐phase sustained release profile: an initial relatively fast phase and followed by a slower release phase. Pharmacokinetic results also indicated that the GNA‐MMs have longer systemic circulation time and slower plasma elimination rate than free GNA solution. Moreover, the in vitro cytotoxicity assay showed that the IC50 values on HepG2 cells for GNA‐MMs and free GNA were (5.67 ± 0.02) μM and (9.02 ± 0.03) μM, respectively. In addition, GNA‐MMs significantly increased the HepG2 cellular apoptosis in a concentration‐dependent manner. In conclusion, the results showed that mPEG‐PLA/mPEG‐PCL mixed micelles may serve as an ideal drug delivery system for GNA to prolong drug circulation time in body, enhance bioavailability and retained its potent antitumor effect.

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In vitro cytotoxicity study of dual drug loaded chitosan/palladium nanocomposite towards HT-29 cancer cells

Cited by 54 publications

References 56 publications

Novel tetrahydroacridine derivatives with iodobenzoic moieties induce G0/G1 cell cycle arrest and apoptosis in A549 non-small lung cancer and HT-29 colorectal cancer cells

Novel tetrahydroacridine derivatives with iodobenzoic moieties induce G0/G1 cell cycle arrest and apoptosis in A549 non-small lung cancer and HT-29 colorectal cancer cells

Construction of a Dual Drug Carrier on the Basis of Hollow Structured Upconversion Nanoparticles for pH‐Responsive Drug Delivery and UCL/MRI Dual Mode Imaging

A novel drug delivery system of mixed micelles based on poly(ethylene glycol)‐poly(lactide) and poly(ethylene glycol)‐poly(ɛ‐caprolactone) for gambogenic acid

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