In vitro cytotoxicity assessment of phthalocyanines on virus-transformed animal cells

Alexandrova, Radostina; Stoykova, Elena; Ion, Rodica‐Mariana; Nedkova, Kristina; Ivanova, Elena; Zdravkov, Kaloian; Minchev, Georgi

doi:10.1117/12.618977

Cited by 3 publications

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“…The spectral bands at 433 and 642 nm can be attributed to the diprotonated ionic species H 4 TPPS 4 2-, whereas the band at 490nm (B-band) and at 707nm (Q-band) are characteristic for J-aggregates [10]. A further decrease of the solution pH to 1.2 results in an increase in the intensity of the absorption bands at 490 and 706 nm, and in the disappearance of the absorption bands related to the neutral and diprotonated species of porphyrin H 2 TPPS 4 4- [15][16][17][18]. These changes in the absorption spectra have been assigned to the formation of the J-aggregates, derived from the dianionic H 4 TPPS 4 2-, as indicated by the diminution of the absorption at 433 nm [19], with a heliptic structure, as have already been reported, (fig.…”

Section: Resultsmentioning

confidence: 99%

Porphyrin - Based Supramolecular Nanotubes Generated by Aggregation Processes

Ion¹,

Boda²

2008

Rev. Chim.

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Porphyrins can form a variety of structures from linear head-to-tail or J-aggregates to fractal aggregates with different and specific photophysical properties. In this paper, the controlled aggregation of meso-5 ,10, 15, 20-sulfonato-phenyl porphyrin (H2TPPS44-) was studied at room temperature. Structure of the aggregates was characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM) and UV-visible spectroscopy. TEM and SEM results indicated the formation of organized nanostructures from the porphyrin derivative. UV-visible-NIR spectroscopic data showed broad red-shifted Soret band, indicating J-aggregation among the monomer units. Conjugate effect of lateral p-p interaction among the tetrapyrrole cores and hydrophobic interaction among the peripheral phenyl rings is believed to lead to the organized nanostructures. Such aggregates have the size of 5-6 nm in solution. The columnar structure formed by porphyrins has a length of 5 to 27 porphyrin unities.

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Section: Resultsmentioning

confidence: 99%