In Vitro Cytophysiological Aspects Induced by Food Additives From the Category of Preservatives on Some Mammalian Cell Models
Daniela Gherghel,
Cosmin-Teodor Mihai,
Gabriela Vochita
et al.
Abstract:This research is focused on cellular response to sodium metabisulphite (E223), sodium benzoate (E211), and sodium nitrite (E250) application on two normal mammalian cells, namely MCF-12A (ATCC CRL-3598) and Vero (ATCC CCL-81). The monitored parameters were cell viability (MTT assay), cell morphology (optical microscopy) and cell survival (clonogenic assay). The treatment was applied in doses of 12.5; 25; 50 and 100 µg/mL. According to all tests assessed, our results proved a dose-response relationship, the mos… Show more
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