In vitro culture studies of Sutherlandia frutescens on human tumor cell lines

The influence of Sutherlandia frutescens on adrenal steroidogenic cytochrome P450 enzymes

“…The extraction yielded 154 and 289 mg extract/g dried plant material for the methanol and aqueous extraction, respectively. The two components, identified by Tai et al (2004), with molecular weights of 740 (m/z 739.1, peaks at 5.38 min and 5.57 min) and 724 (m/z, 723.1, peaks at 5.89 min and 6.03 min), were confirmed by negative ion electrospray mass spectrometry (Fig. 1).…”

Evaluation of the mutagenic and antimutagenic effects of South African plants

“…A toxicity study has been performed using 16 Vervet monkeys, where consumption of leaf powder did not exhibit any toxic or side effects (Final report by the Medical Research Council, South Africa, 2002;Fernandes et al, 2004). Chemical studies have identified one compound, canavanine, a non-protein ␣-amino acid with anti-tumor properties (Bell et al, 1978;Tai et al, 2004). Its major metabolite, canaline is being developed as a new anticancer drug, for pancreatic cancer (Crooks and Rosenthal, 1994).…”

“…Extracts of Sutherlandia frutescens have been shown to exhibit anti-inflammatory activity in the COX-2 assay (Kundu et al, 2004) with mention made that anti-inflammatory activity may be related to anticarcinogenic activity. Ethanol extracts have been shown to indicate a concentration dependent antiproliferative effect on several human tumor cell lines (MDA-MB 468 breast cancer cells and HL60 Leukemia cells) (Tai et al, 2004). Sutherlandia frutescens has received international attention as a cheap herbal medicine that can improve the health of AIDs patients (Harnett et al, 2005).…”

HPLC and GC analyses of in vitro-grown leaves of the cancer bush Lessertia (Sutherlandia) frutescens L. reveal higher yields of bioactive compounds

“…Numerous reports document the anti-oxidant (Tai et al 2004), stress-relieving (Prevoo et al 2008), hypoglycaemic (Chadwick et al 2007), anti-mutagenic (Reid et al 2006), and anti-tumour (Stander et al 2007) properties of extracts of L. frutescens. Extracts are also reported to inhibit the action of HIV target enzymes (Hartnett et al 2005).…”