in vitro cortisol biosynthesis by a testicular tumor

Besch, Paige K.; Watson, David J.; Barry, Roger D.; Hamwi, George J.; Mostow, Jack H.; Gwinup, Grant

doi:10.1016/s0039-128x(63)80098-7

Cited by 10 publications

(1 citation statement)

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“…These patients show evidence of prolonged increased ACTH secretion; their testicular tumours have been shown to be ACTH-dependent (Prader 1953;Hedinger 1954;Glenn 8c Boyce 1962;Gardner et al 1950;Wilkins 1957), and in the case studied by us (Schoen et al 1961) the in vitro steroidogenic activity of the testicular tumours resembled that of abnormal adrenocortical tissue (Domínguez 1961). That testicular tumours can arise from ectopie adrenocortical cells in patients other than boys with con¬ genital adrenocortical hyperplasia is indicated by the finding of Hamwi et al (1963) and Besch et al (1963), that a testicular tumour which arose in a patient with elevated plasma ACTH levels and Cushing's syndrome produced steroids (mainly cortisol and cortisone) in vitro that were identical with those produced by normal adrenal tissue. Other cases of in vitro production of cortisol by testicular tumours have been reported by Besch et al (1964), Engel et al (1964.…”

Section: Discussionmentioning

confidence: 99%

Testicular Androgen Biosynthesis Following Corticotrophin and Human Chorionic Gonadotrophin Administration

Schoen

Samuels

1965

Acta Endocrinologica

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The effects of in vivo administration of corticotrophin (ACTH) and human chorionic gonadotrophin (HCG) on rat testes were studied. HCG, administered for 14 days to young rats, led to testicular interstitial cell hypertrophy and hyperplasia, accompanied by stimulation of in vitro testicular androgen production, as manifested by increased 17\g=a\-hydroxylase and 17\g=b\-desmolaseenzyme activities, with no clear-cut effect on 20\ g=a\ \ x=r eq-\ hydroxysteroid dehydrogenase activity. The findings in ACTH-treated animals were similar to those in the saline-treated controls. The lack of influence of ACTH on the testicular enzymes involved in steroid biosynthesis is consonant with the concept that ACTH-dependent bilateral testicular tumours occurring in boys with congenital adrenocortical hyperplasia arise from [00BB]adrenocorticalrest cells[00AB]rather than from testicular interstitial cells.Bilateral steroid-secreting testicular tumours occurring in a boy with the saltlosing form of congenital adrenocortical hyperplasia (Schoen et al. 1961) aroused our interest in the mechanism of formation of such tumours. Results of in vitro studies of steroid biosynthesis in these tumours favoured the theory that the tissue of origin was abnormal »adrenocortical rest cells« in the testes rather than testicular interstitial cells (Domínguez 1961).

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