In vitro comparison of four treatments which discourage infestation by head lice

Greive, Kerryn A; Barnes, Tanya M

doi:10.1007/s00436-011-2687-7

Cited by 10 publications

(7 citation statements)

References 22 publications

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“…In Egypt, head lice infestation is an important public health problem and about 22% of school students in a study carried out in Cairo was lice-infested [ 2 ]. The global control of pediculosis has been hampered as a result of incorrect use of topical insecticides, and the increasing resistance to the commonly used pediculicides, including lindane, malathion, and permethrin [ 3 ]. Therefore, there is an urgent need for the development of new effective pediculicidal products for the market.…”

Section: Introductionmentioning

confidence: 99%

Electron Microscopic Alterations in Pediculus humanus capitis Exposed to Some Pediculicidal Plant Extracts

et al. 2016

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Head lice, Pediculus humanus capitis, infestation is an important public health problem in Egypt. Inadequate application of topical pediculicides and the increasing resistance to the commonly used pediculicides made the urgent need for the development of new agents able to induce irreversible changes in the exposed lice leading to their mortality. The aim of the present work is to evaluate pediculicidal efficacy of some natural products such as olive oil, tea tree oil, lemon juice, and ivermectin separately in comparison with tetramethrin-piperonyl butoxide (licid), as a standard pediculicide commonly used in Egypt. The effects of these products were evaluated by direct observation using dissecting and scanning electron microscopes (SEM). Results showed that after 1 hr exposure time in vitro, absolute (100%) mortalities were recorded after exposure to 1% ivermectin and fresh concentrate lemon juice. The mortalities were decreased to 96.7% after exposure to tea tree oil. Very low percentage of mortality (23.3%) was recorded after 1 hr of exposure to extra virgin olive oil. On the other hand, the reference pediculicide (licid) revealed only mortality rate of 93.3%. On the contrary, no mortalities were recorded in the control group exposed to distilled water. By SEM examination, control lice preserved outer smooth architecture, eyes, antenna, respiratory spiracles, sensory hairs, and legs with hook-like claws. In contrast, dead lice which had been exposed to pediculicidal products showed damage of outer smooth architecture, sensory hairs, respiratory spiracles and/or clinching claws according to pediculicidal products used.

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Section: Introductionmentioning

confidence: 99%

Electron Microscopic Alterations in Pediculus humanus capitis Exposed to Some Pediculicidal Plant Extracts

et al. 2016

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“…Head lice are common among children aged 3–11 years, which can be transmitted through either direct (head-to-head) contact with the infested person or indirectly through personal items, such as combs, hats, scarfs, beddings and towels [ 5 ]. Pediculosis capitis presents a public health problem [ 6 ] as it can cause social stigma, embarrassment, low self-esteem, loss of productivity, and frustration among afflicted individuals [ 7 ]. It is not generally associated with morbidity [ 7 ] and is not currently considered to be vectors for human pathogens [ 8 ], but secondary bacterial infections may occur as a result of subsequent skin excoriation due to sensitization to louse saliva [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…These includes permethrin, pyrethrin, malathion, and lindane. However, their use to control pediculosis globally has been hampered due to the growing issues concerning the aforementioned treatments [ 7 ]. There have been records of resistance in many parts of the world due to a large treatment selection pressure induced by conventional pediculicides.…”

Section: Introductionmentioning

confidence: 99%

Safety, Efficacy, and Physicochemical Characterization of Tinospora crispa Ointment: A Community-Based Formulation against Pediculus humanus capitis

et al. 2017

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The high prevalence of pediculosis capitis, commonly known as head lice (Pediculus humanus capitis) infestation, has led to the preparation of a community-based pediculicidal ointment, which is made of common household items and the extract of Tinospora crispa stem. The present study aimed to evaluate the safety, efficacy, and physicochemical characteristics of the T. crispa pediculicidal ointment. The physicochemical properties of the ointment were characterized, and safety was determined using acute dermal irritation test (OECD 404), while the efficacy was assessed using an in vitro pediculicidal assay. Furthermore, the chemical compounds present in T. crispa were identified using liquid-liquid extraction followed by ultra-performance liquid chromatography quadruple time-of-flight mass spectrometric (UPLC-qTOF/MS) analysis. The community-based ointment formulation was light yellow in color, homogeneous, smooth, with distinct aromatic odor and pH of 6.92±0.09. It has spreadability value of 15.04±0.98 g·cm/sec and has thixotropic behavior. It was also found to be non-irritant, with a primary irritation index value of 0.15. Moreover, it was comparable to the pediculicidal activity of the positive control Kwell®, a commercially available 1% permethrin shampoo (P>0.05), and was significantly different to the activity of the negative control ointment, a mixture of palm oil and candle wax (P<0.05). These findings suggested that the community-based T. crispa pediculicidal ointment is safe and effective, having acceptable physicochemical characteristics. Its activity can be attributed to the presence of compounds moupinamide and physalin I.

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“…Pediculosis, commonly referred to as head lice (Pediculus humanus capitis) infestation is common and endemic worldwide, and affects persons of all socioeconomic backgrounds and ages (Greive and Barnes, 2012). It is a prevalent and contagious condition afflicting mostly children between three to ten years old (Samuel et al 2009).…”

Section: Introductionmentioning

confidence: 99%

“…It usually affects school-age children and can be transmitted through direct head-tohead contact. It is not generally associated with morbidity apart from secondary bacterial infections but they may cause social stigma, embarrassment, low self-esteem, lost productivity and frustration among all involved (Greive and Barnes, 2012).…”

Section: Introductionmentioning

confidence: 99%

Formulation of pediculicidal hair cream from the petroleum ether leaf extract of Millettia pinnata (L.) Panigrahi (Fam. Fabaceae)

Sayson¹,

Gaffud²,

Pangilinan³

et al. 2017

Pharm Sci Asia

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Pediculosis, commonly referred to as head louse (Pediculus humanus capitis) infestation, is common and endemic worldwide. However, exposure to the current standard treatment such as permethrin and pyrethrin can cause neurotoxicity especially when misused and resistance to these chemicals has been a concern. This study aimed to develop a pediculicidal hair cream using the petroleum ether leaf extract of Millettia pinnata to address the problems associated with head louse infestation by providing and developing a better and safer alternative pediculicide. This study involved the formulation of an acceptable hair cream and the evaluation of pediculicidal activity of different treatments using filter paper diffusion method. Permethrin (Kwell ® ), the positive control, had the greatest anti-lice activity of all the treatments. In the determination of minimum effective concentration, only 80% bani hair cream was found to be effective. However, the 5% bani hair cream was selected as the final formulation based on both efficacy and quality. The final formulation exhibited greater pediculicidal activity than the commercially available herbal pediculicide, quassinoids (Oilganics ® ), and the 60% makabuhay hair cream formulation. Replicate observations should be performed to determine any significant difference among the different treatments.

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In vitro comparison of four treatments which discourage infestation by head lice

Cited by 10 publications

References 22 publications

Electron Microscopic Alterations in Pediculus humanus capitis Exposed to Some Pediculicidal Plant Extracts

Electron Microscopic Alterations in Pediculus humanus capitis Exposed to Some Pediculicidal Plant Extracts

Safety, Efficacy, and Physicochemical Characterization of Tinospora crispa Ointment: A Community-Based Formulation against Pediculus humanus capitis

Formulation of pediculicidal hair cream from the petroleum ether leaf extract of Millettia pinnata (L.) Panigrahi (Fam. Fabaceae)

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