In vitro characterization of virulence factors among species of the Candida parapsilosis complex

Ataídes, Fábio Silvestre; Costa, Carolina Rodrigues; Santos, Andressa Santana; Freitas, Vivianny Aparecida Queiroz; Silva, Thaísa Cristina; Zara, Ana Laura Sene Amâncio; Jesuino, Rosália Santos Amorim; Silva, Maria Rosário Rodrigues

doi:10.1590/0037-8682-0336-2019

Cited by 3 publications

(4 citation statements)

References 14 publications

(23 reference statements)

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“…With the advent of genetic analyses, sample species believed to be a single species became distinct species with different levels of drug resistance. This is the case of Candida parapsilosis, reclassified into three species: C. parapsilosis senso stricto, C. orthopsilosis and C. metapsilosis [98].…”

Section: Candida Auris: the Mysterious Fungal Infection Adapted To Global Warmingmentioning

confidence: 99%

The Rise of Fungi: Evidence on the Global Scale. Old Known Silences or Mysterious Threats to the Planet

Júnior

Costa

Dantas

et al. 2020

MRJI

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Introduction: Fungi are organisms that present themselves in multicellular macroscopic and unicellular microscopic forms. They are eukaryotic, heterotrophic, reproduce asexually/sexually, cosmopolitan, achlorophyllates and are present in various climatic conditions and found in a variety of species and forms in nature. Aims: Present the emerging evolution of fungi, their underreporting, scale and parameters that show their potential as a heterotrophic organism, decomposer and pathogen. Methodology: In this review, we conducted a search emphasizing themes about fungi using the available databases and based on the scientific literature, we discussed a series of recent issues involving this wide realm and the constant controversies and expectations that guide the existence of fungi on the planet. Results: The results presented show an analysis of the action of these eukaryotic organisms and their interaction with other living beings, the constant changes in taxonomy, their pathogenic potential in plants and animals, issues related to the intrinsic resistance of some species to drugs and also the potential biotechnological for which these organisms demonstrate high plasticity. Conclusion: The expansion of fungal diseases to the fauna and flora of the planet; leads us to believe that, unless measures are taken to reinforce biosafety issues, it will be increasingly necessary to take care of the health conditions of the planet to avoid a global collapse caused by microscopic beings.

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Section: Candida Auris: the Mysterious Fungal Infection Adapted To Global Warmingmentioning

confidence: 99%

The Rise of Fungi: Evidence on the Global Scale. Old Known Silences or Mysterious Threats to the Planet

Júnior

Costa

Dantas

et al. 2020

MRJI

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“…Três inóculos de 10 µL de diluição da colônia em salina estéril (Escala 4 de McFarland) foram depositados em três pontos distintos da placa de Petri (15x90 mm). As placas permaneceram incubadas a 32 °C por 14 dias (Aoki et al, 1994;Ataides et al, 2020).…”

Section: Proteaseunclassified

“…Para a avaliação da atividade hemolítica das leveduras, foi utilizada a técnica proposta por Ataides et al (2020). Inicialmente, as colônias foram cultivadas por 3 dias em agar Sabouraud dextrose a 37 °C.…”

Section: Atividade Hemolíticaunclassified

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Identificação fenotípica e proteômica da micobiota oral de cães sensibilidade a antifúngicos e virulência

Bonci¹

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In vitro activity of sanitizers against mono- and polymicrobial biofilms of C. parapsilosis and S. aureus

Castro,

Thomaz,

Vieira

et al. 2023

Antimicrob Agents Chemother

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The emergence of disinfectant-resistant microorganisms poses a significant threat to public health. These resilient pathogens can survive and thrive in hospital settings despite routine disinfection practices, leading to persistent infections and the potential for outbreaks. In this study, we investigated the impact of 11 different commercial sanitizers at various concentrations and exposure times on biofilms consisting of clinical and nosocomial environmental isolates of Candida parapsilosis and Staphylococcus aureus . Among the sanitizers tested, 0.5% and 2.0% chlorhexidine (CLX), 10% polyvinyl pyrrolidone (PVP-I), a disinfectant based on quaternary ammonium compound (QAC), 2% glutaraldehyde, and 0.55% orthophthalaldehyde (OPA) demonstrated efficacy against both C. parapsilosis and S. aureus in monospecies and mixed biofilms. Analysis showed that 0.5% CLX and 10% PVP-I had fungicidal and bactericidal activity against all biofilms. However, the sanitizer based on QAC and 0.55% OPA proved to be bacteriostatic and fungicidal against both monospecies and mixed biofilms. In mixed biofilms, despite the last four sanitizers exerting fungicidal action, the reduction of fungal cells was approximately 4 log 10 CFU/mL compared to monospecies biofilms, showing that the interaction provided more resistance of the yeast to the sanitizer. Formation of mixed biofilms in hospital settings can create an ecological niche that enhances the survival of pathogens against routine sanitization procedures. Therefore, effective sanitization practices, including regular cleaning with effective sanitizers, should be implemented to prevent C. parapsilosis/S. aureus biofilm formation in healthcare settings.

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In vitro characterization of virulence factors among species of the Candida parapsilosis complex

Cited by 3 publications

References 14 publications

The Rise of Fungi: Evidence on the Global Scale. Old Known Silences or Mysterious Threats to the Planet

The Rise of Fungi: Evidence on the Global Scale. Old Known Silences or Mysterious Threats to the Planet

Identificação fenotípica e proteômica da micobiota oral de cães sensibilidade a antifúngicos e virulência

In vitro activity of sanitizers against mono- and polymicrobial biofilms of C. parapsilosis and S. aureus

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