In-vitro characterization of stress corrosion cracking of aluminium-free magnesium alloys for temporary bio-implant applications

Choudhary, Lokesh; Raman, R.K. Singh; Hofstetter, Joëlle; Uggowitzer, Peter J.

doi:10.1016/j.msec.2014.06.018

Cited by 95 publications

(48 citation statements)

References 51 publications

(72 reference statements)

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“…As a result, at the conclusion of the 16w implantation, minor localized corrosion was observed on the surface of the J1 alloy (Fig. 5A), which is an important aspect to help reduce possible structural failures in clinical applications [49]. Structural failures induced by high corrosion rate may result in loss of mechanical integrity of the implant, which is also the primary limitation of Mg alloy implants used in the load bearing application [50].…”

Section: Discussionmentioning

confidence: 99%

An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg–1Sr alloy

et al. 2016

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An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg-1Sr alloyIn: Acta Biomaterialia (2015) Elsevier DOI: 10.1016DOI: 10. /j.actbio.2015 An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg-1Sr alloy AbstractPrevious studies indicated that local delivery of strontium effectively increased bone quality and formation around osseointegrating implants. Therefore, implant materials with long-lasting and controllable strontium release are avidly pursued. The central objective of the present study was to investigate the in vivo biocompatibility, metabolism and osteogenic activity of the bioabsorbable Mg-1Sr (wt.%, nominal composition) alloy for bone regeneration. The general corrosion rate of the alloy implant as a femoral fracture fixation device was 0.55 ± 0.03 mm y −1 (mean value ± standard deviation) in New Zealand White rabbits which meet the bone implantation requirements and can be adjusted by material processing methods. All rabbits survived and the histological evaluation showed no abnormal physiology or diseases 16 weeks post-implantation. The degradation process of the alloy did not significantly alter 16 primary indexes of hematology, cardiac damage, inflammation, hepatic functions and metabolic process. Significant increases in peri-implant bone volume and direct bone-toimplant contact (48.3% ± 15.3% and 15.9% ± 5.6%, respectively) as well as the expressions of four osteogenesis related genes (runt-related transcription factor 2, alkaline phosphatase, osteocalcin, and collagen, type I, alpha 1) were observed after 16 weeks implantation for the Mg-1Sr group when compared to the pure Mg group. The sound osteogenic properties of the Mg-1Sr alloy by longlasting and controllable Sr release suggesting a very attractive clinical potential. Statement of significanceSr (strontium) has exhibited pronounced effects to reduce the bone fracture risk in osteoporotic patients. Nonetheless, long-lasting local Sr release is hardly achieved by traditional methods like surface treatment. Therefore, a more efficient Sr local delivery platform is in high clinical demand. The stable and adjustable degradation process of Mg alloy makes it an ideal Sr delivery platform. We combine the well-known osteogenic properties of strontium with magnesium to manufacture bioabsorbable Mg-1Sr alloy with stable Sr release based on our previous studies. The in vitro and in vivo results both showed the alloy's suitable degradation rate and biocompatibility, and the sound osteogenic properties and stimulation effect on bone formation suggest its very attractive clinical potential.

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Section: Discussionmentioning

confidence: 99%

An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg–1Sr alloy

et al. 2016

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“…SCC susceptibility was reported to increase with Zn content [22], although this was disputed by Fairman and Bary [23]. SCC is known to occur in the commercial Mg-Zn alloys ZK60 (6%Zn, <1%Zr) and ZE10 (1%Zn, <1% rare earths) [17] and Choudhary et al [24] found SCC in ZX50 (5%Zn, 0.25%Ca) and WZ21 (2%Y1%Zn) in a synthetic body fluid. Bobby Kannan et al [25] found that ZE41…”

Section: Introductionmentioning

confidence: 99%

Corrosion and stress corrosion cracking of ultra-high-purity Mg5Zn

et al. 2015

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This paper reports on the measurement of the corrosion rate, and the stress corrosion cracking threshold stress, for ultra-high-purity Mg-5Zn. The corrosion rate was higher than the intrinsic corrosion rate of ultra-high-purity Mg, attributed to the quality of the corrosion product film. The threshold stress for stress corrosion cracking, at an applied stress rate of 0.00016 MPa s -1 , was equal to 0.7 times the yield stress in air. The ductility of the cracking indicated that the stress corrosion cracking mechanism was probably hydrogen enhanced localized plasticity.

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“…The nominal chemical composition (in wt %) is Zn 1%, Ca 0.25%, Mn 0.15% and Y 2% [39]. Coupons of magnesium alloy WZ21 were ground with SiC papers down to 2500 grit size, ultrasonically cleaned with acetone and ethanol (10 min for each step), rinsed with DI water, and dried using compressed air.…”

Section: Sample Preparation and Coating Proceduresmentioning

confidence: 99%

Hexagonal Boron Nitride Impregnated Silane Composite Coating for Corrosion Resistance of Magnesium Alloys for Temporary Bioimplant Applications

Al-Saadi

Banerjee

Anisur

et al. 2017

Metals

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Magnesium and its alloys are attractive potential materials for construction of biodegradable temporary implant devices. However, their rapid degradation in human body fluid before the desired service life is reached necessitate the application of suitable coatings. To this end, WZ21 magnesium alloy surface was modified by hexagonal boron nitride (hBN)-impregnated silane coating. The coating was chemically characterised by Raman spectroscopy. Potentiodynamic polarisation and electrochemical impedance spectroscopy (EIS) of the coated alloy in Hanks' solution showed a five-fold improvement in the corrosion resistance of the alloy due to the composite coating. Post-corrosion analyses corroborated the electrochemical data and provided a mechanistic insight of the improvement provided by the composite coating.

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In-vitro characterization of stress corrosion cracking of aluminium-free magnesium alloys for temporary bio-implant applications

Cited by 95 publications

References 51 publications

An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg–1Sr alloy

An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg–1Sr alloy

Corrosion and stress corrosion cracking of ultra-high-purity Mg5Zn

Hexagonal Boron Nitride Impregnated Silane Composite Coating for Corrosion Resistance of Magnesium Alloys for Temporary Bioimplant Applications

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