In Vitro Characterization of Doped Bioglass 45S5/HAp Coatings Obtained by CoBlastTM Deposition

Abstract

Bone replacement is one of the major medical procedures in the oral surgery field due to the progressive ageing population and to illness or trauma in younger age groups. The use of implants without biological activity and effective osseointegration increases the chances of implant failure. This work aims to improve the interaction between implants and bone by using Bioglass 45S5 (BG)/hydroxyapatite (HAp) mixtures, including copper-, zinc-, and cerium-doped BG, as well as co-doping by the mentioned metals, as coatings produced by the CoBlastTM technique. All coatings present a uniform coverage of the Ti-6Al-4V substrate. Furthermore, in vitro testing using human osteosarcoma Saos-2 cells indicated that BG/HAp coatings have no cytotoxic effect, and the used of doping agents did not alter cell adhesion, proliferation, or alkaline phosphatase (ALP) expression when compared to undoped coating. These results demonstrate that BG/HAp by CoBlastTM can be a solution to improve implants’ osseointegration.

Exploring the Impact of Copper Oxide Substitution on Structure, Morphology, Bioactivity, and Electrical Properties of 45S5 Bioglass®

“…The choice of the material and antibacterial agent is crucial to guarantee both an effective action against microorganisms and harmlessness to the human body, and in the best case, favorable biological activity (osteoconduction, osteointegration, etc.) [18][19][20].…”

Influence of the Addition of Zinc, Strontium, or Magnesium Oxides to the Bioglass 45S5 Network on Electrical Behavior

“…Weak bone regeneration and the risk of instability during the healing phase have been recognized as significant challenges in the field of implantology [1][2][3]. Surface treatments that improve surface roughness have been an important strategy for increasing osseointegration, allowing for a stronger bond between the implant and the surrounding bone tissue [4][5][6]. However, this strategy may not be sufficient to assure long-term implant success, especially in situations where inflammatory reactions can result in bone support loss and implant failure [7,8].…”

The Effect of Iron Oxide Insertion on the In Vitro Bioactivity, and Antibacterial Properties of the 45S5 Bioactive Glass

“…However, recent findings emphasize the need to integrate biocompatibility, osseointegration, tissue regeneration, and other biological factors as fundamental components of successful implant design [ 3 , 4 ]. The realization that clinical outcomes are intricately linked to the interaction of the implant with the biological fluid has prompted advancements in materials and surface modifications [ 5 , 6 , 7 , 8 ]. In recent years, there has been a growing interest in coating implants with bioactive materials to enhance biological performance including biocompatibility, osseointegration, and tissue regeneration, therefore ensuring enhanced longevity, stability, and overall success in clinical applications [ 7 , 9 , 10 ].…”