In vitro characterization of design and compressive properties of 3D-biofabricated/decellularized hybrid grafts for tracheal tissue engineering

Tissue Engineering and its Appllication Areas

“…tarafından 3 boyutlu PCL iskele ve domuz kökenli deselülerize trakea yapıları hibrid olarak sentezlenmiştir ve elde edilen yapının doku mühendisliği alanında kullanılabileceği gös-terilmiştir. 26 Trakea transplantasyonunu hedefleyen deselülerize yapılarda immün yanıtın en az seviyede oluşması, yapıların hızlı vaskülerize olması, sağlıklı bir solunum için epitelyal tabaka büyümesinin desteklenmesi ve doğal trakea yapısının mekanik özel-liklerinin sürdürülebilmesi önemlidir. Belirtilen bu hususlara bağlı olarak 2017 yılında, Den Hondt ve ark.…”

Rising influence of synthetic biology in regenerative medicine

“…This structure was obtained within three weeks as opposed to the typical three months, thereby allowing the development of clinically functioning, fully in vivo tissue engineered airway replacements that can be obtained within a clinically useful time [23,46]. In saying this, research is still underway to develop improved human tissue structures through the use of novel state-of-the art technologies and methods, for instance three-dimensional (3D) printing, 3D-biofabrication approaches (a combination of 3D-bioplotting and thermally-assisted forming) [47,48], and the generation of orgainoids by bioreactor-assisted self-assembly methods [49].…”

Selection of the optimum 3D‐printed pore and the surface modification techniques for tissue engineering tracheal scaffold in vivo reconstruction

“…According to the individual design specifications, it processes the printing material layer by layer to build a bionic construction . Researchers built a variety of tracheal scaffolds based on PCL using 3D print such as patch, ring, hollow bellows or hybrid . Similar studies and clinical reports demonstrated good prospects for PTS reconstruction.…”