In Vitro Characteristics of Porcine Tendon Hydrogel for Tendon Regeneration

Crowe, Christopher S.; Chiou, Grace; McGoldrick, Rory; Hui, Kenneth; Pham, Hung; Hollenbeck, Emily

doi:10.1097/sap.0000000000000361

Cited by 10 publications

(7 citation statements)

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“…While there were promising initial ex vivo functional studies with human tendon sources, others looked to transition to more commercially sustainable sources, including porcine [83] and equine [41]. Crowe et al .…”

Section: Musculoskeletal Tissuesmentioning

confidence: 99%

“…Source species can be xenogeneic, typically from porcine or bovine sources, allogeneic from cadaveric donor tissue sources, or autologous in rare cases. A few studies directly compared porcine and human sources [68, 74, 83]. It was shown that human myocardial sources had decreased mechanical stiffness compared to porcine [68].…”

Section: Translational Considerationsmentioning

confidence: 99%

“…It was shown that human myocardial sources had decreased mechanical stiffness compared to porcine [68]. However, for tendon, human-derived hydrogels were mechanically stronger than porcine sources [83]. There are possibilities for autologous tissue sourcing, as demonstrated with the pericardium [74] and omentum [118]-based tissue sources, but these sources require invasive surgeries and delayed processing time with an inability to be off-the-shelf.…”

Section: Translational Considerationsmentioning

confidence: 99%

“…Many ECM sheet products (AlloDerm, Lifecell Corp.) and injectable ground ECM products (ACell's Cytal™ Wound Matrix, MicroMatrix ® , CorMatrix ® ) have reached commercialization, and injectable ECM hydrogels may soon follow this trend, with one product reaching clinical trials. In parallel, work has shown that digested ECM and hydrogels can be lyophilized and stored for long-term use [83, 84], supporting future translation and commercialization efforts. Trends have emerged regarding tissue sources, as the species [68], age [64, 121], and specificity [130] can not only impact the performance of an ECM hydrogel, but can have strong implications concerning scalability, a current challenge in the tissue engineering industry.…”

Section: Future Outlook On Ecm Hydrogelsmentioning

confidence: 99%

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Extracellular matrix hydrogel therapies: In vivo applications and development

2018

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Section: Musculoskeletal Tissuesmentioning

confidence: 99%

Section: Translational Considerationsmentioning

confidence: 99%

Section: Translational Considerationsmentioning

confidence: 99%

Section: Future Outlook On Ecm Hydrogelsmentioning

confidence: 99%

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Extracellular matrix hydrogel therapies: In vivo applications and development

2018

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“…Finally, moral and religious objections could be raised to the use of (decellularized) human tissues, especially cadaveric tissues, as scaffold components. Synthetic scaffolds, 97 animal-derived scaffolds, 72 , 98 or (decellularized) tissues from living donors 99 , 100 would therefore be preferred.…”

Section: Resultsmentioning

confidence: 99%

The Ethical Implications of Tissue Engineering for Regenerative Purposes: A Systematic Review

Kanter

Jongsma

Verhaar

et al. 2023

Tissue Engineering Part B: Reviews

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Tissue Engineering (TE) is a branch of Regenerative Medicine (RM) that combines stem cells and biomaterial scaffolds to create living tissue constructs to restore patients' organs after injury or disease. Over the last decade, emerging technologies such as 3D bioprinting, biofabrication, supramolecular materials, induced pluripotent stem cells, and organoids have entered the field. While this rapidly evolving field is expected to have great therapeutic potential, its development from bench to bedside presents several ethical and societal challenges. To make sure TE will reach its ultimate goal of improving patient welfare, these challenges should be mapped out and evaluated. Therefore, we performed a systematic review of the ethical implications of the development and application of TE for regenerative purposes, as mentioned in the academic literature. A search query in PubMed, Embase, Scopus, and PhilPapers yielded 2451 unique articles. After systematic screening, 237 relevant ethical and biomedical articles published between 2008 and 2021 were included in our review. We identified a broad range of ethical implications that could be categorized under 10 themes. Seven themes trace the development from bench to bedside: (1) animal experimentation, (2) handling human tissue, (3) informed consent, (4) therapeutic potential, (5) risk and safety, (6) clinical translation, and (7) societal impact. Three themes represent ethical safeguards relevant to all developmental phases: (8) scientific integrity, (9) regulation, and (10) patient and public involvement. This review reveals that since 2008 a significant body of literature has emerged on how to design clinical trials for TE in a responsible manner. However, several topics remain in need of more attention. These include the acceptability of alternative translational pathways outside clinical trials, soft impacts on society and questions of ownership over engineered tissues. Overall, this overview of the ethical and societal implications of the field will help promote responsible development of new interventions in TE and RM. It can also serve as a valuable resource and educational tool for scientists, engineers, and clinicians in the field by providing an overview of the ethical considerations relevant to their work. Impact statement To our knowledge, this is the first time that the ethical implications of Tissue Engineering (TE) have been reviewed systematically. By gathering existing scholarly work and identifying knowledge gaps, this review facilitates further research into the ethical and societal implications of TE and Regenerative Medicine (RM) and other emerging biomedical technologies. Moreover, it will serve as a valuable resource and educational tool for scientists, engineers, and clinicians in the field by providing an overview of the ethical considerations relevant to their work. As such, our review may promote successful and responsible development of new strategies in TE and RM.

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A Review of Decellularized Extracellular Matrix Biomaterials for Regenerative Engineering Applications

Heath

2019

Regen. Eng. Transl. Med.

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In Vitro Characteristics of Porcine Tendon Hydrogel for Tendon Regeneration

Abstract: After reconstitution and digestion, porcine hydrogel was capable of supporting growth of human ASCs. The minimal difference in proliferative capacity suggests that porcine tendon hydrogel may be an effective and viable alternative to human hydrogel for the enhancement of tendon healing.

Cited by 10 publications

References 50 publications

Extracellular matrix hydrogel therapies: In vivo applications and development

Extracellular matrix hydrogel therapies: In vivo applications and development

The Ethical Implications of Tissue Engineering for Regenerative Purposes: A Systematic Review

A Review of Decellularized Extracellular Matrix Biomaterials for Regenerative Engineering Applications

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