In-vitro catalytic, antimicrobial and antioxidant activities of bioengineered copper quantum dots using Mangifera indica (L.) leaf extract

Rani, Humaira; Singh, Satarudra Prakash; Yadav, Thakur Prasad; Khan, Mohd Sajid; Ansari, Mohammad Israil; Singh, Akhilesh Kumar

doi:10.1016/j.matchemphys.2019.122052

Cited by 46 publications

(17 citation statements)

References 60 publications

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“…The applicative significance of the copper–polysaccharide interaction lies in the fact that microorganisms are extremely susceptible to copper, while copper is considered to be safe for external application on human skin, with a very low risk of adverse reactions . Indeed, numerous investigations have been conducted regarding the possible use of copper as an antimicrobial agent. − , These studies have shown that the bacterial toxicity of copper may be due to the displacement of essential metals from their native binding sites, interference with oxidative phosphorylation and the osmotic balance, and alterations of the conformational structure of nucleic acids, membranes, and proteins . In microorganisms, including microalgae, metals can cause the formation of reactive oxygen species that interact with lipids, proteins, and nucleic acids, resulting in their degradation.…”

Section: Introductionmentioning

confidence: 99%

Red Microalgal Sulfated Polysaccharide–Cu₂O Complexes: Characterization and Bioactivity

Yehuda

Shalish

Kushmaro

et al. 2021

ACS Appl. Mater. Interfaces

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The anion-exchange capacity of the cell-wall sulfated polysaccharide of the red microalga Porphyridium sp. can be exploited for the complexation of metal ions (e.g., Cu, Zn, Ag) to produce novel materials with new bioactivities. In this study, we investigated this algal polysaccharide as a platform for the incorporation of copper as Cu2O. Chemical and rheological characterization of the Cu2O–polysaccharide complex showed that the copper is covalently bound to the polysaccharide and that the complex exhibits higher viscosity and conductivity than the native polysaccharide. Examination of the complex’s inhibitory activity against the bacteria Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, and Bacillus subtilis and the fungus Candida albicans revealed a relatively high antimicrobial activity, especially against C. albicans (92% growth inhibition) as compared to the polysaccharide and to Cu2O alone. The antibiofilm activity was also found against P. aeruginosa PA14 and C. albicans biofilms. An atomic force microscopy examination of the surface morphology of the complex revealed needle-like structures (spikes), approximately 10 nm thick, protruding from the complex surface to a maximum height of 1000 nm, at a density of about 5000/μm2, which were not detected in the native polysaccharide. It seems that the spikes on the surface of the Cu2O–polysaccharide complex are responsible for the antimicrobial activities of the complex, that is, for disruption of microbial membrane permeability, leading to cell death. The study thus indicates that the superior qualities of the novel material formed by complexion of Cu2O to the polysaccharide should be studied further for various biotechnological applications.

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Section: Introductionmentioning

confidence: 99%

Red Microalgal Sulfated Polysaccharide–Cu₂O Complexes: Characterization and Bioactivity

Yehuda

Shalish

Kushmaro

et al. 2021

ACS Appl. Mater. Interfaces

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“…CuO nanoparticles synthesized using leaf extracts had shown good photocatalytic efficiency against methylene blue (MB) dye [45][46][47]. Moreover, Sreeju [48] had reported that the CuO-NPs are effective against bacteria killing.…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis of Flower-Shaped CuO Nanostructures and Their Photocatalytic and Antibacterial Activities

Siddiqui¹,

2020

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HIGHLIGHTS• Eugenol (4-allyl-2-methoxyphenol) extracted from O. sanctum leaves is used as a natural reducing agent for the synthesis of CuO nanoflowers (NFs).• CuO-NFs can degrade methylene blue with an efficiency of 90%. • CuO-NFs offer a new vision to deactivate multi-drug microorganisms. A B S T R AC T C o pper oxide nanoflowers (CuO-NFs) have been synthesized through a novel green route using Tulsi leaves-extracted eugenol (4-allyl-2-methoxyphenol) as reducing agent. Characterizations results reveal the growth of crystalline singlephase CuO-NFs with monoclinic structure. The prepared CuO-NFs can effectively degrade methylene blue with 90% efficiency. They also show strong barrier against E. coli (27 ± 2 mm) at the concentration of 100 µg mL −1 , while at the concentration of 25 µg mL −1 weak barrier has been found against all examined bacterial organisms. The results provide important evidence that CuO-NFs have sustainable performance in methylene blue degradation as well as bacterial organisms.

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“…The CNFST/Cu sample shows the best performance due to the presence of Cu NPs exhibiting unique antibacterial activity, as described in previous studies. 48,49 It is worth mentioning that the higher hypersensitivity of the Gram-positive bacteria toward the nanocomposites may be explained as a consequence of their less turgid cell membrane. 50…”

Section: Resultsmentioning

confidence: 99%

Enhanced photocatalytic and antimicrobial performance of a multifunctional Cu-loaded nanocomposite under UV light: theoretical and experimental study

et al. 2022

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In-vitro catalytic, antimicrobial and antioxidant activities of bioengineered copper quantum dots using Mangifera indica (L.) leaf extract

Cited by 46 publications

References 60 publications

Red Microalgal Sulfated Polysaccharide–Cu₂O Complexes: Characterization and Bioactivity

Red Microalgal Sulfated Polysaccharide–Cu₂O Complexes: Characterization and Bioactivity

Biosynthesis of Flower-Shaped CuO Nanostructures and Their Photocatalytic and Antibacterial Activities

Enhanced photocatalytic and antimicrobial performance of a multifunctional Cu-loaded nanocomposite under UV light: theoretical and experimental study

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In-vitro catalytic, antimicrobial and antioxidant activities of bioengineered copper quantum dots using Mangifera indica (L.) leaf extract

Cited by 46 publications

References 60 publications

Red Microalgal Sulfated Polysaccharide–Cu2O Complexes: Characterization and Bioactivity

Red Microalgal Sulfated Polysaccharide–Cu2O Complexes: Characterization and Bioactivity

Biosynthesis of Flower-Shaped CuO Nanostructures and Their Photocatalytic and Antibacterial Activities

Enhanced photocatalytic and antimicrobial performance of a multifunctional Cu-loaded nanocomposite under UV light: theoretical and experimental study

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Product

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Red Microalgal Sulfated Polysaccharide–Cu₂O Complexes: Characterization and Bioactivity

Red Microalgal Sulfated Polysaccharide–Cu₂O Complexes: Characterization and Bioactivity