In vitro bone regeneration and micro-mechanical strain in mechanoactive scaffolds

Nondestructive micro-computed tomography for biological imaging and quantification of scaffold–bone interaction in vivo

“…mCT-based computational models of scaffolds have not received much attention, yet. Nevertheless, in analogy to analyses performed on trabecular bone, the potential of mCT-based finite-element analyses has been shown to evaluate scaffold stiffness, and to determine the stresses and strains at the scaffold-cell interface [61][62][63][64]. Such computational analyses can be used as a screening tool to identify scaffolds that match desired properties [63].…”

“…Such computational analyses can be used as a screening tool to identify scaffolds that match desired properties [63]. Furthermore, the strains at the scaffold surface can be related to bone formation as measured with mCT [64], which has great potential to improve our understanding of the interaction between mechanical loading and bone regeneration and adaptation. More conceptual modeling of nutrient transport have been performed using mathematical modeling [65] and by using computational fluid dynamics (CFD) of idealized pore structures to calculate fluid-flow induced cell stresses [66].…”